当前位置： SCI文献检索 > UROLOGY期刊下所有文献 > Transurethral alprostadil as therapy for patients who withdrew from or failed prior intracavernous injection therapy.

Transurethral alprostadil as therapy for patients who withdrew from or failed prior intracavernous injection therapy.

Abstract：

OBJECTIVES:Patients experiencing erectile dysfunction who fail intracavernous injection (ICI) therapy are commonly believed to have exhausted pharmacologic options. We evaluated the efficacy and safety of transurethral alprostadil (MUSE) in patients experiencing erectile dysfunction who underwent prior ICI therapy (alprostadil, papaverine, phentolamine, or a combination of these). METHODS:Of the 1511 patients enrolled in a multicenter trial of transurethral alprostadil, 452 (30%) reported prior ICI therapy and its effects. These patients tested up to four dose levels of transurethral alprostadil in the clinic, and those who achieved an erection satisfactory for intercourse were treated at home in a double-blind, placebo-controlled trial. RESULTS:Prior ICI therapy was reported to be "not effective" by 95 of 452 patients (21%), "sometimes effective" by 119 of 452 (26%), and "effective" by 238 of 452 (53%). In patients reporting ICI therapy as "not effective," 58% achieved an erection sufficient for intercourse following transurethral alprostadil therapy in the clinic; 47% of these responsive patients reported successful sexual intercourse after transurethral alprostadil therapy during home treatment. For patients reporting ICI therapy as "sometimes effective" or "effective," 68% achieved an erection sufficient for intercourse following transurethral alprostadil therapy in the clinic setting and 67% of these responsive patients reported successful intercourse following transurethral alprostadil therapy at home. Few adverse effects were encountered. The most common adverse effect was penile pain, which occurred with 7.8% of administrations. CONCLUSIONS:Transurethral alprostadil therapy is an effective therapeutic option for patients with erectile dysfunction and may even "rescue" some patients who have failed prior intracavernous injection therapy.

journal_name

Urology

journal_title

Urology

authors

Engel JD,McVary KT

doi

10.1016/s0090-4295(98)00093-4

subject

Has Abstract

pub_date

1998-05-01 00:00:00

pages

687-92

issue

5

eissn

0090-4295

issn

1527-9995

pii

S0090-4295(98)00093-4

journal_volume

51

pub_type

临床试验,杂志文章,多中心研究

相关文献

UROLOGY文献大全
  • Efficacy compared between caudal block and periprostatic local anesthesia for transrectal ultrasound-guided prostate needle biopsy.

    abstract：OBJECTIVES:To investigate the clinical efficacy of a caudal block compared with periprostatic local anesthesia for transrectal ultrasound-guided multicore prostate needle biopsy. METHODS:A total of 100 patients who had undergone initial prostate biopsy using a systematic five-region biopsy by a single operator were in...

    journal_title：Urology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.urology.2006.02.025

    authors： Horinaga M,Nakashima J,Nakanoma T

    更新日期：2006-08-01 00:00:00

  • Pre- and postoperative urodynamic findings in patients after a bulbourethral composite suspension with intraoperative urodynamically controlled sling tension adjustment for postprostatectomy incontinence.

    abstract：OBJECTIVES:To compare pre- and postoperative urodynamic findings in patients with a bulbourethral composite suspension and intraoperative urodynamically controlled sling tension adjustment. METHODS AND PATIENTS:All data were prospectively collected from 10 patients (mean age 66 years) who successfully underwent bulbou...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/j.urology.2011.11.012

    authors： Horstmann M,Fischer I,Vollmer C,Horton K,Kurz M,Padevit C,John H

    更新日期：2012-03-01 00:00:00

  • Single-center comparison of complications in laparoscopic and percutaneous radiofrequency ablation with ultrasound guidance for renal tumors.

    abstract：OBJECTIVE:To report on postoperative complications associated with laparoscopic radiofrequency ablation (LRFA) and percutaneous radiofrequency ablation (PRFA) in a single-center experience. METHODS:We conducted a retrospective review of medical records for patients undergoing LRFA or PRFA between February 2006 and Mar...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/j.urology.2012.01.085

    authors： Lian H,Guo H,Zhang G,Yang R,Gan W,Li X,Ji C,Liu J

    更新日期：2012-07-01 00:00:00

  • Testicular extrusion due to scrotoschisis.

