Abstract:
:Tetrabromobisphenol A (TBBPA) can cause diverse adverse effects including neurotoxicity. Emerging TBBPA derivatives, with high structure similarity to the parent compound, are now being concerned. In this study, the potential neurotoxicities of four TBBPA derivatives and their parent compound were studied by cell viability inhibition in rat pheochromocytoma cells (PC12) and the corresponding molecular mechanisms were investigated. The cellular toxicity was correlated with the chemical hydrophobicity. Tetrabromobisphenol A bis(2-hydroxyethyl ether) (TBBPA-BHEE) exhibited the highest cellular toxicity to PC12 due to its lowest hydrophobicity among these 5 tested compounds. Further experiments showed that TBBPA-BHEE disturbed dopamine (DA) secretion and altered acetylcholinesterase (AChE) enzymatic activity in PC12 cells. The molecular mechanism study indicated that TBBPA-BHEE induced cellular toxicity to PC12 cells through ROS-mediated caspase activation to a large extent, which was partially attenuated by the anti-oxidation of Vitamin E. Moreover, in contrast to TBBPA, the occurrence of TBBPA-BHEE toxicity to PC12 was not attributed to activation of mitogen-activated protein kinases (MAPKs) or thyroid hormone (TH) signaling pathway. These findings suggest TBBPA derivatives, especially TBBPA-BHEE, as potential neurotoxins need urgent attention.
journal_name
Chemospherejournal_title
Chemosphereauthors
Liu Q,Ren X,Long Y,Hu L,Qu G,Zhou Q,Jiang Gdoi
10.1016/j.chemosphere.2016.03.117subject
Has Abstractpub_date
2016-07-01 00:00:00pages
194-203eissn
0045-6535issn
1879-1298pii
S0045-6535(16)30441-6journal_volume
154pub_type
杂志文章相关文献
CHEMOSPHERE文献大全abstract::Predicting the reversible interactions between aromatic amines and soil is essential for assessing the mobility, bioavailability and exposure from contaminated sites. Reversible sorption mechanisms of aniline and alpha-naphthylamine were investigated by using single and binary solute sorption to five soils at several ...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/s0045-6535(00)00511-7
更新日期:2001-08-01 00:00:00
abstract::A fine porcelain open-cell photo-catalytic filter with titanium dioxide (TiO(2)) was evaluated for sterilization and sanitation of bio-polluted industrial water. In simulated seawater industrial effluent samples, the populations of Escherichia coli and Vibrio parahaemolyticus quickly decreased and reached non-detectab...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2005.03.061
更新日期:2006-01-01 00:00:00
abstract::Low concentrations of arsenic (As) contamination in aquatic environment is a worldwide issue, which is of great concern. To evaluate the impact of low concentrations of As on zebrafish, we measured the growth, antioxidant enzymes including superoxide dismutase (SOD) and catalase (CAT), oxidative damage (malondialdehyd...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2018.08.010
更新日期:2018-11-01 00:00:00
abstract::Dehalogenation is one of the most important reactions in environmental pollution control, for instance, the degradation of persistent organic pollutants (POPs). Recently, fluoroacetate dehalogenase (FAcD) has been reported to catalyze the dehalogenation reactions, which shows great potential in treating halogenated po...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2020.126803
更新日期:2020-09-01 00:00:00
abstract::The study was carried out from spring 1999 to spring 2001 to monitor the residue levels of organophosphorus pollutants (OPP) in aquatic environment of the drainage canal surrounding a pesticide factory at Damietta Governorate. Water, sediment, and fish samples were collected at six different seasonal periods. OPPs wer...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2005.09.019
更新日期:2006-06-01 00:00:00
abstract::Atmospheric emissions of neonicotinoid seed treatment insecticides as particulate matter in field crops occur mainly for two reasons: 1) due to abraded dust of treated seed generated during planting using vacuum planters, and 2) as a result of disturbances (tillage or wind events) in the surface of parental soils whic...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2017.08.126
更新日期:2017-12-01 00:00:00
abstract::Acid mine drainage (AMD) is one of an important pollution sources associated with mining activities and often inhibits plant growth. Plant growth promoting bacteria has received extensive attention for enhancing adaptability of plants growing in AMD polluted soils. The present study investigated the effect of plant gr...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2020.128345
更新日期:2021-01-01 00:00:00
