The role of apoptosis in megakaryocytes and platelets.

abstract：:The prognostic significance of cytogenetic abnormalities was determined in 106 patients with well-characterized idiopathic myelofibrosis who were successfully karyotyped at diagnosis. 35% of the cases exhibited a clonal abnormality (37/106), whereas 65% (69/106) had a normal karyotype. Three characteristic defects, na...

journal_title：British journal of haematology

authors： Reilly JT,Snowden JA,Spearing RL,Fitzgerald PM,Jones N,Watmore A,Potter A

更新日期：1997-07-01 00:00:00

abstract：:Marginal zone lymphoma represents about 10% of all non-Hodgkin lymphomas (NHLs). 33% of patients with acquired angioedema (AAE) due to acquired C1-inhibitor (C1-INH) deficiency (C1-INH-AAE) have or will develop NHLs. C1-INH-AAE is a rare condition. We report the follow-up of 72 C1-INH-AAE patients, followed for a medi...

journal_title：British journal of haematology

authors： Castelli R,Wu MA,Arquati M,Zanichelli A,Suffritti C,Rossi D,Cicardi M

更新日期：2016-03-01 00:00:00

abstract：:While imatinib and other tyrosine kinase inhibitors (TKIs) are highly efficacious in the treatment of chronic myeloid leukaemia (CML), some patients become refractory to these therapies. After confirming that interleukin-3 receptor (IL3R, CD123) is highly expressed on CD34(+) /CD38(-) BCR-ABL1(+) CML stem cells, we in...

journal_title：British journal of haematology

authors： Frolova O,Benito J,Brooks C,Wang RY,Korchin B,Rowinsky EK,Cortes J,Kantarjian H,Andreeff M,Frankel AE,Konopleva M

更新日期：2014-09-01 00:00:00

abstract：:We present the rare occurrence of an inhibitor of factor VIII procoagulant arising in a patient with mild haemophilia A and rheumatoid arthritis. The inhibitor was transient and behaved like a low titre, type II factor VIII procoagulant inhibitor similar to previously reported cases (Biggs et al, 1972b). In vitro stud...

journal_title：British journal of haematology

authors： Bovill EG,Burns SL,Golden EA

更新日期：1985-10-01 00:00:00

abstract：:To investigate the role of neutrophils in complement-induced changes in vascular permeability, skin wheal and flare responses to intradermal injection of autologous activated serum complement were measured in normal and neutropenic subjects. In normal subjects, responses were dose-dependent and were abolished by remov...

journal_title：British journal of haematology

authors： Williamson LM,Sheppard K,Davies JM,Fletcher J

更新日期：1986-10-01 00:00:00

abstract：:Cold agglutinin syndrome (CAS) is usually associated with IgM cold agglutinins with titres exceeding 1000 at 4 degrees C and a thermal amplitude of 30-32 degrees C. Occasionally patients are encountered who although having clinical and laboratory findings compatible with CAS do not have the characteristic serological ...

journal_title：British journal of haematology

authors： Garratty G,Petz LD,Hoops JK

更新日期：1977-04-01 00:00:00

abstract：:A new method of in vivo bioassay for erythropoietin (EPO) is described. This method is based on the measurement of immature reticulocytes in EPO-treated mice using an automatic microcell counter, and is simpler and more precise than the existing methods of polycythaemic mouse assay and starved rat assay. Normal mice w...

journal_title：British journal of haematology

authors： Kawamura A,Imai N,Kawaguchi T,Hayakawa T

更新日期：1991-03-01 00:00:00

abstract：:Familial aggregation, linkage and case-control studies support the role of germline genes in the aetiology of lymphoid malignancies. To further examine the role of genetic variation underlying susceptibility, we analysed 1536 single nucleotide polymorphisms in 152 genes involved in apoptosis, DNA repair, immune respon...

journal_title：British journal of haematology

authors： Liang XS,Caporaso N,McMaster ML,Ng D,Landgren O,Yeager M,Chanock S,Goldin LR

