Abstract：
:The aim of this study was to investigate orthostatic reactions in females with Rett syndrome (RTT), and also whether the severity of the syndrome had an impact on autonomic reactions. Based on signs of impaired function of the central autonomic system found in RTT, it could be suspected that orthostatic reactions were affected. The orthostatic reactions in 21 females with RTT and 14 normally developed females matched by age were investigated when they rose from a sitting position, and during standing for 3 min. Reactions of the heart, the blood pressure and the time for recovery of systolic blood pressure, were studied in real time, heartbeat by heartbeat, simultaneously. There was no difference between participants with RTT and the normally developed controls regarding general orthostatic reactions (heart rate, systolic and diastolic blood pressure, and mean arterial pressure) when getting up from a sitting position, and when standing erect for 3 min. In the specific immediate response by the heart to standing up, the 30:15 ratio, significantly lower values were found for females with RTT. In the RTT group, the maximum fall of systolic blood pressure showed a tendency to a larger decrease, and the initial decrease in systolic blood pressure was significantly faster. The time for recovery of systolic blood pressure from standing erect did not differ between groups. At baseline the females with RTT had significantly lower systolic blood pressure and a tendency to a higher heart rate. The results do not indicate any autonomic limitations for people with RTT in getting up from a sitting position and standing. The participants with RTT had normal orthostatic reactions indicated by the heart and blood pressure responses when standing erect for 3min. A faster initial drop in systolic blood pressure in people with RTT was notable.
journal_name
Res Dev Disabiljournal_title
Research in developmental disabilitiesauthors
Larsson G,Julu PO,Witt Engerström I,Sandlund M,Lindström Bdoi
10.1016/j.ridd.2013.02.027subject
Has Abstractpub_date
2013-06-01 00:00:00pages
1897-905issue
6eissn
0891-4222issn
1873-3379pii
S0891-4222(13)00095-4journal_volume
34pub_type
杂志文章abstract：:Three experiments were conducted to evaluate the effects of a training program implemented in a community setting for teaching receptive language skills to profoundly mentally retarded persons. In Experiment 1, the program was implemented in a local department store and consisted of a least-to-most intrusive prompting...
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journal_title：Research in developmental disabilities
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pub_type： 临床试验,杂志文章
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doi：10.1016/j.ridd.2009.08.004
更新日期：2010-01-01 00:00:00
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pub_type： 临床试验,杂志文章
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pub_type： 杂志文章
doi：10.1016/j.ridd.2009.09.003
更新日期：2010-01-01 00:00:00
