Abstract:
:This study was undertaken to determine the plasma and erythrocyte profiles of metabolically important nonesterified polyunsaturated fatty acids (PUFA), that is, free fatty acids, in each trimester of pregnancy and in labor. Blood was drawn from patients in the first, second, and third trimester and in labor. Nonesterified polyunsaturated fatty acids were extracted from erythrocytes with chloroform and methanol. The PUFAs from erythrocytes and plasma were then measured in their methylester form using high performance liquid chromatography (HPLC). Plasma levels of all PUFAs were similar in each trimester of pregnancy but levels of linoleic and linolenic acids were higher in laboring patients. Plasma levels of linoleic and arachidonic acid in the n-6 pathway (range 40 to 162 mg/L plasma) were higher than linolenic, eicosapentaenoic, and docosahexaenoic acids measured in the n-3 pathway (range 2.1 to 12.8 mg/L plasma). PUFA levels in erythrocytes were generally higher in the second trimester (range 2.6 to 79.7 mg/100-microL spun erythrocytes). In these erythrocytes, docosahexaenoic acid in the n-3 pathway and linoleic and arachidonic acids in the n-6 pathways were present in the highest amounts. Polyunsaturated fatty acids appear to be absorbed and mobilized in increasing amounts in plasma and erythrocytes with advancing gestational age and labor. This activity appears to be most pronounced in the second trimester. Further investigations into PUFA metabolism and the mechanisms which govern it could lead to a better understanding of the role of these important substances in normal and abnormal pregnancies as well as in the initiation of labor.
journal_name
Am J Perinatoljournal_title
American journal of perinatologyauthors
Ashby AM,Robinette B,Kay HHdoi
10.1055/s-2008-1040766subject
Has Abstractpub_date
1997-11-01 00:00:00pages
623-9issue
10eissn
0735-1631issn
1098-8785journal_volume
14pub_type
杂志文章abstract::The purpose of this study was to examine factors that were associated with uterine rupture in patients attempting vaginal birth after cesarean delivery. We analyzed the results of all patients attempting vaginal birth after cesarean delivery between September 1996 to December 1999 at a single institution using a conte...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2004-828608
更新日期:2004-05-01 00:00:00
abstract::We sought to report an updated incidence, risk factors, and outcome of traumatic facial palsy (TFP) in newborn infants born at King Abdulaziz Medical City (KAMC), Riyadh, Saudi Arabia. We performed a 12-year retrospective study at KAMC. The records of infants with the diagnosis of TFP during the study period were revi...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0030-1253097
更新日期:2010-10-01 00:00:00
abstract:OBJECTIVE:There is limited research exploring the relationship between design and patient safety outcomes, especially in maternal and neonatal care. We employed design thinking methodology to understand how the design of labor and delivery units impacts safety and identified spaces and systems where improvements are ne...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0039-1685494
更新日期:2020-05-01 00:00:00
abstract:OBJECTIVE:We aim to quantify the impact of obesity on maternal intensive care unit (ICU) admission. MATERIALS AND METHODS:This is a population-based, retrospective cohort study of Ohio live births from 2006 to 2012. The primary outcome was maternal ICU admission. The primary exposure was maternal body mass index (BMI)...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0038-1660460
更新日期:2018-12-01 00:00:00
abstract::We present an unusual case in which sonographic assessment at 33 weeks' gestation, 5 weeks following a normal fetal anatomical survey and biometry, demonstrated a large, irregular-shaped, echogenic, suprasellar midline intracranial mass occupying the anterior and middle fossas. Associated severe obstructive hydrocepha...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-994064
更新日期:1998-01-01 00:00:00
abstract::We present a case of a premature infant with early-onset necrotizing enterocolitis as the presenting symptom of familial dysautonomia. The diagnosis of familial dysautonomia in the neonatal period is usually rare and difficult, because many of the symptoms may be mild or nonspecific, whereas other characteristic signs...
journal_title:American journal of perinatology
pub_type: 杂志文章,评审
doi:10.1055/s-2005-871525
更新日期:2005-10-01 00:00:00
abstract::The ability of vibratory acoustic stimulation to shorten the duration of antepartum fetal heart rate monitoring was investigated by a randomized controlled trial. Vibratory acoustic stimulation did not shorten the overall duration of testing. This failure to improve the performance of antepartum monitoring appeared to...
