Abstract：
:The urinary metabolites of n-nonane in male Fischer 344 rats, after administering the hydrocarbon by gavage, included gamma-valerolactone, delta-hexanolactone, 2,5-hexanedione, delta-heptanolactone, 1-heptanol, 2-nonanol, 3-nonanol, 4-nonanol, 4-nonanone and 5-methyl-2-(3-oxobutyl)furan. Metabolism strongly favored the formation of monoalcohols and lactones, which are the products of appropriately substituted hydroxy carboxylic acids. The metabolites were identified using gas chromatography (GC) and gas chromatography/mass spectrometry (GC/MS). High pressure liquid chromatography (HPLC) permitted the detection of the dicarboxylic acids malonic acid and glutaric acid in the n-nonane dosed rat urines.
journal_name
Chemospherejournal_title
Chemosphereauthors
Serve MP,Bombick DD,Baughman TM,Jarnot BM,Ketcha M,Mattie DRdoi
10.1016/0045-6535(95)00137-wsubject
Has Abstractpub_date
1995-07-01 00:00:00pages
2661-8issue
2eissn
0045-6535issn
1879-1298pii
004565359500137Wjournal_volume
31pub_type
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