Effect of intracisternal phentolamine on cerebral blood flow after subarachnoid injection of blood.

Abstract:

:The hydrogen clearance method was used to measure total and focal cerebral blood flow (CBF) in the monkey before and for 5 hours after a simulated subarachnoid hemorrhage (SAH). Some monkeys also received 0.2 to 1.0 mg/kg phentolamine intracisternally 3 hours after SAH. Results show that SAH did not change cerebrovascular resistance, but as cerebral perfusion pressure decreased, CBF fell transiently. Phentolamine injected intracisternally 3 hours after SAH produced a significant fall in arterial blood pressure; cerebrovascular resistance did not change but CBF decreased significantly. These data indicate that intracisternal phentolamine cannot be considered potentially useful to treat ischemic encephalopathy after SAH.

journal_name

J Neurosurg

journal_title

Journal of neurosurgery

authors

Martins AN,Newby N,Doyle TF,Kobrine AI,Ramirez A

doi

10.3171/jns.1976.44.3.0353

subject

Has Abstract

pub_date

1976-03-01 00:00:00

pages

353-8

issue

3

eissn

0022-3085

issn

1933-0693

journal_volume

44

pub_type

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