Abstract:
:The alteration in glomerular basement membrane permeability associated with microangiopathy in streptozotocin-induced diabetic rats was studied by determining the movement across the glomerular basement membrane of anionic ferritin probes injected into rats at different points in the development of the disease. Visualization of the concentration gradient of anionic ferritin and changes in ultrastructure was accomplished by electron microscopic examination of renal tissue prepared from both control and diabetic rats. In all control rats, the anionic ferritin did not leave the glomerular capillary lumen, nor were there any changes in the normal morphology of the glomerular capillary wall. In the diabetic animals, the concentration of anionic ferritin shifted from the capillary lumen in the abluminal direction. Distinct morphologic changes, such as widening of endothelial intercellular junctions, focal detachment of podocyte foot processes, and extensive thickening of the glomerular basement membrane, were noted in the diabetic rat, and these changes appear to correlate with the observed increase in permselectivity of anionic ferritin across the glomerular capillary wall.
journal_name
J Am Podiatr Med Assocjournal_title
Journal of the American Podiatric Medical Associationauthors
Boyd RB,Thompson VW,Atkin Jdoi
10.7547/87507315-86-2-57subject
Has Abstractpub_date
1996-02-01 00:00:00pages
57-62issue
2eissn
8750-7315issn
1930-8264journal_volume
86pub_type
杂志文章abstract::A range of patient-oriented and practitioner-oriented outcomes were used to evaluate the efficacy of "gait plate" shoe inlays in controlling symptoms associated with in-toeing in otherwise healthy children. For 18 in-toeing children, parents completed a preintervention questionnaire. Then, during randomized trials, fo...
journal_title:Journal of the American Podiatric Medical Association
pub_type: 临床试验,杂志文章
doi:10.7547/87507315-90-2-70
更新日期:2000-02-01 00:00:00
abstract::Synovial sarcoma of the extremities represents 7% of all soft-tissue sarcomas. This article presents the case of a patient who was treated for a synovial sarcoma of the lateral aspect of the distal lower leg extending to the ankle and involving the fibular bone. The patient underwent a wide excision of the tumor, incl...
journal_title:Journal of the American Podiatric Medical Association
pub_type: 杂志文章
doi:10.7547/87507315-92-2-90
更新日期:2002-02-01 00:00:00
abstract::This case report was presented because there are few published cases of a solitary lesion of primary osteoma cutis occurring in the foot. It is an unusual cause of heel pain. ...
journal_title:Journal of the American Podiatric Medical Association
pub_type: 信件
doi:10.7547/87507315-85-6-341
更新日期:1995-06-01 00:00:00
abstract:BACKGROUND:In the presence of a large gap where end-to-end repair of the torn Achilles tendon is difficult and V-Y advancement would likely be insufficient, augmentation is sometimes required. At our institute we have used primarily the hamstring autograft augmentation technique for the past two decades. The aim of thi...
journal_title:Journal of the American Podiatric Medical Association
pub_type: 杂志文章
doi:10.7547/18-014
更新日期:2020-03-01 00:00:00
abstract:BACKGROUND:Despite the importance to patients of driving, no well-established guideline exists to help either the patient or the physician determine when it is safe for the patient to return to driving. Previous studies have recommended 6 weeks postoperatively before patients can return to driving safely. Several scien...
journal_title:Journal of the American Podiatric Medical Association
pub_type: 杂志文章
doi:10.7547/17-025
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Stenotrophomonas maltophilia is an uncommon gram-negative bacterium often found in individuals with long-standing broad-spectrum antibiotic use or catheter use; individuals undergoing hemodialysis; and individuals with prolonged respiratory disease, specifically, cystic fibrosis. To our knowledge, there are ...
journal_title:Journal of the American Podiatric Medical Association
pub_type: 杂志文章
doi:10.7547/18-193
更新日期:2020-09-01 00:00:00
abstract::From 1982 to 1991, 17 patients underwent a lower extremity arterial bypass to salvage an ischemic transmetatarsal amputation at the New England Deaconess Hospital. Eleven patients were male, and 16 had diabetes for an average of 29 years. The mean age was 71 years. Twelve patients presented with an ischemic ulcer, one...
journal_title:Journal of the American Podiatric Medical Association
pub_type: 杂志文章
doi:10.7547/87507315-83-2-87
更新日期:1993-02-01 00:00:00
abstract::The flexor digitorum accessorius longus muscle was encountered during routine dissection of the posteromedial region of the left ankle of an 84-year-old female cadaver, by a first year podiatric medical student, in a lower extremity anatomy laboratory session. The purpose of this article is to describe the flexor digi...
