Malignant carcinoid tumors. An analysis of 103 patients with regard to tumor localization, hormone production, and survival.

Abstract:

:In a prospective study of 103 patients with carcinoid tumors consecutively referred for medical treatment, the most common sites of the primary tumors were the ileum (73%), bronchi (7%), and jejunum (4%). All patients had local metastases, and 96 (93%) also had liver metastases. The most common initial symptoms were diarrhea (32%), ileus (25%), and flush (23%). The overall frequency of diarrhea was 84% and of flush was 75%. Heart insufficiency caused by cardiac valve disease was seen in 33% of the patients. The carcinoid syndrome, including flush, diarrhea, and elevated urinary 5-hydroxyindole acetic acid (5-HIAA) concentrations, was manifested by 69 patients (67%), 64 of whom (93%) had carcinoid tumors of mid-gut origin. Elevated urinary 5-HIAA was found in 91 patients (88%), of which 89 displayed liver metastases. The plasma concentration of the tachykinin neuropeptide K (NPK) was elevated in 67 patients (66%), 63 of whom had tumors of the mid-gut region. Serum pancreatic polypeptide (PP) and human chorionic gonadotrophin alpha levels were elevated in 43% and 28% of the patients, respectively, and the highest levels were found in patients with metastatic bronchial carcinoid tumors. Thirty-nine of the 103 patients are now dead; 18 died of tumor progression, whereas 14 patients died of heart failure secondary to a carcinoid tricuspidal valve insufficiency. The estimated median survival from the time of histologic diagnosis was 14 years, and from the time of carcinoid syndrome was 8 years.

journal_name

Ann Surg

journal_title

Annals of surgery

authors

Norheim I,Oberg K,Theodorsson-Norheim E,Lindgren PG,Lundqvist G,Magnusson A,Wide L,Wilander E

doi

10.1097/00000658-198708000-00001

subject

Has Abstract

pub_date

1987-08-01 00:00:00

pages

115-25

issue

2

eissn

0003-4932

issn

1528-1140

journal_volume

206

pub_type

杂志文章
  • Laparoscopic liver resections: a feasibility study in 30 patients.

    abstract:OBJECTIVE:To assess the feasibility and safety of laparoscopic liver resections. SUMMARY BACKGROUND DATA:The use of the laparoscopic approach for liver resections has remained limited for technical reasons. Progress in laparoscopic procedures and the development of dedicated technology have made it possible to conside...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-200012000-00004

    authors: Cherqui D,Husson E,Hammoud R,Malassagne B,Stéphan F,Bensaid S,Rotman N,Fagniez PL

    更新日期:2000-12-01 00:00:00

  • Metabolic changes in patients severely affected by tetanus.

    abstract::Metabolic changes in six severely affected tetanus patients suffering from characteristic labile hypertension (maximum systolic blood pressure greater than 200 mmHG, maximum diurnal change in systolic pressure greater than 100 mmHg) were investigated. Daily urinary excretion of urea nitrogen increased gradually from t...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199101000-00011

    authors: Hiraide A,Katayama M,Sugimoto H,Yoshioka T,Sugimoto T

    更新日期:1991-01-01 00:00:00

  • Macrophage elimination increases bacterial translocation and gut-origin septicemia but attenuates symptoms and mortality rate in a model of systemic inflammation.

    abstract:OBJECTIVE:The central question tested in this study was whether dichloromethylene-diphosphonate (CL2MDP) liposome-mediated elimination of hepatic and splenic macrophages would influence zymosan-induced bacterial translocation and the zymosan-induced generalized inflammatory response. SUMMARY BACKGROUND DATA:Both an un...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199312000-00014

    authors: Nieuwenhuijzen GA,Haskel Y,Lu Q,Berg RD,van Rooijen N,Goris RJ,Deitch EA

    更新日期:1993-12-01 00:00:00

  • Prevalence, Management and Outcomes Related to Preoperative Medical Orders for life Sustaining Treatment (MOLST) in an Adult Surgical Population.