journal_title:American journal of perinatology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1055/s-2007-999489
更新日期:1990-07-01 00:00:00
abstract::As new information about coronavirus disease 2019 (COVID-19) is rapidly discovered, clinicians are better equipped to make informed decisions for their patients. While current research suggests COVID-19 viral antigen is not found in vaginal secretions, its detectability in the female lower genital tract may have clini...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0040-1713665
更新日期:2020-09-01 00:00:00
abstract:OBJECTIVE:To reduce nonactionable oximeter alarms by 80% without increasing time infants were hypoxemic (oxygen saturation [SpO2] ≤ 80%) or hyperoxemic (SpO2 > 95% while on supplemental oxygen). STUDY DESIGN:In 2015, a multidisciplinary team at Connecticut Children's Medical Center initiated a quality improvement proj...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0038-1653945
更新日期:2018-11-01 00:00:00
abstract::Objective To compare maternal birth complications early versus late in the academic year and to evaluate the impact of resident work hour limitation on the "July effect." Study Design We conducted a retrospective, population-based cohort study of 628,414 singleton births in Washington State from 1987 to 2012 measuring...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0037-1598244
更新日期:2017-07-01 00:00:00
abstract::We describe a case of transient hyperinsulinism in an asphyxiated newborn infant with hypoglycemia. Although hypoglycemia in birth asphyxiated infants is generally attributed to depletion of glycogen stores, we observed severe hyperinsulinism associated with the hypoglycemia. The hypoglycemia was refractory to high gl...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2001-15504
更新日期:2001-06-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to evaluate the effectiveness of vaginal progesterone in reducing adverse neonatal outcome due to preterm birth (PTB) in low-risk pregnant women with a short cervical length (CL). STUDY DESIGN:Women with a singleton pregnancy without a history of PTB underwent CL measurement a...
journal_title:American journal of perinatology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1055/s-0035-1547327
更新日期:2015-08-01 00:00:00
abstract::There were 107 episodes of pyelonephritis associated with pregnancy or the early puerperium occurring in 103 gravidas investigated retrospectively for information concerning prematurity, low birthweight, and antibiotic susceptibility patterns in the recovered microorganisms. No difference was found in the incidence of...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-999800
更新日期:1987-10-01 00:00:00
abstract::Neonatal alloimmune neutropenia (NAN) results from neutrophil destruction by transplacental maternal neutrophil-specific immunoglobulin G (IgG) antibodies directed against the antigen inherited from the father. Treatment is usually based on recombinant human granulocyte colony-stimulating factor (G-CSF) and prevention...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0030-1270113
更新日期:2011-06-01 00:00:00
abstract::The Roberts-SC phocomelia syndrome (pseudothalidomide syndrome) is a rare, usually lethal condition involving short limbs and occasional hydrocephalus. Presented is a case in which prenatal sonographic findings were highly suggestive of this syndrome, although not definite. In this fetus, findings of hydrocephalus, sh...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-999392
更新日期:1991-07-01 00:00:00
abstract:OBJECTIVE:Normal initial blood glucose values in healthy newborns are not well defined and are subject to controversy. Despite substantive research, there is no single initial value of glucose that can be used with certainty of safety in newborns, and thus various protocols and cutoffs have been proposed. STUDY DESIGN...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0038-1667293
更新日期:2019-01-01 00:00:00
abstract::The presence of the maternal warm antibody in pregnancy should not be ignored. As there is risk of both maternal and fetal anemia, both patients need to be followed for the development of such. Serial complete blood counts in the mother and treatment if significant fetal anemia develops should be considered. Serial am...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-994196
更新日期:1996-01-01 00:00:00
abstract:OBJECTIVE:This study assessed the impact of a nurse simulation training program on perception of kangaroo mother care (KMC) value and transfer skill competency. STUDY DESIGN:An 8-item Likert scale skill survey tool and a 24-item Likert developmental care survey tool were used in a prospective cohort study to analyze p...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0034-1371359