journal_title:Journal of the American Podiatric Medical Association
pub_type: 杂志文章,评审
doi:10.7547/87507315-86-11-559
更新日期:1996-11-01 00:00:00
abstract::Tendinopathy in the presence of gouty arthropathy is relatively common, yet the clinical suspicion for gout involvement in acute tendon pain remains low. A 49-year-old man presented with an acute, tender, erythematous mass to the right posterior heel. A computed tomographic scan was obtained, which revealed a septated...
journal_title:Journal of the American Podiatric Medical Association
pub_type: 杂志文章
doi:10.7547/18-129
更新日期:2019-07-01 00:00:00
abstract::Behcet's disease is a rare autoimmune systemic vasculitis. It usually presents with a symptom complex involving primarily mucocutaneous lesions, genital lesions, and uveitis. When it involves the lower extremity, venous and arterial disease predominates, and joint involvement occurs in approximately 50% of patients. W...
journal_title:Journal of the American Podiatric Medical Association
pub_type: 杂志文章
doi:10.7547/16-087
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND:Understanding the concept of kinematic coupling is essential when selecting the appropriate therapeutic strategy and grasping mechanisms for the occurrence of injuries. A previous study reported that kinematic coupling between the rearfoot and shank during running and walking were different. However, because...
journal_title:Journal of the American Podiatric Medical Association
pub_type: 杂志文章
doi:10.7547/16-024
更新日期:2018-01-01 00:00:00
abstract::A single case of a tibial sesamoid fracture in a softball player is reported here. A review of the literature confirms that this is an unusual and difficult problem to treat in the athletic population given the significant loads placed on the sesamoids during athletic activity. In the case presented, conservative care...
journal_title:Journal of the American Podiatric Medical Association
pub_type: 杂志文章
doi:10.7547/0970085
更新日期:2007-01-01 00:00:00
abstract::Primary lymphoma of bone (PLB) is an uncommon entity and is extremely rare in the foot and ankle. In this case, PLB was identified from the bone specimen after a bunionectomy of the first and fifth metatarsals. The diagnosis was confirmed with pathologic analysis, genetic karyotyping, positron emission and computed to...
journal_title:Journal of the American Podiatric Medical Association
pub_type: 杂志文章,评审
doi:10.7547/0003-0538-104.3.291
更新日期:2014-05-01 00:00:00
abstract::The author explains the need to document medical records to provide protection in litigation and to enhance medical care. Practical tips to make documentation easier and more efficient are given. ...
journal_title:Journal of the American Podiatric Medical Association
pub_type: 杂志文章
doi:10.7547/87507315-85-3-135
更新日期:1995-03-01 00:00:00
abstract::Poorly fitting footwear has frequently been cited as an etiologic factor in the pathway to diabetic foot ulceration. However, we are unaware of any reports in the medical literature specifically measuring shoe size versus foot size in this high-risk population. We assessed the prevalence of poorly fitting footwear in ...
journal_title:Journal of the American Podiatric Medical Association
pub_type: 杂志文章
doi:10.7547/0960290
更新日期:2006-07-01 00:00:00
abstract::Flatfoot may be classified as pathologic or physiologic. Pathologic flatfoot is often characterized by stiffness of the foot, causes disability, and requires treatment. Physiologic flatfoot is a normal variation; it causes no disability and tends to improve with time. Physiologic flatfoot is most common in individuals...
journal_title:Journal of the American Podiatric Medical Association
pub_type: 历史文章,杂志文章,评审
doi:10.7547/87507315-89-2-94
更新日期:1999-02-01 00:00:00
abstract::This study hypothesized that individuals who have a history of knee pain during repetitive weightbearing activities have a higher subtalar joint inclination angle than those with a history of foot pain. Study participants were selected on the basis of results of a written questionnaire that asked about the site and ca...
journal_title:Journal of the American Podiatric Medical Association
pub_type: 杂志文章
doi:10.7547/87507315-93-6-481
更新日期:2003-11-01 00:00:00
abstract:BACKGROUND:we sought to determine the frequency of toenail onychomycosis in diabetic patients, to identify the causative agents, and to evaluate the epidemiologic risk factors. METHODS:data regarding patients' diabetic characteristics were recorded by the attending internal medicine clinician. Clinical examinations of...
journal_title:Journal of the American Podiatric Medical Association
pub_type: 杂志文章
doi:10.7547/1010049
更新日期:2011-01-01 00:00:00
abstract::Using data from a multicenter nationwide multispecialty survey, the authors investigated the efficacy of in-office dermatophyte test medium (DTM) and central laboratory cultures used to confirm onychomycosis across samples collected by podiatric, dermatologic, and primary-care physicians. The samples collected by podi...
journal_title:Journal of the American Podiatric Medical Association
pub_type: 杂志文章,多中心研究
doi:10.7547/87507315-93-3-195
更新日期:2003-05-01 00:00:00
abstract::Given the age-related decline in foot strength and flexibility, and the emerging evidence that foot problems increase the risk of falls, established guidelines for falls prevention recommend that older adults have their feet examined by a podiatrist as a precautionary measure. However, these guidelines do not specify ...
