Abstract:
:Marketing authorization application dossiers of 17 orphan drugs (ODs) and 51 non-ODs evaluated by the European Medicines Agency (EMA) in the period 2009-2010 were compared. We aimed to identify whether any differences existed between ODs and non-ODs in number and type of deficits brought forward during the EMA review, regarding the clinical development plan, clinical outcome and medical need and studied whether these deficits were similarly associated with marketing approval in the EU. In 71% of the ODs dossiers and 65% of the non-ODs dossiers marketing approval was granted. Differences in deficits were found, but similarities in the way ODs and non-ODs were reviewed and marketing approval decisions were taken, underline that regulatory standards are equally high.
journal_name
Drug Discov Todayjournal_title
Drug discovery todayauthors
Putzeist M,Mantel-Teeuwisse AK,Llinares J,Gispen-De Wied CC,Hoes AW,Leufkens HGdoi
10.1016/j.drudis.2013.06.012subject
Has Abstractpub_date
2013-10-01 00:00:00pages
1001-6issue
19-20eissn
1359-6446issn
1878-5832pii
S1359-6446(13)00198-0journal_volume
18pub_type
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journal_title:Drug discovery today
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journal_title:Drug discovery today
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