    abstract:OBJECTIVE:To determine prevalence of documented preoperative code status discussions and post-operative outcomes (specifically mortality, readmission and discharge disposition) of patients with completed Medical Orders for Life-Sustaining Treatments (MOLST) forms before surgery. SUMMARY OF BACKGROUND DATA:A MOLST form...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000004675

    authors: Tanious M,Lindvall C,Cooper Z,Tukan N,Peters S,Streid J,Fields K,Bader A

    更新日期:2020-12-18 00:00:00

  • The reservoir ileostomy: early experience with 54 patients.

    abstract::Reservoir and ileostomies were performed in 54 patients between 1972 and 1975. Primary colonic pathology included chronic ulcerative colitis in 47 patients, Crohn's colitis in one, familial polyposes in 5 and Gardner's Syndrome in one. Followup is complete and varies from 6 months to three years. All but three patient...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197702000-00008

    authors: Gelernt IM,Bauer JJ,Kreel I

    更新日期:1977-02-01 00:00:00

  • The influence of injury severity on complication rates after primary closure or colostomy for penetrating colon trauma.

    abstract::The management of penetrating colon injury has been frequently debated in the literature, yet few reports have evaluated primary closure versus diverting colostomy in similarly injured patients. Diverting colostomy is the standard of care when mucosal penetration is present, but primary closure in civilian practice ha...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198904000-00009

    authors: Nelken N,Lewis F

    更新日期:1989-04-01 00:00:00

  • Esophagogastrectomy for adenocarcinoma of the cardia. Ten years' experience and current approach.

    abstract::During a 10-year period, 94 surgical resections for adenocarcinoma of the cardia (75 "curative" and 19 palliative) were performed using three primary approaches: Group I (46 curative, 14 palliative), esophagogastrectomy performed through a left thoracotomy or left thoraco-abdominal incision; Group II (17 curative, 4 p...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198202000-00004

    authors: Molina JE,Lawton BR,Myers WO,Humphrey EW

    更新日期:1982-02-01 00:00:00

  • Management of combined pancreatoduodenal injuries.

    abstract::From 1969 to 1985, 129 patients with combined pancreatoduodenal injuries were treated at one urban trauma center. A total of 104 patients (80.6%) had penetrating wounds, and multiple visceral and vascular injuries were usually associated with the pancreatoduodenal injury. Primary repair or resection of one or both org...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198706000-00009

    authors: Feliciano DV,Martin TD,Cruse PA,Graham JM,Burch JM,Mattox KL,Bitondo CG,Jordan GL Jr

    更新日期:1987-06-01 00:00:00

  • A Clinical Nomogram for Predicting Node-positive Disease in Esophageal Cancer.

    abstract:OBJECTIVE:We developed and validated a nomogram predicting the likelihood of occult lymph node metastases in surgically resectable esophageal cancers. BACKGROUND:Patients with esophageal cancer with positive lymph nodes benefit from neoadjuvant therapy, but limitations in current clinical staging techniques mean nodal...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000003450

    authors: Semenkovich TR,Yan Y,Subramanian M,Meyers BF,Kozower BD,Nava R,Patterson GA,Kreisel D,Puri V

    更新日期:2019-07-03 00:00:00

  • Intestinal Oxygenation and Survival After Surgery for Necrotizing Enterocolitis: An Observational Cohort Study.

    abstract:OBJECTIVE:To assess whether regional intestinal oxygen saturation (rintSO2) and regional cerebral oxygen saturation (rcSO2) measurements aid in estimating survival of preterm infants after surgery for NEC. SUMMARY OF BACKGROUND DATA:Predicting survival after surgery for NEC is difficult yet of the utmost importance fo...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000003913

    authors: Kuik SJ,van der Heide M,Bruggink JLM,Bos AF,Verhagen AAE,Kooi EMW,Hulscher JBF

    更新日期:2020-04-20 00:00:00

  • Prospective Creation and Validation of the PREVENTT (Prediction and Enaction of Prevention Treatments Trigger) Scale for Surgical Site Infections (SSIs) in Patients With Diverticulitis.

    abstract:OBJECTIVE:Create and validate diverticulitis surgical site infection prediction scale. BACKGROUND:Surgical site infections cause significant morbidity after colorectal surgery. An infection prediction scale could target infection prevention bundles to high-risk patients. METHODS:Prospectively collected National Surgi...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000002859

    authors: Bordeianou L,Cauley CE,Patel R,Bleday R,Mahmood S,Kennedy K,Ahmed KF,Yokoe D,Hooper D,Rubin M,Partners Colorectal Collaborative.

