Abstract:
:Intracranial hypertension following traumatic brain injury is associated with considerable morbidity and mortality. Hemorrhagic hypovolemia commonly coexists with head injury in this population of patients. Therapy directed at correcting hypovolemic shock includes vigorous volume expansion with crystalloid solutions. It is hypothesized that, following traumatic brain injury, cerebrovascular dysfunction results in rapid loss of brain compliance, resulting in increased sensitivity to cerebrovascular venous pressure. Increased central venous pressure (CVP) occurring with vigorous crystalloid resuscitation may therefore contribute to the loss of brain compliance and the development of intracranial hypertension. The authors tested this hypothesis in miniature swine subjected to traumatic brain injury, hemorrhage, and resuscitation. Elevated CVP following resuscitation from hemorrhage to a high CVP significantly worsened intracranial hypertension in animals with concurrent traumatic brain injury, as compared to animals subjected to traumatic brain injury alone (mean +/- standard error of the mean: 33.0 +/- 2.0 vs. 20.0 +/- 2.0 mm Hg, p < 0.05) or to animals subjected to the combination of traumatic brain injury, hemorrhage, and resuscitation to a low CVP (33.0 +/- 2.0 vs. 24.0 +/- 2.0 mm Hg, p < 0.05). These data support the hypothesis that reduction in brain compliance can occur secondary to elevation of CVP following resuscitation from hemorrhagic shock. This may worsen intracranial hypertension in patients with traumatic brain injury and hemorrhagic shock.
journal_name
J Neurosurgjournal_title
Journal of neurosurgeryauthors
Hariri RJ,Firlick AD,Shepard SR,Cohen DS,Barie PS,Emery JM 3rd,Ghajar JBdoi
10.3171/jns.1993.79.3.0421subject
Has Abstractpub_date
1993-09-01 00:00:00pages
421-7issue
3eissn
0022-3085issn
1933-0693journal_volume
79pub_type
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pub_type: 杂志文章
doi:10.3171/2017.5.JNS162897
更新日期:2018-09-01 00:00:00
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abstract:OBJECT:The aim of this study was to compare designed scaffolds with a random-pored sponge scaffold to determine what role scaffold architecture plays in a cortical injury model. METHODS:Cylindrical scaffolds (3x3 mm) were made of a poly-(epsilon-caprolactone) polymer with 2 different molds from a 3D printer and had ei...
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pub_type: 杂志文章
doi:10.3171/JNS/2008/109/10/0715
更新日期:2008-10-01 00:00:00
abstract::Melanocytomas are rare tumors of the central nervous system that are believed to arise from leptomeningeal melanocytes. A young girl presented with a contrast-enhancing cystic mass in the temporal horn of the left lateral ventricle. Microsurgical resection of a black-colored vascular tumor supplied by the anterior cho...
journal_title:Journal of neurosurgery
pub_type: 杂志文章
doi:10.3171/JNS/2008/109/9/0480
更新日期:2008-09-01 00:00:00
abstract::In order to elucidate some of the signal transduction processes in human meningioma cells, the authors studied the effect of epidermal growth factor (EGF) and bromocriptine on inositol phospholipid hydrolysis, using low-passage human meningioma cells in culture. Epidermal growth factor is a well-studied mitogenic fact...
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pub_type: 杂志文章
doi:10.3171/jns.1994.80.5.0890
更新日期:1994-05-01 00:00:00
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pub_type: 评论,信件
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更新日期:2001-11-01 00:00:00
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pub_type: 杂志文章
doi:10.3171/JNS/2008/108/4/0791
更新日期:2008-04-01 00:00:00
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pub_type: 杂志文章
doi:10.3171/jns.1980.52.1.0047
更新日期:1980-01-01 00:00:00
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pub_type: 杂志文章
doi:10.3171/jns.1975.42.6.0728
更新日期:1975-06-01 00:00:00
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pub_type: 杂志文章
doi:10.3171/jns.1995.82.2.0291
更新日期:1995-02-01 00:00:00
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pub_type: 杂志文章
doi:10.3171/jns.2002.97.supplement
更新日期:2002-12-01 00:00:00
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journal_title:Journal of neurosurgery
pub_type: 杂志文章
doi:10.3171/jns.1979.51.4.0556
更新日期:1979-10-01 00:00:00
abstract:OBJECT:Mild traumatic brain injury (mTBI), as defined by Glasgow Coma Scale (GCS) score of 13 or higher, is a common problem in the United States and worldwide, estimated to affect more than 1 million patients yearly. When associated with intracranial hemorrhage, it is a common reason for neurosurgical consultation and...
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pub_type: 杂志文章
doi:10.3171/2014.10.JNS132713
更新日期:2015-09-01 00:00:00
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doi:10.3171/jns.2006.105.1.51
更新日期:2006-07-01 00:00:00
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pub_type: 杂志文章
doi:10.3171/JNS/2008/108/2/0330
更新日期:2008-02-01 00:00:00
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journal_title:Journal of neurosurgery
pub_type: 杂志文章
doi:10.3171/jns.1983.58.6.0932
更新日期:1983-06-01 00:00:00
abstract::Two cases of traumatic epidural hematomas are presented. Both patients were minimally symptomatic, and neither required surgical intervention. It is suggested that the use of computerized tomography in head trauma will reveal a new class of epidural hematoma patients who may be treated conservatively. ...
journal_title:Journal of neurosurgery
pub_type: 杂志文章
doi:10.3171/jns.1981.54.2.0248
更新日期:1981-02-01 00:00:00
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pub_type: 杂志文章
doi:10.3171/jns.2003.98.4.0837
更新日期:2003-04-01 00:00:00
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pub_type: 杂志文章
doi:10.3171/jns.1986.64.1.0151
更新日期:1986-01-01 00:00:00
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pub_type: 杂志文章
doi:10.3171/jns.1988.68.2.0241
更新日期:1988-02-01 00:00:00
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doi:10.3171/spi.1999.90.1.0138
更新日期:1999-01-01 00:00:00
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更新日期:2010-12-01 00:00:00
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pub_type: 杂志文章
doi:10.3171/jns.1986.65.1.0074
更新日期:1986-07-01 00:00:00
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journal_title:Journal of neurosurgery
pub_type: 杂志文章
doi:10.3171/jns.1979.50.3.0374
更新日期:1979-03-01 00:00:00
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更新日期:2006-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:1999-07-01 00:00:00
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journal_title:Journal of neurosurgery
pub_type: 杂志文章
doi:10.3171/jns.1979.50.2.0246
更新日期:1979-02-01 00:00:00