Abstract：
PURPOSE:To evaluate the efficacy of using forward second harmonic generation (SHG) and 2-dimensional fast Fourier-transform (2D-FFT) analysis for the label-free characterization and quantification of morphologic changes in the corneal stroma after collagen crosslinking (CXL). SETTING:Department of Physics, National Taiwan University, Taipei, Taiwan. DESIGN:Experimental study. METHODS:En face forward SHG imaging and 2D-FFT analysis were performed on ex vivo porcine corneas at the depths of 100, 200, 400, and 800 μm. Morphologic changes in stromal collagen fiber in control, ultraviolet-A (UVA), riboflavin, and riboflavin-UVA treated porcine corneas were assessed. Hematoxylin-eosin staining and Sirius red staining were performed for comparison. RESULTS:Corneas after CXL treatment tended to have collagen fibers that were wavy compared with the linear pattern in normal corneas. Quantitative 2D-FFT analysis of forward SHG images also showed an increase in the standard deviations of the distribution of stromal collagen fiber orientations, which is indicative of the changed pattern of crosslinked stromal collagen fibers. CONCLUSIONS:Second harmonic generation imaging showed the morphologic changes in stromal collagen after CXL treatment. The linear collagen fibers in normal corneal stroma became wavy after treatment. With the introduction of 2D-FFT analysis, the morphologic changes can be quantified.
journal_name
J Cataract Refract Surgjournal_title
Journal of cataract and refractive surgeryauthors
Tan HY,Chang YL,Lo W,Hsueh CM,Chen WL,Ghazaryan AA,Hu PS,Young TH,Chen SJ,Dong CYdoi
10.1016/j.jcrs.2012.11.036subject
Has Abstractpub_date
2013-05-01 00:00:00pages
779-88issue
5eissn
0886-3350issn
1873-4502pii
S0886-3350(13)00065-5journal_volume
39pub_type
杂志文章abstract：PURPOSE:To report a case series of post-phacoemulsification endophthalmitis despite antibiotic prophylaxis with an intracameral injection of a licensed cefuroxime formulation (Aprokam). SETTING:University Hospitals of Pointe-à-Pitre, Guadeloupe, and Fort-de-France, Martinique, French West Indies. DESIGN:Retrospective...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2016.06.030
更新日期：2016-09-01 00:00:00
abstract：PURPOSE:Iris intraocular implants were developed to manage congenital or traumatic iris defects. However, they are also used to change the color of patient eyes. The aim of this retrospective series was to report complications in patients managed in France after cosmetic implantation. SETTING:Ophthalmological institut...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1097/j.jcrs.0000000000000032
更新日期：2020-01-01 00:00:00
abstract：PURPOSE:To determine whether frozen cultured sheets of human allogeneic epidermal keratinocytes (CEAK) improved wound repair after experimental corneal ablation by photorefractive keratectomy (PRK). SETTING:Hospital "Luis Sanchez Bulnes" de la Asociación para Evitar la Ceguera en Mexico, I.A.P, and Department of Cell ...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/s0886-3350(01)01349-9
更新日期：2002-09-01 00:00:00
abstract：PURPOSE:To report the clinical outcomes of implantation of a new Ferrara intrastromal corneal ring segment (ICRS) with a 210-degree arc length in eyes with keratoconus. SETTING:Private eye clinic, Belo Horizonte, Brazil METHODS:Statistical analysis included preoperative and postoperative uncorrected distance visual a...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2009.04.035
更新日期：2009-09-01 00:00:00
abstract：PURPOSE:To report clinical and confocal microscopy characteristics of haze-like opacities in corneas after laser in situ keratomileusis (LASIK). SETTING:Department of Ophthalmology, Johann Wolfgang Goethe-University, Frankfurt am Main, Germany. METHODS:Eighteen eyes of 11 patients with clinically apparent corneal clo...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/s0886-3350(02)02050-3
更新日期：2003-09-01 00:00:00
abstract：:Capsular bag distension syndrome (CBDS) is a rare complication of cataract surgery due to collection of fluid behind the intraocular lens (IOL). Nd:Yag laser capsulotomy is commonly performed to release the fluid collection; however, the potential risk of infection and inflammation has led to adaptation of numerous su...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1097/j.jcrs.0000000000000362
更新日期：2020-12-01 00:00:00
abstract：PURPOSE:To determine the predictability and consistency of corneal flap thickness, flap diameter, and hinge length with the modern 100 microm head of the Moria LSK-One manual microkeratome. SETTING:Private clinic, office-based practice. METHODS:Forty-two consecutive eyes with no previous surgery having thin flap lase...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2004.10.056
