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Andrographolide prevents human breast cancer-induced osteoclastic bone loss via attenuated RANKL signaling.

Abstract：

:Bone metastasis is a common and serious complication in advanced cancers such as breast cancer, prostate cancer, and multiple myeloma. Agents that prevent bone loss could be used to develop an alternative therapy for bone metastasis. RANKL, a member of the tumor necrosis factor superfamily, has been shown to play a significant role in cancer-associated bone loss. In this study, we examined the efficacy of the natural compound andrographolide (AP), a diterpenoid lactone isolated from the traditional Chinese and Indian medicinal plant Andrographis paniculata, in reducing breast cancer-induced osteolysis. AP prevented human breast cancer-induced bone loss by suppressing RANKL-mediated and human breast cancer cell-induced osteoclast differentiation. Molecular analysis revealed that AP prevented osteoclast function by inhibiting RANKL-induced NF-κB and ERK signaling pathway in lower dose (20 μM), as well as inducing apoptosis at higher dose (40 μM). Thus, AP is a potent inhibitor of breast cancer-induced bone metastasis.

journal_name

Breast Cancer Res Treat

journal_title

Breast cancer research and treatment

authors

Zhai Z,Qu X,Yan W,Li H,Liu G,Liu X,Tang T,Qin A,Dai K

doi

10.1007/s10549-014-2844-7

subject

Has Abstract

pub_date

2014-02-01 00:00:00

pages

33-45

issue

1

eissn

0167-6806

issn

1573-7217

journal_volume

144

pub_type

杂志文章

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