Abstract：
:To investigate the biochemical mechanism responsible for NO-induced neurotoxicity, the effect of sodium nitroprusside(SNP), a NO-generating agent, on PC12 cells was studied. The cell density was dose-dependently inhibited by SNP. Neuronally differentiated PC12 cells showed a higher resistance to SNP than the undifferentiated cells. The inhibitory effect was enhanced by 8-Br-cGMP, and reduced by methylene blue. However, 8-Br-cGMP alone had no significant cytotoxicity. SNP also inhibited [3H]-thymidine incorporation into the cells in a dose-dependent manner. The dose response curves for reducing cell density and for inhibiting thymidine incorporation, were found to be virtually superimposable. These results suggested that cytotoxicity elicited by NO seemed to be due to inhibition of DNA synthesis in PC12 cells.
journal_name
Chemospherejournal_title
Chemosphereauthors
Nakamura Y,Yasuda M,Fujimori H,Kiyono M,Pan-Hou Hdoi
10.1016/s0045-6535(96)00379-7subject
Has Abstractpub_date
1997-02-01 00:00:00pages
317-24issue
2eissn
0045-6535issn
1879-1298pii
S0045653596003797journal_volume
34pub_type
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