    abstract：:We present the eighth case of testicular extrusion through a congenital defect in the scrotal wall, along with a review of the published reports and a discussion of its possible embryogenesis. ...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/s0090-4295(02)02003-4

    authors： Togami J,Radhakrishnan J

    更新日期：2002-12-01 00:00:00

  • Fluorescence in situ hybridization performed on exfoliated urothelial cells in patients with transitional cell carcinoma of the bladder.

    abstract：OBJECTIVES:To evaluate comparatively fluorescence in situ hybridization (FISH) and cytology performed on exfoliated urothelial cells obtained from voided urine and bladder washings as a method of diagnosis and follow-up in patients with transitional cell carcinoma (TCC) of the bladder. METHODS:Thirty patients with con...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/j.urology.2003.08.026

    authors： Degtyar P,Neulander E,Zirkin H,Yusim I,Douvdevani A,Mermershtain W,Kaneti J,Manor E

    更新日期：2004-02-01 00:00:00

  • Loss of DMBT1 expression in human prostate cancer and its correlation with clinical progressive features.

    abstract：OBJECTIVES:To investigate alterations of DMBT1 in prostate cancer and determine the correlation of its alterations to the clinicopathologic features of prostate cancer. DMBT1 has been proposed as a candidate tumor suppressor gene for epithelial cancer. METHODS:The alterations of DMBT1 expression after treatment with D...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/j.urology.2010.09.023

    authors： Du J,Guan M,Fan J,Jiang H

    更新日期：2011-02-01 00:00:00

  • Left transperitoneal laparoendoscopic single-site radical nephrectomy in the presence of a duplicated inferior vena cava with associated complex renal vascular anomalies.

    abstract：:Laparo-endoscopic single-site (LESS) renal surgery is steadily gaining momentum. LESS by itself is technically challenging, with a potentially increased procedural risk, and the presence of major vascular anomaly may increase the risk of intraoperative mishap. Here we present a case of left transperitoneal LESS radica...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/j.urology.2011.12.007

    authors： Wang L,Wu Z,Cai C,Liu B,Yang Q,Sun Y

    更新日期：2012-03-01 00:00:00

  • Positive posterior margin of needle biopsy cores is an independent predictor for extracapsular extension in retropubic radical prostatectomy.

    abstract：OBJECTIVE:To introduce the new preoperative parameter as a predictor for extracapsular extension (ECE), we defined the presence of tumor at the stump of the rectum side on prostate needle biopsy as a positive posterior margin (PPM), and speculated that PPM is related to ECE. METHODS:This retrospective study was conduc...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/j.urology.2012.12.050

    authors： Yamanaka H,Matsumoto K,Obata J,Ninomiya A,Mukai K,Nakamura S

    更新日期：2013-05-01 00:00:00

  • Outcome of buccal mucosal graft urethroplasty for long and repeated stricture repair.

    abstract：OBJECTIVES:To evaluate the efficacy of one-stage buccal mucosal tubed graft in long and repeated urethroplasty. METHODS:Thirty-four patients with long and repeated strictures of the urethra underwent buccal mucosal urethroplasty from 2000 to 2003. For all patients, one-stage buccal mucosal tubed graft urethroplasty wa...

    journal_title：Urology

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.urology.2006.09.069

    authors： Mehrsai A,Djaladat H,Salem S,Jahangiri R,Pourmand G

    更新日期：2007-01-01 00:00:00

  • Incidence of Visible Hematuria Among Antithrombotic Agents: A Systematic Review of Over 175,000 Patients.

    abstract：OBJECTIVE:To determine the probability of visible hematuria with antithrombotic agents and to evaluate association of urologic etiology in antithrombotic-related hematuria. METHODS:Preferred Reporting Items in Systematic Reviews and Meta-Analyses guidelines were followed to conduct a systematic review using search eng...

    journal_title：Urology

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.urology.2017.11.023

    authors： Bhatt NR,Davis NF,Nolan WJ,Flynn RJ,McDermott T,Thomas AZ,Manecksha RP

    更新日期：2018-04-01 00:00:00

  • High- vs low-power holmium laser lithotripsy: a prospective, randomized study in patients undergoing multitract minipercutaneous nephrolithotomy.

