Bladder muscle contractility. Comparative effects and mechanisms of action of atropine, propantheline, flavoxate, and imipramine.

Abstract:

:The anticholinergic and antispasmodic activity of atropine, propantheline, imipramine, and flavoxate were judged by each drug's ability to inhibit bethanechol chloride and barium chloride-induced canine detrusor contractions. In this in vitro model, atropine and propantheline are pure anticholinergic agents. Imipramine significantly decreases both bethanechol and barium-induced contractions, while flavoxate only minimally inhibits the response to either stimulant.

journal_name

Urology

journal_title

Urology

authors

Benson GS,Sarshik SA,Raezer DM,Wein AJ

doi

10.1016/0090-4295(77)90279-5

subject

Has Abstract

pub_date

1977-01-01 00:00:00

pages

31-5

issue

1

eissn

0090-4295

issn

1527-9995

journal_volume

9

pub_type

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