    更新日期:2019-12-01 00:00:00

  • Cancer risk in extensive ulcerative colitis.

    abstract::Two hundred thirty-four patients with extensive ulcerative colitis from the city of Göteborg, Sweden have been followed up and the cumulative risk of development of cancer of the large bowel was estimated. These patients constitute all persons in this region who developed an extensive ulcerative colitis between 1951 a...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197812000-00018

    authors: Kewenter J,Ahlman H,Hultén L

    更新日期:1978-12-01 00:00:00

  • The international position on laparoscopic liver surgery: The Louisville Statement, 2008.

    abstract:OBJECTIVE:To summarize the current world position on laparoscopic liver surgery. SUMMARY BACKGROUND DATA:Multiple series have reported on the safety and efficacy of laparoscopic liver surgery. Small and medium sized procedures have become commonplace in many centers, while major laparoscopic liver resections have been...

    journal_title:Annals of surgery

    pub_type: 共识发展会议,杂志文章,实务指引

    doi:10.1097/sla.0b013e3181b3b2d8

    authors: Buell JF,Cherqui D,Geller DA,O'Rourke N,Iannitti D,Dagher I,Koffron AJ,Thomas M,Gayet B,Han HS,Wakabayashi G,Belli G,Kaneko H,Ker CG,Scatton O,Laurent A,Abdalla EK,Chaudhury P,Dutson E,Gamblin C,D'Angelica M,Nag

    更新日期:2009-11-01 00:00:00

  • How Much Weight Loss is Required for Cardiovascular Benefits? Insights From a Metabolic Surgery Matched-cohort Study.

    abstract:OBJECTIVE:The aim of this study was to determine the minimum amount of weight loss required to see a reduction in major adverse cardiovascular events (MACE). BACKGROUND:Although obesity is an established risk factor for morbidity and mortality, the minimum amount of weight loss to have a meaningful impact on cardiovas...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000004369

    authors: Aminian A,Zajichek A,Tu C,Wolski KE,Brethauer SA,Schauer PR,Kattan MW,Nissen SE

    更新日期:2020-10-01 00:00:00

  • Experimental comparison of the thrombogenicity of fibrin and PTFE flow surfaces.

    abstract::Two types of 4 mm ID prostheses were studied in the carotid arteries of the dog. These were noncrimped polypropylene-supported filamentous velour knitted Dacron (PPSFV) and expanded polytetrafluoroethylene (e-PTFE, Gore-Tex). Thrombus-"Free" Surface TFS) areas and patency rates were determined at the end of the implan...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198003000-00016

    authors: Kenny DA,Berger K,Walker MW,Robel SB,Boguslavsky L,Ray LI,Lischko MM,Sauvage LR

    更新日期:1980-03-01 00:00:00

  • Accuracy of physical examination, ultrasonography, and mammography in predicting residual pathologic tumor size in patients treated with neoadjuvant chemotherapy.

    abstract:OBJECTIVE:To assess the accuracy of physical examination, ultrasonography, and mammography in predicting residual size of breast tumors following neoadjuvant chemotherapy. BACKGROUND:Neoadjuvant chemotherapy is an accepted part of the management of stage II and III breast cancer. Accurate prediction of residual pathol...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/01.sla.0000197714.14318.6f

    authors: Chagpar AB,Middleton LP,Sahin AA,Dempsey P,Buzdar AU,Mirza AN,Ames FC,Babiera GV,Feig BW,Hunt KK,Kuerer HM,Meric-Bernstam F,Ross MI,Singletary SE

    更新日期:2006-02-01 00:00:00

  • En-Bloc Simultaneous Heart-Liver Transplantation in Adult Patients.