更新日期:2014-11-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to investigate whether maternal bronchial asthma increases the risk for long-term respiratory morbidity of the offspring. STUDY DESIGN:A population-based cohort study compared the incidence of long-term pediatric hospitalizations due to respiratory disease of the offspring of ...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0038-1639507
更新日期:2018-09-01 00:00:00
abstract::Intra-oral enteric duplication cysts are rare. We recently treated two infants with prenatally diagnosed large sublingual enteric duplication cysts. Antenatal aspiration of the cyst was attempted in one infant without success. Because of the potential for airway obstruction and respiratory distress at delivery, prepar...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-994119
更新日期:1997-03-01 00:00:00
abstract::A 27-year-old primigravida women was referred for ultrasound studies at 32 weeks' gestation because of the suspicion of fetal ventriculomegaly. Sonographic examination of the fetal brain found a marked shift of the midline, with enlarged left hemisphere and ipsilateral occipital horn, and abnormal convolutions. A 3500...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-999330
更新日期:1991-01-01 00:00:00
abstract::To study a possible relation between the use of postnatal glucocorticoids and the incidence and severity of retinopathy of prematurity (ROP), we conducted a retrospective study over a 4-year period that compared data of 161 preterm infants treated with hydrocortisone for bronchopulmonary dysplasia (BPD) with the data ...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2000-13437
更新日期:2000-01-01 00:00:00
abstract::In the present study we examined whether the vitamin D3 metabolites, 25-hydroxyvitamin D and 1-25-dihydroxycholecalciferol affected the production of the prostaglandins PGE2 and PGF2 alpha in human fetal membranes and placenta in vitro. Human amnion, chorion, decidual, and placental cells were maintained in primary mo...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-999564
更新日期:1989-04-01 00:00:00
abstract:OBJECTIVE:Securing an arterial line to monitor continuous blood pressure (BP) is difficult in infants. We aimed to reveal the extent of discrepancies between oscillometric and direct BP. STUDY DESIGN:Infants who required continuous BP monitoring were prospectively enrolled. Direct and indirect BP were simultaneously r...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0034-1383851
更新日期:2015-02-01 00:00:00
abstract::There is increasing concern about Chlamydia trachomatis infection during pregnancy, because of reports of increased maternal, fetal, and neonatal risks. Amniotic fluid is known to possess antibacterial activity and has recently been shown to inhibit formation of chlamydial inclusions in McCoy cell culture. To further ...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-999341
更新日期:1991-01-01 00:00:00
abstract::The objective of this paper is to determine whether acyclovir suppression provides a greater cost savings over no medical therapy in the management of recurrent genital herpes (HSV) in pregnancy. Estimates of the risk of HSV recurrence and cesarean delivery rates in acyclovir-treated and -untreated patients and freque...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-993900
更新日期:1998-01-01 00:00:00
abstract::Twenty-five patients undergoing nipple stimulation contraction stress tests were enrolled in this study. Plasma 13,14-dihydro, 15-keto prostaglandin F2 alpha and plasma prolactin concentrations were analyzed before and during the contraction stress tests. Prolactin concentrations were significantly higher (p less than...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-999444
更新日期:1990-01-01 00:00:00
abstract:OBJECTIVE:To determine the effect of increasing maternal obesity, including superobesity (body mass index [BMI] ≥ 50 kg/m2), on perinatal outcomes in women with diabetes. STUDY DESIGN:Retrospective cohort study of birth records for all live-born nonanomalous singleton infants ≥ 37 weeks' gestation born to Missouri res...
journal_title:American journal of perinatology
pub_type: 杂志文章
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更新日期:2014-03-01 00:00:00
abstract:OBJECTIVE:To determine the accuracy of clinically estimated fetal weight (CEFW) in patients with gestational diabetes (GDM), pregestational diabetes (DM), and obesity. STUDY DESIGN:This is a retrospective analysis of Consortium of Safe Labor data. Subjects were classified into six groups: DM, DM and obese, GDM, GDM an...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0033-1334450
更新日期:2014-01-01 00:00:00
abstract::The purpose of this study was to determine the short-term outcome of newborns less than 30 weeks gestation when there is definite placental histologic chorioamnionitis. A retrospective analysis was performed of records of all neonates delivered at our institution from January 1989 through January 1999. This informatio...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2005-865020
更新日期:2005-04-01 00:00:00