    abstract：OBJECTIVE:To determine the efficacy and safety of high-power holmium: yttrium aluminum-garnet (Ho:YAG) laser lithotripsy for multitract modified minimally invasive percutaneous nephrolithotomy (MPCNL) in the treatment of patients with large staghorn renal calculi. METHODS:A randomized, prospective study was conducted....

    journal_title：Urology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.urology.2011.08.036

    authors： Chen S,Zhu L,Yang S,Wu W,Liao L,Tan J

    更新日期：2012-02-01 00:00:00

  • Continent urinary reconstruction versus ileal conduit: a contemporary single-institution comparison of perioperative morbidity and mortality.

    abstract：OBJECTIVES:To compare postoperative morbidity and mortality in a concurrent and contemporary series of patients who underwent radical cystectomy with ileal conduit versus orthotopic neobladder. METHODS:The data of 198 patients were reviewed, 117 with orthotopic reconstruction and 81 with ileal conduit during a 5-year ...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/s0090-4295(99)00619-6

    authors： Parekh DJ,Gilbert WB,Koch MO,Smith JA Jr

    更新日期：2000-06-01 00:00:00

  • Antiandrogen withdrawal syndrome with cyproterone acetate.

    abstract：OBJECTIVES:To determine whether the antiandrogen withdrawal syndrome occurs with the steroidal antiandrogen cyproterone acetate. METHODS:Cyproterone acetate was withheld in 12 patients with progressing androgen-independent metastatic prostate cancer. Eight patients had been receiving cyproterone acetate concomitant wi...

    journal_title：Urology

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0090-4295(98)00354-9

    authors： Sella A,Flex D,Sulkes A,Baniel J

    更新日期：1998-12-01 00:00:00

  • Adenotonsillectomy Normalizes Hormones and Urinary Electrolytes in Children With Nocturnal Enuresis and Sleep-Disordered Breathing.

    abstract：OBJECTIVE:To assess (1) plasma levels of antidiuretic hormone (ADH) and brain natriuretic peptide (BNP) and urinary levels of electrolytes in children with sleep disordered breathing (SDB), with or without nocturnal enuresis (NE), and (2) the effect of adenotonsillectomy (T&A) on urinary electrolytes and the secretion ...

    journal_title：Urology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.urology.2015.04.011

    authors： Kovacevic L,Lu H,Wolfe-Christensen C,Abdulhamid I,Thottam PJ,Lulgjuraj M,Madgy DN,Lakshmanan Y

    更新日期：2015-07-01 00:00:00

  • Gastrointestinal hemorrhage as first manifestation of metastatic testicular tumor.

    abstract：:We report a case of a man with a testicular mixed germ cell tumor in whom the first symptom was severe anemia secondary to upper gastrointestinal bleeding from a metastatic pure choriocarcinoma. He underwent ileal enterectomy, radical orchiectomy, and several cycles of chemotherapy (cisplatin, etoposide, and bleomycin...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/j.urology.2005.06.102

    authors： Shariat SF,Duchene D,Kabbani W,Mucher Z,Lotan Y

    更新日期：2005-12-01 00:00:00

  • Effect of hyperglycemia on expression of aquaporins in the rat vagina.

    abstract：OBJECTIVE:To investigate the effect of hyperglycemia on the expression of the aquaporin (AQP) isoforms in the diabetic rat vagina. METHODS:Female Sprague-Dawley rats (230-240 g, n = 45) were divided into control (n = 10) and experimental (n = 35) groups. Diabetes in the experimental group was induced by intraperitonea...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/j.urology.2012.03.026

    authors： Lee HS,Li Z,Kim SO,Ahn K,Kim NN,Park K

    更新日期：2012-09-01 00:00:00

  • Human bladder smooth muscle cell damage in disturbed oxygen tension.

    abstract：OBJECTIVE:To characterize human bladder smooth muscle cell reactions to disturbed oxygen tension. Clinical studies have shown a close correlation between bladder ischemia and lower urinary tract symptoms in elderly patients. MATERIALS AND METHODS:Confluent cultured human bladder smooth muscle cells were incubated unde...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/j.urology.2011.06.034

    authors： Azadzoi KM,Yalla SV,Siroky MB

    更新日期：2011-10-01 00:00:00

  • Incidence of upper tract abnormalities in patients with neurovesical dysfunction secondary to multiple sclerosis: analysis of risk factors at initial urologic evaluation.

