Abstract:
PURPOSE:The stability of lipid emulsions (LE) containing various cosurfactants (oleic acid, cholesterol, Tween 80, or HCO-60) was evaluated using the maximum total interaction energy, Vtmax and the energy barrier for coalescence, W. METHODS:The Vtmax and W were calculated from the zeta potential and the rate of increase in LE particle size, respectively. RESULTS:The Vtmax and W of LE containing the oleic acid were 0.598 x 10(-19) J and 3.03 x 10(-19) J, respectively, while those of LE without the cosurfactant were 0.141 x 10(-19) J and 1.36 x 10(-19) J. CONCLUSIONS:These findings suggest that oleic acid prevents the flocculation and coalescence of LE. The Vtmax and W of LE containing the cholesterol were 0.435 x 10(-19) J and 0.63 x 10(-19) J, respectively, suggesting that the cholesterol prevents the flocculation of LE but does not affect the coalescence. Analysis of the stability of LE was performed by the separate considerations of the flocculation and coalescence.
journal_name
Pharm Resjournal_title
Pharmaceutical researchauthors
Yamaguchi T,Nishizaki K,Itai S,Hayashi H,Ohshima Hdoi
10.1023/a:1016205203264subject
Has Abstractpub_date
1995-09-01 00:00:00pages
1273-8issue
9eissn
0724-8741issn
1573-904Xjournal_volume
12pub_type
杂志文章abstract:PURPOSE:The aim of the study was to investigate whether dopamine is transferred along the olfactory pathway to the brain following nasal administration to mice. METHODS:[3H]-Dopamine was administered nasally or intravenously to female mice. Brain tissue samples were excised and the radioactive content was measured. Th...
journal_title:Pharmaceutical research
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journal_title:Pharmaceutical research
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journal_title:Pharmaceutical research
pub_type: 杂志文章
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journal_title:Pharmaceutical research
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更新日期:1993-08-01 00:00:00
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更新日期:1989-03-01 00:00:00