更新日期：2009-08-01 00:00:00

abstract：:In four unrelated patients with chronic haemolysis and markedly reduced red blood cell (RBC) glutathione (49.5%, 12.6%, 11.5% and 15% of the normal concentration respectively), a severe glutathione synthetase (GSH-S, EC 6.3.2.3) deficiency was found. One case exhibited a neonatal haemolytic anaemia associated with oxo...

journal_title：British journal of haematology

authors： Corrons JL,Alvarez R,Pujades A,Zarza R,Oliva E,Lasheras G,Callis M,Ribes A,Gelbart T,Beutler E

更新日期：2001-02-01 00:00:00

abstract：:The existence of a phenomenon of rebound hypercoagulability after cessation of oral anticoagulant therapy is controversial. The sensitive procoagulant markers for in vivo thrombin and fibrin formation are potential tools for the reassessment of the presence of each a phenomenon. We examined 19 patients anticoagulated ...

journal_title：British journal of haematology

authors： Genewein U,Haeberli A,Straub PW,Beer JH

更新日期：1996-02-01 00:00:00

abstract：:Graft failure is a life-threatening complication after allogeneic haematopoietic stem cell transplantation (HSCT). We report a cohort of 19 consecutive patients (median age: 8·5 years) with acute leukaemias (n = 14) and non-malignant diseases (n = 5) who experienced graft failure after previous HSCT from matched (n = ...

journal_title：British journal of haematology

authors： Teltschik HM,Heinzelmann F,Gruhn B,Feuchtinger T,Schlegel P,Schumm M,Kremens B,Müller I,Ebinger M,Schwarze CP,Ottinger H,Zips D,Handgretinger R,Lang P

更新日期：2016-10-01 00:00:00

abstract：:Immunoglobulin kappa (Igkappa) gene recombinations can be used - similarly to IgH rearrangements - as clonal markers in B-lineage leukaemias. Based on the extensive junctional diversity, these rearrangements represent valuable targets for the analysis of minimal residual disease (MRD). In order to provide a simple met...

journal_title：British journal of haematology

authors： Stolz F,Panzer S,Panzer-Grümayer ER

更新日期：1999-08-01 00:00:00

abstract：:Changes in DNA copy number (CN) and DNA methylation represent important aberrations for lymphomas and other cancers. Here, for the first time, we show that the Illumina Infinium Methylation (IIM) assay, although not originally designed for CN profiling, is able to estimate CN changes. We compared the IIM CN profiles t...

journal_title：British journal of haematology

authors： Kwee I,Rinaldi A,Rancoita P,Rossi D,Capello D,Forconi F,Giuliani N,Piva R,Inghirami G,Gaidano G,Zucca E,Bertoni F

更新日期：2012-02-01 00:00:00

abstract：:During the 3 years 1984-86, 314 cases of multiple myeloma were diagnosed in the Health Care Region of Western Sweden. 180 of these cases were included in a clinical trial; 71 were notified to the trial but excluded; 49 cases were not reported to the trial; 14 were diagnosed post mortem. The crude incidence rate of mye...

journal_title：British journal of haematology

authors： Hjorth M,Holmberg E,Rödjer S,Westin J

更新日期：1992-01-01 00:00:00

abstract：:The in vitro efficacies of three new drugs--clofarabine (CLOF), nelarabine (NEL) and flavopiridol (FP) - were assessed in a panel of acute lymphoblastic leukaemia (ALL) cell lines. The 50% inhibitory concentration (IC50) for CLOF across all lines was 188-fold lower than that of NEL. B-lineage, but not T-lineage lines,...

journal_title：British journal of haematology

authors： Beesley AH,Palmer ML,Ford J,Weller RE,Cummings AJ,Freitas JR,Firth MJ,Perera KU,de Klerk NH,Kees UR

更新日期：2007-04-01 00:00:00

abstract：:Hodgkin's lymphoma (HL) can be cured in most of the patients, but in case of refractory disease or relapse after autologous stem cell transplantation (SCT) the prognosis becomes very poor. In these patients a consensus about the standard approach has not been achieved so far and only allogeneic SCT has shown a long-te...

