Microvesicle protein levels are associated with increased risk for future vascular events and mortality in patients with clinically manifest vascular disease.


BACKGROUND AND OBJECTIVES:Microvesicles (MVs) are small membrane vesicles that are involved in atherotrombotic processes. In the present study, we evaluated the risk of MV protein levels on the occurrence of new vascular events in patients with clinically manifest vascular disease. METHODS:In this cohort study 1060 patients were prospectively followed for the occurrence of a new vascular event or death (median follow up 6.4 years, interquartile range 5.2-7.3 years). MVs were isolated from plasma and MV protein levels of Cystatin C, Serpin G1, Serpin F2 and CD14 were measured. Multivariable Cox proportional hazards models were used to estimate the risk for new vascular events, vascular mortality and all-cause mortality. During follow up 136 vascular events occurred, 65 vascular mortality and 114 all-cause mortality. RESULTS:An increase in 1 standard deviation (SD) of Cystatin C MV level was related to an increased risk for myocardial infarction (HR 1.49; 95%CI 1.20-1.86), vascular mortality (HR 1.48; 95%CI 1.17-1.86), vascular events (HR 1.27; 1.07-1.52) and all-cause mortality (HR 1.41; 95%CI 1.18-1.69). Serpin F2 MV levels were related to an increased risk for myocardial infarction (HR 1.22; 95%CI 1.00-1.51), vascular mortality (HR 1.25; 95%CI 1.00-1.56), and all-cause mortality (HR 1.22; 95% CI 1.03-1.45). CD14 MV levels were related to an increased risk for myocardial infarction (HR 1.55; 95%CI 1.27-1.91), vascular mortality (HR 1.37; 95%CI 1.10-1.70), vascular events (HR 1.32; 95%CI 1.12-1.55), all-cause mortality (HR 1.36; 95%CI 1.15-1.62) and occurrence of ischemic stroke (HR 1.32; 95%CI 1.00-1.74). CONCLUSIONS:Cystatin C, Serpin F2 and CD14 MV levels are related to an elevated risk for future vascular events and mortality in patients with clinically manifest vascular disease.


Int J Cardiol


Kanhai DA,Visseren FL,van der Graaf Y,Schoneveld AH,Catanzariti LM,Timmers L,Kappelle LJ,Uiterwaal CS,Lim SK,Sze SK,Pasterkamp G,de Kleijn DP,SMART Study Group.




Has Abstract


2013-10-03 00:00:00














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    journal_title:International journal of cardiology

    pub_type: 杂志文章,多中心研究


    authors: Hart EA,Jansen R,Meijs TA,Bouma BJ,Riezebos RK,Tanis W,van Boven WJ,Hindori V,Wiersma N,Dessing T,Westerink J,Chamuleau SA

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  • The impact of early administration of low-dose atorvastatin treatment on inflammatory process, in patients with unstable angina and low cholesterol level.

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    authors: Tousoulis D,Antoniades C,Katsi V,Bosinakou E,Kotsopoulou M,Tsioufis C,Stefanadis C

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  • Statins reduce relapse rate in Takayasu arteritis.

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    authors: Kwon OC,Oh JS,Park MC,Hong S,Lee CK,Yoo B,Kim YG

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    pub_type: 信件


    authors: Finsterer J,Stöllberger C,Gaismayer K,Janssen B

    更新日期:2006-01-26 00:00:00

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    pub_type: 杂志文章


    authors: Fukuma N,Oikawa K,Aisu N,Kato K,Kimura-Kato YK,Tuchida T,Mabuchi K,Takano T

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    authors: Shrivastava S,Radhakrishnan S

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    pub_type: 杂志文章


    authors: Milwidsky A,Kivity S,Kopel E,Klempfner R,Berkovitch A,Segev S,Sidi Y,Goldenberg I,Maor E

    更新日期:2014-05-01 00:00:00

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    authors: Marasigan V,Perry I,Bennett K,Balanda K,Capewell S,O' Flaherty M,Kabir Z

    更新日期:2020-07-01 00:00:00

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    authors: Tang KH,Chan WW,Chiu RC,Tse KK,Wong PH,Sanderson JE

    更新日期:2005-06-22 00:00:00

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    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Taneja AK,Gaze D,Coats AJ,Dumitrascu D,Spinarova L,Collinson P,Roughton M,Flather MD,SENIORS Investigators.