abstract::The purpose of this study was to determine the feed to milk transfer of 17 PCDD/Fs and 18 PCBs in goats exposed to a 10-week long-term intake of contaminated hay collected in the vicinity of a hazardous municipal waste incinerator. The sum of PCDD/Fs and PCBs WHO-I-TEQ was found to be higher than 3 ng kg(-1) of milk f...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2005.10.052
更新日期:2006-07-01 00:00:00
abstract::This paper describes the use of photo-fenton process for color removal from textile wastewater stream. The wastewater sample to be treated was simulated by using colorless polyvinyl alcohol (PVA) and reactive dyestuff of R94H. As a result, the hydroxyl radical (HO*) oxidation can effectively remove color, but the chem...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/s0045-6535(99)00524-x
更新日期:2000-10-01 00:00:00
abstract::Color removal from biologically pre-treated molasses wastewater by means of chemical oxidation with ozone has been investigated. Batch experiments have been performed in order to analyze the influence of ozone dosage and reaction time on color removal, molecular weight distribution and decolorization kinetics. Dependi...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/S0045-6535(03)00159-0
更新日期:2003-06-01 00:00:00
abstract::In a preliminary study, the uptake and the mobility of uranium (U) by black oak trees (Quercus velutina) were assessed by measuring the isotopic composition of tree rings in two mature oak trees in a heavy metal contaminated bog in Concord, MA. The bog is adjacent to a nuclear industrial facility that has been process...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/s0045-6535(00)00376-3
更新日期:2001-08-01 00:00:00
abstract::This study evaluates the reliability of serum measurements of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and toxicity equivalence (TEQ) in individuals with no prior exposure to TCDD or dioxin-like compounds above background levels. Reliability was measured over three time-periods in the same individuals. TCDD and TEQ ...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/s0045-6535(99)00357-4
更新日期:2000-05-01 00:00:00
abstract::Tris (1-chloro-2-propyl) phosphate (TCIPP) and tris (2-chloroethyl)phosphate (TCEP) are two widely used chlorinated organophosphate flame retardants (ClOPFRs), and have been frequently detected in various environmental media. Concern is now growing whether TCIPP and TCEP can cause neurotoxicity since they have similar...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2018.12.198
更新日期:2019-04-01 00:00:00
abstract::PCDD/F analyses were made in soil and ambient air samples taken from Kocaeli, an industrialized area of Turkey. Results showed that the levels of PCDD/F pollution are comparable to the levels observed in the various urban areas in the world. PCDD/F concentrations in surface soils ranged between 0.4 and 4.27 pg I-TEQ k...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2004.12.029
更新日期:2005-06-01 00:00:00
abstract::Laboratory experiments were conducted to determine environmental variables that affect the affinities and persistence of the nerve agent O-ethyl S-(2-diisopropylaminoethyl) methylphosphonothiolate (VX) at dilute concentrations in environmental matrices. Quantitative analyses of VX and its degradation products were per...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2004.08.041
更新日期:2004-12-01 00:00:00
abstract::Polymer-driven flocculation and dewatering of mature fine tailings (MFT) is critical to improve their consolidation. MFT flocculation and dewatering depends on the size of the suspended clay particles, and on the composition and properties of the liquid in which they are dispersed. The effect of water chemistry on the...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2018.05.171
更新日期:2018-10-01 00:00:00
abstract::This study compared the performance of an anaerobic fluidized bed membrane bioreactor (AFMBR)-zeolite adsorption-reverse osmosis (RO) system and an anoxic-aerobic MBR-RO system for municipal wastewater reclamation. Both MBR-RO systems were operated in parallel with the same operating conditions. The results showed tha...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2019.125569
更新日期:2020-04-01 00:00:00
abstract::The fertilized eggs of Japanese medaka (Oryzias latipes) were exposed to estrone (E1) at 5-5000 ng L(-1) for 15 d, and the hatched fry were exposed continuously to the same concentrations for the additional 15 d. Adverse effects on hatchability, time to hatching, and gross abnormalities occurred at 50 ng L(-1) or abov...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2013.06.025
更新日期:2013-10-01 00:00:00
abstract::Dioxins and dioxin-like (DL) compounds are some of the most toxic chemicals being highly persistent in the environment. The toxicological effects of dioxins are mediated via the aryl hydrocarbon receptor (AhR). Compounds of diverse structure and lipophility can bind and activate AhR. The AhR transactivation bioassay i...