journal_title：British journal of haematology

authors： Corradini P,Sarina B,Farina L

更新日期：2011-02-01 00:00:00

abstract：:Adult T cell leukaemia/lymphoma (ATL) is a human T cell leukaemia virus type-I (HTLV-I)-infected T cell malignancy with poor prognosis. We herein developed a novel therapeutic vaccine designed to augment an HTLV-I Tax-specific cytotoxic T lymphocyte (CTL) response that has been implicated in anti-ATL effects, and cond...

journal_title：British journal of haematology

authors： Suehiro Y,Hasegawa A,Iino T,Sasada A,Watanabe N,Matsuoka M,Takamori A,Tanosaki R,Utsunomiya A,Choi I,Fukuda T,Miura O,Takaishi S,Teshima T,Akashi K,Kannagi M,Uike N,Okamura J

更新日期：2015-05-01 00:00:00

abstract：:We studied the outcome of 24 peripheral blood stem cell (PBSC) graft recipients, who were T-cell depleted (TCD) with either 20 mg (n = 14) or 10 mg (n = 10) Campath-1H in vitro, in comparison with a retrospective cohort of 23 unmanipulated (UM) PBSC recipients. While the neutrophil engraftment was similar, the platele...

journal_title：British journal of haematology

authors： Chakrabarti S,MacDonald D,Hale G,Holder K,Turner V,Czarnecka H,Thompson J,Fegan C,Waldmann H,Milligan DW

更新日期：2003-04-01 00:00:00

abstract：:Two children affected by severe aplastic anaemia (SAA) underwent allogeneic bone marrow transplantation (BMT) using partially matched family donors. In both cases there was a successful engraftment of donor haemopoietic stem cells. However, after an initial erythropoietic recovery, 5 months following BMT both children...

journal_title：British journal of haematology

authors： Locatelli F,Pedrazzoli P,Barosi G,Zecca M,Porta F,Liberato L,Gambarana D,Nespoli L,Cazzola M

更新日期：1992-04-01 00:00:00

abstract：:Clinical and laboratory data are presented for two patients with a dyshaematopoietic disorder, and monosomy 7 in their bone marrow cells. The first patient, a 55-year-old woman, had been treated with chlorambucil for an ovarian carcinoma. After 4 years an oligoblastic myeloid leukaemia was diagnosed and she later died...

journal_title：British journal of haematology

authors： Boetius G,Hustinx TW,Smits AP,Scheres JM,Rutten FJ,Haanen C

更新日期：1977-09-01 00:00:00

abstract：:Our study aimed to determine the expression pattern and clinical relevance of CD99 in paediatric B-cell precursor acute lymphoblastic leukaemia (BCP-ALL). Our findings demonstrate that high expression levels of CD99 are mainly found in high-risk BCP-ALL, e.g. BCR-ABL1 and CRLF2Re/Hi, and that high CD99 mRNA levels are...

journal_title：British journal of haematology

authors： Chen D,Camponeschi A,Wu Q,Gerasimcik N,Li H,Shen X,Tan Y,Sjögren H,Nordlund J,Lönnerholm G,Abrahamsson J,Fogelstrand L,Mårtensson IL

更新日期：2019-02-01 00:00:00

abstract：:Until recently, primary central nervous system lymphoma (PCNSL) was associated with a uniformly dismal prognosis. It is now reasonable to anticipate long-term survival and possibly cure for a significant proportion of patients diagnosed with PCNSL. Accumulated data generated over the past 10 years has provided evidenc...

journal_title：British journal of haematology

authors： Wang CC,Carnevale J,Rubenstein JL

更新日期：2014-08-01 00:00:00

abstract：:The World Health Organization (WHO) lymphoma classification recognises anaplastic large cell lymphoma (ALCL), angioimmunoblastic lymphoma (AIL) and peripheral T-cell lymphoma, unspecified (PTCU) as nodal mature T-cell lymphomas. Little is known about long-term outcome and prognostic factors of these diseases. A retros...