    abstract:INTRODUCTION:Complexity of combined heart-liver transplantation has resulted in low adoption rates. We report a case series of adult patients receiving en-bloc heart-liver transplantation (HLTx), describe technical aspects, and discuss benefits of the technique. METHODS:Retrospective review of patients receiving en-bl...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000003721

    authors: Brozzi NA,Loebe M,Souki FG,Beduschi T,Ghodzisad A,Tekin A,Nicolau-Raducu A,Vianna RM

    更新日期:2020-01-14 00:00:00

  • Endothelial-directed hepatic regeneration after partial hepatectomy.

    abstract:OBJECTIVE:To determine the role of the microvascular endothelium in the regulation of regenerating liver mass after partial hepatectomy. SUMMARY BACKGROUND DATA:Angiogenesis is critical for both pathologic and physiologic processes. The ability of certain tissues, such as the liver, kidney, and spleen, to regenerate a...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/01.SLA.0000059986.96051.EA

    authors: Greene AK,Wiener S,Puder M,Yoshida A,Shi B,Perez-Atayde AR,Efstathiou JA,Holmgren L,Adamis AP,Rupnick M,Folkman J,O'Reilly MS

    更新日期:2003-04-01 00:00:00

  • Prophylactic antibiotics in vascular surgery. Topical, systemic, or both?

    abstract::A prospective, randomized, blinded study was performed to determine whether prophylactic antibiotics would reduce the incidence of infection in peripheral vascular surgery and whether the route of antibiotic administration was important. Patients undergoing a vascular procedure with a groin incision were allocated to ...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000658-198009000-00011

    authors: Pitt HA,Postier RG,MacGowan AW,Frank LW,Surmak AJ,Sitzman JV,Bouchier-Hayes D

    更新日期:1980-09-01 00:00:00

  • A novel approach to high definition, high-contrast video capture in abdominal surgery.

    abstract:OBJECTIVE:The aim of this study was to define the best available option for video capture of surgical procedures for educational and archival purposes, with a view to identifying methods of capturing high-quality footage and identifying common pitfalls. SUMMARY BACKGROUND DATA:Several options exist for those who wish ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/01.sla.0000250441.69758.cd

    authors: Cosman PH,Shearer CJ,Hugh TJ,Biankin AV,Merrett ND

    更新日期:2007-04-01 00:00:00

  • Operative treatment of Crohn's ileocolitis complicated by ileosigmoid and ileovesical fistulae.

    abstract::Ileovesical and ileosigmoid fistulae were found to coexist in 22 patients with Crohn's ileocolitis. Persistent or recurrent urinary tract infection was a complaint in all cases, and 11 patients reported pneumaturia and/or fecaluria. Thus, bladder involvement was either suspected or clinically apparent in each patient....

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198801000-00010

    authors: Schraut WH,Chapman C,Abraham VS

    更新日期:1988-01-01 00:00:00

  • Variation and Impact of Multiple Complications on Failure to Rescue After Inpatient Surgery.

    abstract:OBJECTIVE:To examine the extent to which multiple, sequential complications impacts variation in institutional postoperative mortality rates. BACKGROUND:Failure to rescue (FTR) has been proposed as an underlying factor in hospital variation in surgical mortality. However, little is currently known about hospital varia...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000001917

    authors: Massarweh NN,Anaya DA,Kougias P,Bakaeen FG,Awad SS,Berger DH

    更新日期:2017-07-01 00:00:00

  • Marfan's syndrome. Broad spectral surgical treatment cardiovascular manifestations.

    abstract::Most patients with Marfan's syndrome have cardiovascular manifestations and complications of these abnormalities lead to death in 50% of patients by the age of 32. This report is concerned with the performance of 79 operations to control these problems in 41 patients during a 16-year period. There were 3 early deaths ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198310000-00009

    authors: Crawford ES

    更新日期:1983-10-01 00:00:00

  • "Contemplating the Next Maneuver": Functional Neuroimaging Reveals Intraoperative Decision-making Strategies.

