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Long-term symptom patterns in duodenal ulcer: psychosocial factors.

Abstract：

:Seventy-five patients with recent-onset dyspepsia and endoscopically visible duodenal ulcer underwent psychological evaluation. Following ranitidine treatment, they were reinterviewed periodically for 12 to 76 months (mean 38.6). Ulcer symptoms were present during a mean of 14.9% of follow-up months. Patients did significantly worse if they had a low-status occupation, low education, depression, stressful life events, or abnormal Minnesota Multiphasic Personality Inventory at baseline. Of patients recalling premorbid life stress, those with a normal MMPI had a particularly benign course, whereas those with an abnormal MMPI did particularly poorly (6% versus 29% of months symptomatic: p < 0.04). Age, gender, smoking, drinking, antiinflammatory drugs, pepsinogen, Helicobacter pylori titers, and initial healing had no prognostic effect. Low socioeconomic status, life stress, depression, and psychopathology each predict a relatively poor symptom outcome for duodenal ulcer treated with antisecretory therapy, but psychologically stable individuals who develop an ulcer under stress have an excellent long-term prognosis.

journal_name

J Psychosom Res

journal_title

Journal of psychosomatic research

authors

Levenstein S,Prantera C,Varvo V,Arca M,Scribano ML,Spinella S,Berto E

doi

10.1016/s0022-3999(96)00196-1

subject

Has Abstract

pub_date

1996-11-01 00:00:00

pages

465-72

issue

5

eissn

0022-3999

issn

1879-1360

pii

S0022399996001961

journal_volume

41

pub_type

杂志文章

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