journal_title:Journal of the American Podiatric Medical Association
pub_type: 杂志文章,评审
doi:10.7547/1030452
更新日期:2013-11-01 00:00:00
abstract::This study compared preoperative and postoperative results for selected radiographic measurements of 30 patients undergoing the modified Austin bunionectomy procedure for the correction of hallux abducto valgus. Significant reductions in all postoperative radiographic values were demonstrated, including hallux abductu...
journal_title:Journal of the American Podiatric Medical Association
pub_type: 杂志文章
doi:10.7547/87507315-88-6-290
更新日期:1998-06-01 00:00:00
abstract::Multiple surgical procedures have been described for the correction of hallux limitus deformity. We describe a new modification of the Youngswick procedure for the surgical treatment of hallux limitus. Other procedures for hallux limitus correction are also discussed. This modified Youngswick procedure will provide a ...
journal_title:Journal of the American Podiatric Medical Association
pub_type: 杂志文章
doi:10.7547/0970420
更新日期:2007-09-01 00:00:00
abstract:BACKGROUND:Human amniotic membrane is used to prevent peritendinous adhesions after tendon injuries. This study compares the mechanical properties of modified Kessler repairs and modified Kessler repairs strengthened using multiple layers of human amniotic membrane. METHODS:Twenty flexor digitorum profundus tendons of...
journal_title:Journal of the American Podiatric Medical Association
pub_type: 杂志文章
doi:10.7547/15-036
更新日期:2016-09-02 00:00:00
abstract::Diabetes often causes ulcers on the feet of diabetic patients. A 56-year-old, insulin-dependent, diabetic woman presented to the wound care center with a Wagner grade 3 ulcer of the right heel. She reported a 3-week history of ulceration with moderate drainage and odor and had a history of ulceration and osteomyelitis...
journal_title:Journal of the American Podiatric Medical Association
pub_type: 杂志文章
doi:10.7547/14-091
更新日期:2016-03-01 00:00:00
abstract::Accidental falls in the older population are common and often result in serious injury. Although a number of factors have been recognized as risk factors for falling, the effect of footwear on postural stability is often overlooked. This article reviews the literature on the effect of various footwear features on post...
journal_title:Journal of the American Podiatric Medical Association
pub_type: 杂志文章,评审
doi:10.7547/87507315-89-7-346
更新日期:1999-07-01 00:00:00
abstract:BACKGROUND:Older people have multiple foot health problems; therefore, nursing staff need to pay attention to the foot care of older people, especially in long-term care and nursing homes. The aim of this study was to investigate the knowledge of nursing staff (n = 16) regarding foot care, their foot-care activities, a...
journal_title:Journal of the American Podiatric Medical Association
pub_type: 杂志文章
doi:10.7547/1010159
更新日期:2011-03-01 00:00:00
abstract:BACKGROUND:There is a lack of data that could address the effects of off-the-shelf insoles on gait variables in healthy people. METHODS:Thirty-three healthy volunteers ranging in age from 18 to 35 years were included to this study. Kinematic and kinetic data were obtained in barefoot, shoe-only, steel insole, silicone...
journal_title:Journal of the American Podiatric Medical Association
pub_type: 杂志文章
doi:10.7547/16-175
更新日期:2018-09-01 00:00:00
abstract::Articular hyaline cartilage is of interest to both the clinician and the basic scientist because of its unique physical and chemical properties which are a consequence of its biochemical composition. Although it is a tissue which is hypocellular, avascular, and also lacks nerves and lymphatics, it is active in synthes...
journal_title:Journal of the American Podiatric Medical Association
pub_type: 杂志文章
doi:10.7547/87507315-85-5-277
更新日期:1995-05-01 00:00:00
abstract::Osteomyelitis and osteoarthropathy may appear clinically and radiographically similar. Many retrospective and some prospective studies have shown that magnetic resonance imaging provides valuable information about the pathologic basis of disease, specifically in the differentiation of osteomyelitis from osteoarthropat...
journal_title:Journal of the American Podiatric Medical Association
pub_type: 杂志文章,评审
doi:10.7547/87507315-86-4-164
更新日期:1996-04-01 00:00:00
abstract:BACKGROUND:In this study, we aimed to evaluate the potential use of a 3-phase bone scintigraphy method to determine the level of amputation on treatment cost, morbidity and mortality, reamputation rates, and the duration of hospitalization in diabetic foot. METHODS:Thirty patients who were admitted to our clinic betwe...
journal_title:Journal of the American Podiatric Medical Association
pub_type: 杂志文章
doi:10.7547/0003-0538-104.3.227
更新日期:2014-05-01 00:00:00