    abstract:OBJECTIVE:To investigate differences in the quality, confidence, and consistency of intraoperative surgical decision making (DM) and using functional neuroimaging expose decision systems that operators use. SUMMARY BACKGROUND DATA:Novices are hypothesized to use conscious analysis (effortful DM) leading to activation ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000001651

    authors: Leff DR,Yongue G,Vlaev I,Orihuela-Espina F,James D,Taylor MJ,Athanasiou T,Dolan R,Yang GZ,Darzi A

    更新日期:2017-02-01 00:00:00

  • Management of Pneumoperitoneum: Role and Limits of Nonoperative Treatment.

    abstract:OBJECTIVES:The aim of this study was to compare morbidity and mortality between nonoperative and operative treatment of pneumoperitoneum. BACKGROUND:Pneumoperitoneum is a potentially life-threatening condition that has been traditionally treated with surgical intervention. Adequately powered studies comparing treatmen...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000003492

    authors: Udelsman B,Lee K,Qadan M,Lillemoe KD,Chang D,Lindvall C,Cooper Z

    更新日期:2019-07-23 00:00:00

  • Acute Kidney Injury in Burn Patients: Clinically Significant Over the Initial Hospitalization and 1 Year After Injury: An Original Retrospective Cohort Study.

    abstract:OBJECTIVE:To examine the development of acute kidney injury (AKI) after burn injury as an independent risk factor for increased morbidity and mortality over initial hospitalization and 1-year follow-up. BACKGROUND:Variability in fluid resuscitation and difficulty recognizing early sepsis are major barriers to preventi...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000001979

    authors: Thalji SZ,Kothari AN,Kuo PC,Mosier MJ

    更新日期:2017-08-01 00:00:00

  • Thoracic duct in patients with multiple organ failure: no major route of bacterial translocation.

    abstract:OBJECTIVE:To determine whether translocation of bacteria or endotoxin occurred into the thoracic duct in patients with multiple organ failure (MOF). SUMMARY BACKGROUND DATA:Translocation of bacteria or endotoxin has been proposed as a causative factor for MOF in patients without an infectious focus, although it has ra...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199901000-00017

    authors: Lemaire LC,van Lanschot JB,Stoutenbeek CP,van Deventer SJ,Dankert J,Oosting H,Gouma DJ

    更新日期:1999-01-01 00:00:00

  • Therapeutic delay and survival after surgery for cancer of the pancreatic head with or without preoperative biliary drainage.

    abstract:OBJECTIVE:To evaluate the relation between delay in surgery because of preoperative biliary drainage (PBD) and survival in patients scheduled for surgery for pancreatic head cancer. BACKGROUND:Patients with obstructive jaundice due to pancreatic head cancer can undergo PBD. The associated delay of surgery can lead to ...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1097/SLA.0b013e3181fd36a2

    authors: Eshuis WJ,van der Gaag NA,Rauws EA,van Eijck CH,Bruno MJ,Kuipers EJ,Coene PP,Kubben FJ,Gerritsen JJ,Greve JW,Gerhards MF,de Hingh IH,Klinkenbijl JH,Nio CY,de Castro SM,Busch OR,van Gulik TM,Bossuyt PM,Gouma DJ

    更新日期:2010-11-01 00:00:00

  • Distal splenorenal shunt (DSS) in children: analysis of the first 21 consecutive cases.

    abstract::Twenty-one children from the ages of 4 to 12 years old were treated for esophageal hemorrhage by distal splenorenal shunt (DSS). In four patients, thrombosis of the shunt occurred within the first 24 hours after operation. In the other 17 children, long-term shunt patency was verified. Only one thrombosis has occurred...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198204000-00004

    authors: Maksoud JG,Mies S

    更新日期:1982-04-01 00:00:00

  • Transplantation of pediatric donor kidneys to adult recipients. Is there a critical donor age?

    abstract::Cadaver kidneys remain a scarce resource, yet single pediatric donor kidneys are underutilized at some centers. Between 1967 and 1984, 133 single pediatric and 318 adult donor cadaver transplants were performed. Patient and graft survival, renal function, and complications in adult recipients grouped by donor age were...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198608000-00011

    authors: Wengerter K,Matas AJ,Tellis VA,Quinn T,Soberman R,Veith FJ

    更新日期:1986-08-01 00:00:00