Abstract：
:Clinically, bisphosphonate-related osteonecrosis (BRON) only occurs in the jaw (BRONJ). We aimed to determine differences between the jaw and other bones, as well as the relationship between periodontal pathogens and BRON. Twelve male Wistar rats were divided into two groups: group Z (n=6) were subcutaneously injected with zoledronic acid weekly for 4 weeks; group C (n=6) were injected with saline. One week after the final injection, rats in both groups were divided into three subgroups: Aa subgroup was injected with freeze-dried Aggregatibacter actinomycetemcomitans into bone marrow of the mandibles and femurs, while CFA and saline subgroups were injected with complete Freund's adjuvant (CFA) or saline using the same protocol. Four weeks after those injections, the rats were euthanized. Areas of osteonecrosis were measured histologically. Statistically, rats in group Z showed significantly wider osteonecrosis areas in both mandibles and femurs with each type of local injection than rats in group C. In group Z, mandibles and femurs stimulated with A. actinomycetemcomitans or CFA had significantly wider osteonecrosis areas than those stimulated with saline. We have developed a rat model with BRONJ-like lesions. Our results showed BRON to develop not only in the jaw but also in other types of bone following an inflammatory stimulus.
journal_name
Int J Oral Maxillofac Surgjournal_title
International journal of oral and maxillofacial surgeryauthors
Tsurushima H,Kokuryo S,Sakaguchi O,Tanaka J,Tominaga Kdoi
10.1016/j.ijom.2013.06.011subject
Has Abstractpub_date
2013-11-01 00:00:00pages
1481-7issue
11eissn
0901-5027issn
1399-0020pii
S0901-5027(13)00289-0journal_volume
42pub_type
杂志文章abstract：:Internal jugular vein thrombosis is rare. It is often secondary to prolonged central venous cannulation and associated with local or distant malignancy. The authors present a case of intra-operative thrombosis of the internal jugular vein which complicated subsequent microvascular anastomosis of a radial forearm free ...
journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章
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abstract：:This systematic review and exploratory meta-analysis of the available evidence was performed to examine whether early nerve repair of lingual nerve (LN) and inferior alveolar nerve (IAN) injuries has an effect on neurosensory recovery. A literature search was conducted to identify relevant studies meeting the inclusio...
journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章,评审
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abstract：:The aim of this study was to compare the effect of intramuscular (IM) injection and consumption of 8 mg dexamethasone in patients after lower third molar (LTM) surgery. 20 healthy Thai patients, average age 20 years, with bilateral LTM removal were recruited for this study, a double blinded, paired sample clinical tri...
journal_title：International journal of oral and maxillofacial surgery
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journal_title：International journal of oral and maxillofacial surgery
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abstract：:Bone quality is defined by structural and material characteristics. Most studies on the mandible have focused on the analysis of structural characteristics, with insufficient investigation of material characteristics. This study tested whether zoledronate affects the material characteristics of newly formed mandibular...
journal_title：International journal of oral and maxillofacial surgery
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doi：10.1016/j.ijom.2018.02.002
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journal_title：International journal of oral and maxillofacial surgery
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abstract：:The purpose of this study was to evaluate abnormal magnetic resonance imaging (MRI) findings related to temporomandibular joint (TMJ) pain. This study included 245 joints of 152 patients with temporomandibular disorders with anterior disc displacement; of these, 129 joints had joint pain whereas 116 joints had no join...
journal_title：International journal of oral and maxillofacial surgery
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journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章
doi：10.1054/ijom.2000.0023
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journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章
doi：10.1016/j.ijom.2013.03.021
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journal_title：International journal of oral and maxillofacial surgery
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更新日期：1994-12-01 00:00:00
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journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章
doi：10.1016/j.ijom.2012.01.012
更新日期：2012-07-01 00:00:00
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journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章
doi：10.1016/s0901-5027(87)80152-2
更新日期：1987-06-01 00:00:00
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journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章
doi：10.1016/j.ijom.2014.05.013
更新日期：2014-10-01 00:00:00
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journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章,评审
doi：10.1016/j.ijom.2016.05.005
更新日期：2016-10-01 00:00:00
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journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章
doi：10.1016/j.ijom.2006.01.022
更新日期：2006-06-01 00:00:00
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journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章,评审
doi：10.1016/s0901-5027(05)80601-0
更新日期：1994-04-01 00:00:00
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journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章
doi：10.1016/s0901-5027(05)80731-3
更新日期：1992-10-01 00:00:00
abstract：:Three-phase bone scintigraphy was undertaken to check the anastomotic patency and monitor the viability of vascularized bone grafts. Ten consecutive patients who underwent vascularized bone grafting of the mandible were reviewed. A successful clinical outcome was achieved in 8 patients. The graft failed in 2 patients....
journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章
doi：
更新日期：2000-08-01 00:00:00
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journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章
doi：10.1016/s0901-5027(88)80156-5
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journal_title：International journal of oral and maxillofacial surgery
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journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章
doi：10.1016/s0901-5027(87)80131-5
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journal_title：International journal of oral and maxillofacial surgery
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journal_title：International journal of oral and maxillofacial surgery
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journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章
doi：10.1016/j.ijom.2004.10.022
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abstract：:Arthroscopic procedures for diagnosis and treatment of temporomandibular joint (TMJ) diseases are widely used. Few adverse effects of the procedures have been reported. In this in vivo study, diagnostic arthroscopy was performed in the left TMJ of seven castrated male goats, the right TMJ serving as a control. The goa...
journal_title：International journal of oral and maxillofacial surgery
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doi：10.1016/s0901-5027(05)80326-1
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abstract：:Teratomas are tumors that are derived from two or three of the primordial germ layers: ectoderm, mesoderm and endoderm. They arise most commonly in a midline or paraxial location from the brain to the sacral area and are most often located in the sacrococcygeal region. Head and neck teratomas are rare neoplasms and th...
journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章,评审
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更新日期：2009-12-01 00:00:00
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journal_title：International journal of oral and maxillofacial surgery
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journal_title：International journal of oral and maxillofacial surgery
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更新日期：2016-12-01 00:00:00
abstract：:A case involving the rare occurrence of a maxillary giant cell tumour in association with Paget's disease is reported. Surgical treatment consisted of a combined intraoral and temporal approach for tumour resection with temporalis muscle flap reconstruction of the maxilla. The postoperative course was complicated by a...
journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章
doi：10.1016/s0901-5027(05)80292-9
更新日期：1994-06-01 00:00:00
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journal_title：International journal of oral and maxillofacial surgery
pub_type： 杂志文章
doi：10.1054/ijom.2002.0228
更新日期：2002-12-01 00:00:00