journal_title：British journal of haematology

authors： Sonnen R,Schmidt WP,Müller-Hermelink HK,Schmitz N

更新日期：2005-05-01 00:00:00

abstract：:The presence of autoimmune diseases, including Systemic Sclerosis (SSc), suggest failure of the normal immune regulatory processes leading to activation and expansion of autoreactive effector immune cells. Recently, stem cell transplantation emerged as a novel rescue therapy for a variety of refractory autoimmune dise...

journal_title：British journal of haematology

authors： Cipriani P,Ruscitti P,Giacomelli R

更新日期：2015-02-01 00:00:00

abstract：:A primary analysis of the ASPIRE study found that the addition of carfilzomib to lenalidomide and dexamethasone (carfilzomib group) significantly improved progression-free survival (PFS) compared with lenalidomide and dexamethasone alone (control group) in patients with relapsed multiple myeloma (RMM). This post hoc a...

journal_title：British journal of haematology

authors： Dimopoulos MA,Stewart AK,Masszi T,Špička I,Oriol A,Hájek R,Rosiñol L,Siegel D,Mihaylov GG,Goranova-Marinova V,Rajnics P,Suvorov A,Niesvizky R,Jakubowiak A,San-Miguel J,Ludwig H,Palumbo A,Obreja M,Aggarwal S,Moreau P

更新日期：2017-05-01 00:00:00

abstract：:This study aimed to assess the potential of human cord blood (CB) cells to engraft in the xenogenic non-obese diabetic/severe combined immunodeficient (NOD/SCID) mouse model after in vitro expansion culture. We also studied the quality of human haemopoiesis arising from the transplantation of fresh or expanded cells i...

journal_title：British journal of haematology

authors： Denning-Kendall PA,Evely R,Singha S,Chapman M,Bradley BA,Hows JM

更新日期：2002-01-01 00:00:00

abstract：:Clinical and cytogenetic data were analysed in 54 patients with acute non-lymphocytic leukaemias (ANLL) or MDS (myelodysplastic syndromes) and deletion of the long arm of chromosome 7 (7q-), in order to determine if there is a commonly deleted region in 7q and to establish possible correlations between karyotypic feat...

journal_title：British journal of haematology

authors： Velloso ER,Michaux L,Ferrant A,Hernandez JM,Meeus P,Dierlamm J,Criel A,Louwagie A,Verhoef G,Boogaerts M,Michaux JL,Bosly A,Mecucci C,Van den Berghe H

更新日期：1996-03-01 00:00:00

abstract：:Clonal heterogeneity in multisited or recurrent lymphoid neoplasms is a phenomenon that has been increasingly studied in recent years. However, in mucosa-associated lymphoid tissue (MALT) lymphomas it remains largely unexplored. Patients diagnosed at our institution with multisited MALT lymphoma, from January 2009 to ...

journal_title：British journal of haematology

authors： Condom M,Climent F,Fernández D,Colomer D,Lopez-Guerra M,Varela M,Carro I,Maluquer C,Mercadal S,Oliveira AC,Pané M,Matias-Guiu X,González-Barca E,Sureda A,Domingo-Domenech E

更新日期：2020-05-23 00:00:00

abstract：:Pure fetal blood was obtained by direct-vision fetoscopy from 66 fetuses at 17-24 weeks gestation. The concentration of GSH and the activities of the enzymes gamma-glutamylcysteine synthetase (GCS), glutathione synthetase (GS), glutathione reductase (GR) and glutathione peroxidase (GPx) were analysed by established te...

journal_title：British journal of haematology

authors： Lestas AN,Rodeck CH

更新日期：1984-08-01 00:00:00

abstract：:Sideroblastic anaemia includes a heterogeneous group of rare conditions, characterized by decreased haem synthesis and mitochondrial iron overload, which are diagnosed by the presence of ringed sideroblasts in the bone marrow aspirate. The most frequent form is X-linked sideroblastic anaemia, caused by mutations of de...

journal_title：British journal of haematology

authors： Camaschella C

更新日期：2008-10-01 00:00:00