journal_title:Chemosphere
pub_type: 杂志文章,评审
doi:10.1016/j.chemosphere.2012.06.055
更新日期:2012-11-01 00:00:00
abstract::Perfluorooctanoic acid (PFOA) is a dispersive persistent organic pollutant in the environment. Accumulating reports suggest that PFOA is toxic to human lymphocytes; however, the toxicological effects of PFOA on these cells remain largely unclear. In this study, ultra-performance liquid chromatography (UPLC)-based meta...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2019.124810
更新日期:2020-01-01 00:00:00
abstract::Three prepackaged solid phase extraction (SPE) cartridges: two modified styrene divinylbenzene, Bond Elut ENV and Bond Elut PPL (Varian), and one N-vinylpyrrolidone (Strata-X, Phenomenex), were assessed for isolation of THM precursors from three surface waters in Manitoba, Canada. The dissolved organic matter (DOM) fr...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2016.10.118
更新日期:2017-02-01 00:00:00
abstract::The dissipation of carbendazim and chloramphenicol alone and in combination and their effects on soil fungal:bacterial ratios and soil enzyme activities were investigated. The results revealed that carbendazim dissipation was little affected by chloramphenicol, whereas chloramphenicol dissipation was found to be retar...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2011.03.038
更新日期:2011-07-01 00:00:00
abstract::During the last years the pulsed electric field (PEF) method entered several fields of application. A promising application is the decontamination of hospital wastewater effluents, which are loaded with pathogenic and increasingly with antibiotic-resistant bacteria. For this study, Pseudomonas putida suspended in buff...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2008.11.066
更新日期:2009-04-01 00:00:00
abstract::This study investigates the effect of sodium nitroprussiate (SNP), an exogenous NO-donor, on the joint toxicity of binary mixtures of cetyltrimethylammonium chloride (CTAC) and fluoranthene (Flu) (CTAC/Flu), which are representatives for surfactants and polycyclic aromatic hydrocarbons (PAHs) respectively, in a unicel...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2013.07.012
更新日期:2014-02-01 00:00:00
abstract::Ballast water managements systems (BWMS) installed on vessels may use active substances to inactivate organisms. This paper provides new insights in the global issue of noxious disinfection by-products (DBP) discharge with ballast water, and the related risk assessment for human health. The GESAMP ballast water workin...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2019.06.101
更新日期:2019-11-01 00:00:00
abstract::Planarian neoblasts are somatic stem cells that have the potential to be used in genotoxicity assays due to their proliferative nature, sensitivity to genotoxic agents, and experimental accessibility. Two freshwater planarian species, Girardia tigrina and Girardia schubarti, were used to develop a neoblast-based micro...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2008.04.058
更新日期:2008-07-01 00:00:00
abstract::The number, morphology and elemental composition of nanoparticles (<100 nm) in marine water was investigated using Variable Pressure Scanning Electron Microscopy (VP-SEM) and Energy-dispersive X-ray spectroscopy (EDS). Preliminary research conducted in the Baltic Sea showed that the number of nanoparticles in seawater...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2018.05.022
更新日期:2018-09-01 00:00:00
abstract::Polychorodibenzo-p-dioxin and polychlorodibenzofuran (PCDD/F) and polychlorobiphenyl (PCB) concentrations were analyzed in fat samples of seven people from a village where the population had been exposed to chlorophenols for over twenty years, and in seven matched controls. There was only a minor difference in both PC...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/0045-6535(95)00036-8
更新日期:1995-04-01 00:00:00
abstract::Pesticide mixtures are common in the streams of agricultural or urban catchments. Individual and cartel toxicity of four different pesticides, namely Endosulfan, Carbofuran, Methyl parathion and Cypermethrin were studied. Sub acute exposure (1/10th of LC50) for 1, 7, 15, 30 and 60 days in Clarias batrachus active tiss...
journal_title:Chemosphere
pub_type: 杂志文章,评审
doi:10.1016/j.chemosphere.2015.09.065
更新日期:2016-02-01 00:00:00
abstract::Passive samplers are used to measure dissolved nonionic organic contaminants (NOCs) in environmental media. More recently, reverse polyethylene samplers (RePES) have been used with spiked sediments to recreate interstitial water exposure concentrations and observed toxicity. In the present study, RePES were used with ...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2010.12.076
更新日期:2011-04-01 00:00:00