    abstract：OBJECTIVES:To determine the incidence of upper tract abnormalities on renal ultrasonography in patients with multiple sclerosis (MS) referred for urologic evaluation, as well as to identify any risk factors present on the basis of the historical information and urodynamic findings. METHODS:Data were derived from all p...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/j.urology.2004.11.038

    authors： Lemack GE,Hawker K,Frohman E

    更新日期：2005-05-01 00:00:00

  • A single dose of 240 mg gentamicin during transrectal prostate biopsy significantly reduces septic complications.

    abstract：OBJECTIVE:To evaluate whether the addition of a single dose of an aminoglycoside to a fluoroquinolone-based prophylaxis regime would decrease septic complications associated with transrectal prostate biopsy. METHODS:A retrospective survey of all patients undergoing transrectal ultrasound guided prostate biopsy (TRUS-P...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/j.urology.2013.01.074

    authors： Lorber G,Benenson S,Rosenberg S,Gofrit ON,Pode D

    更新日期：2013-11-01 00:00:00

  • Establishment of a Web-based System for Collection of Patient-reported Outcomes After Radical Prostatectomy in a Statewide Quality Improvement Collaborative.

    abstract：OBJECTIVE:To report on the establishment of a unified, electronic patient-reported outcome (PRO) infrastructure and pilot results from the first 5 practices enrolled in the web-based collection system developed by the Michigan Urological Surgery Improvement Collaborative. MATERIALS AND METHODS:Eligible patients were t...

    journal_title：Urology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.urology.2017.04.058

    authors： Lucas SM,Kim TK,Ghani KR,Miller DC,Linsell S,Starr J,Peabody JO,Hurley P,Montie J,Cher ML,Michigan Urological Surgery Improvement Collaborative.

    更新日期：2017-09-01 00:00:00

  • Microsurgical testis-sparing surgery in small testicular masses: seven years retrospective management and results.

    abstract：OBJECTIVE:To retrospectively evaluate the clinical outcomes of 20 patients diagnosed with a nonpalpable or small testicular mass (2 cm) at 2 academic urological department. Testis-sparing surgery (TSS) is currently performed routinely for the management of nonpalpable testicular masses. High reliability of frozen secti...

    journal_title：Urology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.urology.2011.12.039

    authors： De Stefani S,Isgrò G,Varca V,Pecchi A,Bianchi G,Carmignani G,Derchi LE,Micali S,Maccio L,Simonato A

    更新日期：2012-04-01 00:00:00

  • Failed posterior urethroplasty: lessons learned.

    abstract：OBJECTIVES:To determine the factors contributing to unsuccessful results after posterior urethroplasty and to establish some guidelines for its prevention. METHODS:From 1977 through 2000, 130 patients (3 to 58 years old) underwent 145 anastomotic urethroplasty procedures for post-traumatic posterior urethral distracti...

    journal_title：Urology

    pub_type： 杂志文章,评审

    doi：10.1016/s0090-4295(03)00573-9

    authors： Koraitim MM

    更新日期：2003-10-01 00:00:00

  • The Association of the Mayo Adhesive Probability (MAP) Score With Total Operative Time in Patients Undergoing Hand-assisted Laparoscopic Donor Nephrectomy.

    abstract：OBJECTIVE:To assess whether donor kidney Mayo Adhesive probability (MAP) score is associated with (total operative time) ORT in patients undergoing hand-assisted laparoscopic donor nephrectomy (HALDN). METHODS:Three hundred and thirty-one patients undergoing HALDN were reviewed. Donor kidney MAP scores were recorded b...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/j.urology.2018.10.041

    authors： Cockerill KJ,Young S,T Ball C,Custer K,Taner CB,Perry DK,Thiel DD

    更新日期：2019-02-01 00:00:00

  • Short-term outcomes after cryosurgical ablation of the prostate in men with recurrent prostate carcinoma following radiation therapy.