更新日期：2005-06-01 00:00:00
abstract：PURPOSE:To assess visual acuity tolerance to defocus caused by residual refractive errors after clear lens extraction (CLE) with apodized diffractive intraocular lens (IOL) implantation. SETTING:Fernández-Vega Ophthalmological Institute, Oviedo, Spain. METHODS:In this prospective study, 150 eyes of 75 consecutive pat...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2007.10.020
更新日期：2008-02-01 00:00:00
abstract：:The iris-claw intraocular lens (IOL) was recently approved by the U.S. Food and Drug Administration for the correction of refractive disorders. Previous reports are not uniform regarding its potential to induce inflammatory reaction. We report the case of a young healthy patient who experienced persistent and intolera...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2006.02.079
更新日期：2006-08-01 00:00:00
abstract：PURPOSE:To report the prevalence of ocular surface dysfunction in patients presenting for cataract surgery evaluation. SETTING:Duke University Eye Center and Weill Cornell Ophthalmology, single-physician practices. DESIGN:Prospective case series. METHODS:Consecutive patients presenting for cataract surgery evaluatio...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2018.06.026
更新日期：2018-09-01 00:00:00
abstract：PURPOSE:To find the incidence, contributing factors, outcomes, and clinical impact of intraoperative posterior capsule striae. SETTING:Iladevi Cataract & IOL Research Centre, Ahmedabad, India. METHODS:In a prospective study, 100 consecutive eyes had phacoemulsification and intraocular lens (IOL) (AcrySof MA30BA) impl...
journal_title：Journal of cataract and refractive surgery
pub_type： 临床试验,杂志文章
doi：10.1016/s0886-3350(99)00197-2
更新日期：1999-11-01 00:00:00
abstract：:Cataract surgery can be safely performed in patients with Stevens-Johnson syndrome (SJS) with visually significant cataracts. Maintaining ocular surface integrity improves the prognosis of cataract surgery in this high-risk population. We present the outcome of cataract surgery in a retrospective chart review of 3 eye...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2004.07.023
更新日期：2005-04-01 00:00:00
abstract：PURPOSE:To evaluate changes in anterior chamber depth (ACD) and intraocular pressure (IOP) after phacoemulsification in eyes with occludable angles and compare the results with those in eyes with normal open angles. SETTING:Eye Clinic, Ipoh General Hospital, Ipoh, Perak, Malaysia. METHODS:Patients with nonglaucomatou...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2010.02.024
更新日期：2010-08-01 00:00:00
abstract：PURPOSE:To measure the inflammatory reaction in the anterior chamber after lens extraction in a rabbit model and to evaluate the effect of nonsteroidal antiinflammatory drugs (NSAIDs) or steroids on the amount of inflammation as measured by fibrinogen levels in the aqueous humor. SETTING:Animal laboratory, Goldschlege...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2011.12.026
更新日期：2012-05-01 00:00:00
abstract：PURPOSE:To assess how intraocular lens (IOL) formula choice affects refractive outcomes after cataract surgery using IOLMaster biometry. SETTING:Department of Ophthalmology, Gloucestershire Hospitals NHS Foundation Trust, Cheltenham, United Kingdom. DESIGN:Database study. METHODS:Hypothetical prediction errors were ...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2010.07.032
更新日期：2011-01-01 00:00:00
abstract：:Phacoemulsification with intraocular lens (IOL) implantation was performed in the right eye of an 84-year-old woman using a small clear corneal incision. Ten weeks after surgery, the patient fell, which caused traumatic iridodialysis and hyphema with expulsion of the iris through the surgical corneal incision. Apart f...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2004.03.040
更新日期：2004-10-01 00:00:00
abstract：:We describe a variation of stop and chop phacoemulsification. During chopping the chopper's vertical element is depressed posteriorly toward the optic nerve and is placed well within the capsulorhexis margin, leading to in situ chopping. Each fragment is continuously chopped, and the small pieces are stuffed inside th...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章,评审
doi：10.1016/s0886-3350(96)80003-4
更新日期：1996-06-01 00:00:00
abstract：PURPOSE:To evaluate intraocular pressure (IOP) during femtosecond laser-assisted cataract surgery using a fluid-filled interface. SETTING:Ruhr University Eye Clinic, Bochum, Germany. DESIGN:Prospective clinical trial. METHODS:The absolute IOP was measured with a modified Schiotz tonometer before and after laser-assi...
