Norepinephrine, enoximone, and nitric oxide for treatment of myocardial stunning and pulmonary hypertension in a newborn with diaphragmatic hernia.

Abstract:

:A newborn with right diaphragmatic hernia suffered myocardial stunning and suprasystemic pulmonary hypertension secondary to postpartal asphyxia. In addition to conventional therapy, norepinephrine, enoximone, and inhalational nitric oxide were successfully used. Norepinephrine improved myocardial perfusion pressure; the addition of enoximone, a phosphodiesterase-inhibitor, to beta-adrenergic agents increased cardiac performance. with decreasing concentrations of inhalational nitric oxide, severe pulmonary hypertension resolved after a few days, suggesting that transient endothelial dysfunction was partially responsible for pulmonary vasoconstriction in the newborn with congenital diaphragmatic hernia.

journal_name

J Pediatr Surg

authors

Schranz D,Huth R,Michel-Behnke I,Wippermann CF

doi

10.1016/0022-3468(95)90751-3

subject

Has Abstract

pub_date

1995-06-01 00:00:00

pages

801-4

issue

6

eissn

0022-3468

issn

1531-5037

pii

0022-3468(95)90751-3

journal_volume

30

pub_type

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