    abstract：OBJECTIVES:Cryosurgical ablation of the prostate represents a possibly efficacious method of treating prostate carcinoma in men failing radiation therapy. In addition to eradicating the disease, cryosurgery has the potential to avoid some of the morbidity associated with other treatment modalities. Therefore, a prospec...

    journal_title：Urology

    pub_type： 临床试验,杂志文章

    doi：10.1016/S0090-4295(99)80300-8

    authors： Bales GT,Williams MJ,Sinner M,Thisted RA,Chodak GW

    更新日期：1995-11-01 00:00:00

  • Analysis of G/A polymorphism in the androgen response element I of the PSA gene and its interactions with the androgen receptor polymorphisms.

    abstract：OBJECTIVES:To compare the in vitro functional activity of the prostate-specific antigen (PSA) androgen response element (ARE) I alleles alone or in combination with androgen receptor (AR) polymorphisms and to determine the association of ARE I alleles with serum PSA in men without clinical prostatic disease. Data are c...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/s0090-4295(02)02414-7

    authors： Rao A,Chang BL,Hawkins G,Hu JJ,Rosser CJ,Hall MC,Meyers DA,Xu J,Cramer SD

    更新日期：2003-04-01 00:00:00

  • Simultaneous closure of low cutaneous loop ureterostomies and excision of congenital ureterovesical junction strictures.

    abstract：:A case report of a child is presented in which double sectioing of the lower ureter was required to close simultaneously low cutaneous loop ureterostomies and to excise congenital ureterovesical junction strictures. One ureteroneocystostomy required revision. The vasculature of the ureteral segments was preserved by n...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/0090-4295(75)90315-5

    authors： Redman JF,Bissada NK,Turley JT

    更新日期：1975-01-01 00:00:00

  • Simultaneous augmentation ileo-cystoplasty in renal transplantation.

    abstract：INTRODUCTION:Renal transplantation is not contraindicated in end-stage renal disease developing as a result of complication of overactive bladder with uninhibited detrusor contractions. As an amendatory surgical approach, augmentation ileo-cystoplasty is the preferred option to achieve a low intravesical storage pressu...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/j.urology.2007.09.045

    authors： Dinckan A,Turkyilmaz S,Tekin A,Erdogru T,Kocak H,Mesci A,Gurkan A,Erdogan O,Tuncer M,Demirbas A

    更新日期：2007-12-01 00:00:00

  • Diffuse cystitis glandularis. Associated with adenocarcinomatous change.

    abstract：:Although cystitis glandularis has been considered a premalignant lesion, the instance of cystitis glandularis progression to adenocarcinoma or cystitis glandularis associated with adenocarcinomatous change is rare. This article includes 4 cases of neurogenic bladder with urinary diversion for different periods of time...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/0090-4295(80)90484-7

    authors： Lin JI,Yong HS,Tseng CH,Marsidi PS,Choy C,Pilloff B

    更新日期：1980-04-01 00:00:00

  • Antibiotic Prophylaxis Prescribing Patterns of Pediatric Urologists for Children with Vesicoureteral Reflux and other Congenital Anomalies of the Kidney and Urinary Tract.

    abstract：OBJECTIVE:To determine pediatric urologists' antibiotic prophylaxis prescribing practices for children with vesicoureteral reflux (VUR) and other congenital anomalies of the kidney and urinary tract (CAKUT). METHODS:Web-based survey of pediatric urologists about their practice of antibiotic prophylaxis in children wit...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/j.urology.2019.11.013

    authors： Hamdy RF,Pohl HG,Forster CS

    更新日期：2020-02-01 00:00:00

  • Bazex syndrome: acrokeratosis paraneoplastica in association with simultaneous multiple genitourinary tumors.

    abstract：:We report a patient with Bazex (Bazex-Dupre-Christol) syndrome in association with multifocal basal cell carcinoma, epidermoid carcinoma of the lung, adenocarcinoma of the prostate, and possibly undifferentiated carcinoma of the bladder. To our knowledge, this is the first report of a patient with Bazex syndrome that ...

    journal_title：Urology

    pub_type： 杂志文章

    doi：10.1016/s0090-4295(00)00529-x

    authors： Atilla MK,Yllmaz Y,Bekerecioğlu M,Akpolat N,Kösem M,Aydin S

    更新日期：2000-07-01 00:00:00