journal_title：Journal of cataract and refractive surgery
pub_type： 临床试验,杂志文章
doi：10.1016/j.jcrs.2012.10.038
更新日期：2013-01-01 00:00:00
abstract：:Over 100 cases of standard extracapsular cataract extraction with intraocular lens implantation were reviewed and the effects of two commercially available pharmacological agents were compared. The treatment groups received either acetylcholine chloride (Miochol) or carbachol (Miostat). Intraocular pressures were meas...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/s0886-3350(89)80008-2
更新日期：1989-03-01 00:00:00
abstract：:According to an online survey, most members of the American Society of Cataract and Refractive Surgery believe that tamsulosin makes cataract surgery more difficult (95%) and increases the risks of surgery (77%). Commonly reported complications of intraoperative floppy-iris syndrome (IFIS) were significant iris trauma...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2008.04.014
更新日期：2008-07-01 00:00:00
abstract：PURPOSE:To compare 2 ultrasound (US) frequencies for phacoemulsification for moderate to hard cataract to determine a frequency that makes phacoemulsification safer and more efficacious. SETTING:Post Graduate Institute of Medical Education and Research, New Delhi, India. DESIGN:Randomized controlled trial. METHODS:P...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jcrs.2019.04.015
更新日期：2019-09-01 00:00:00
abstract：PURPOSE:To assess the degree of capsular bag opacification in human cadaver eyes with silicone intraocular lenses (IOLs), specifically comparing the differences between round-edged IOLs and modern square-edged IOLs. SETTING:John A. Moran Eye Center, University of Utah, USA. DESIGN:Experimental study. METHODS:The eye...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2010.10.058
更新日期：2011-04-01 00:00:00
abstract：:We report a case in which the capsular bag with an intraocular lens (IOL) and a capsular tension ring (CTR) dislocated into the vitreous. The dislocated foldable posterior chamber IOL and CTR were removed with a pars plana vitrectomy and exchanged with a scleral-fixated IOL. No complications occurred intraoperatively ...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2006.05.016
更新日期：2006-10-01 00:00:00
abstract：:Traumatic aniridia and aphakia occurred in the left eye of a 22-year-old man who had had Artisan (Ophtec) phakic intraocular lens (IOL) implantation. Aniridia was probably the result of the relatively large wound used to implant the nonfoldable IOL. Although the eye had severe traumatic damage, vision was recoverable ...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2007.03.037
更新日期：2007-07-01 00:00:00
abstract：PURPOSE:To examine the impact of cataract surgery on older adults' self-reported visual difficulties and compare them with those of patients with cataract who declined surgery over the same period. SETTING:Twelve area practices. METHODS:This was a consecutive chart review over a 6-month period. Primary inclusion crit...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章,多中心研究
doi：10.1016/s0886-3350(02)01846-1
更新日期：2003-05-01 00:00:00
abstract：PURPOSE:To compare the outcomes of topography-guided and wavefront-optimized surgery in patients having laser in situ keratomileusis (LASIK) for myopia. SETTING:Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, and BALGEUN-EYE21 Operation Center, Gwangju, South Korea. DESIGN:Prospective case ...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2019.01.031
更新日期：2019-07-01 00:00:00
abstract：:A retrospective analysis of 40 cases of sulcus-fixated one-piece poly(methyl methacrylate) posterior chamber lenses revealed ten cases (25%) that demonstrated oval deformation of the pupil, similar to the condition associated with anterior chamber lenses. This complication was not noted until several weeks after surge...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/s0886-3350(13)80803-6
更新日期：1990-07-01 00:00:00
abstract：PURPOSE:To evaluate the optical and visual quality in eyes with diffractive intraocular lenses (IOLs) after myopic laser in situ keratomileusis (LASIK). SETTING:Fernández-Vega Ophthalmological Institute, Oviedo, Spain. METHODS:The best corrected visual acuity (BCVA [distance]) at 12.5%, 25.0%, and 100% contrasts unde...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jcrs.2008.12.040
更新日期：2009-05-01 00:00:00
abstract：PURPOSE:To determine whether the yellow filters often used for glare reduction influence retinal straylight measured in healthy eyes. SETTING:Department of Ophthalmology, Antwerp University Hospital, Edegem, Belgium. DESIGN:Prospective case series. METHODS:For each eye, the spherical equivalent (SE) was determined u...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2017.06.033
更新日期：2017-08-01 00:00:00
abstract：:A 43-year-old white woman with a history of multiple ocular surgeries, including 4 penetrating keratoplasties, developed a concentric retrocorneal membrane at the graft periphery in the right eye. A white-light, tandem, scanning confocal microscope using a 24x/0.60 contact objective was used to examine the right eye i...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/s0886-3350(99)00133-9
更新日期：1999-08-01 00:00:00