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    authors: Manolis AG,Akridas CC,Chatzis DG,Gerakios E,Dimopoulos C

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    journal_title:International journal of cardiology

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    authors: Zhang YH,Xu SC

    更新日期:1994-12-01 00:00:00

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    pub_type: 杂志文章


    authors: Wysocki H,Kazmierczak M,Wykretowicz A,Szczepanik A,Minczykowski A

    更新日期:1998-01-05 00:00:00

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    authors: Hayer MK,Radhakrishnan A,Price AM,Baig S,Liu B,Ferro CJ,Captur G,Townend JN,Moon JC,Edwards NC,Steeds RP

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    authors: Peverill RE,Harper RW,Smolich JJ

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    abstract:BACKGROUND:Syncope has been associated with increased risk of sudden cardiac arrest (SCA) in specific patient populations, such as hypertrophic cardiomyopathy, heart failure, and long QT syndrome, but data are lacking on the risk of SCA associated with syncope among patients with coronary artery disease (CAD), the most...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,多中心研究


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    更新日期:2017-03-15 00:00:00

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    pub_type: 杂志文章


    authors: Hollebecque A,Lanoy E,Troallen F,Soulat-Dufour L,Massard C,Bahleda R,Varga A,Gazzah A,Postel-Vinay S,Ribrag V,Deutsch E,Angevin E,Boccara F,Cohen A,Soria JC,Ederhy S

    更新日期:2016-07-01 00:00:00

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    pub_type: 杂志文章


    authors: Tousoulis D,Tentolouris C,Bosinakou E,Apostolopoulos T,Kyriakides M,Toutouzas P

    更新日期:1996-10-25 00:00:00

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    abstract:BACKGROUND:Dendritic cells (DCs) are the most potent antigen-presenting cells and play a central role in initiating the primary immune response. Although increasing evidence supports immune-mediated inflammation plays an important role in the pathophysiology of heart failure, little is known regarding the source and me...

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    authors: Sugi Y,Yasukawa H,Kai H,Fukui D,Futamata N,Mawatari K,Oba T,Nagata N,Kyougoku S,Koga M,Imaizumi T

    更新日期:2011-03-03 00:00:00

  • Endurance training attenuates doxorubicin-induced cardiac oxidative damage in mice.

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    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Ascensão A,Magalhães J,Soares J,Ferreira R,Neuparth M,Marques F,Oliveira J,Duarte J

    更新日期:2005-04-28 00:00:00

  • Mid-term outcomes after percutaneous interventions in coronary bifurcations.

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    journal_title:International journal of cardiology

    pub_type: 杂志文章,多中心研究


    authors: Zimarino M,Briguori C,Amat-Santos IJ,Radico F,Barbato E,Chieffo A,Cirillo P,Costa RA,Erglis A,Gamra H,Gil RJ,Kanic V,Kedev SA,Maddestra N,Nakamura S,Pellicano M,Petrov I,Strozzi M,Tesorio T,Vukcevic V,De Caterina

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    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Petrasko M,Horak J,Prerovsky I

    更新日期:1994-05-01 00:00:00

  • Exercise-induced hypoxia predicts hypobaric hypoxia during flight in patients after Fontan operation.

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    pub_type: 杂志文章


    authors: Aytemir K,Aksöyek S,Ozer N,Gürlek A,Oto A

    更新日期:1998-06-01 00:00:00

  • A monounsaturated fatty acid (oleic acid) modulates electrical activity in atrial myocytes with calcium and sodium dysregulation.

    abstract:BACKGROUND:Obesity and metabolic syndrome are important risk factors for atrial fibrillation. High plasma concentrations of monounsaturated fatty acids, including oleic acid (OLA), are frequently noted in obese individuals and patients with metabolic syndrome. However, it is not clear whether monounsaturated fatty acid...

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    pub_type: 杂志文章


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    更新日期:2014-09-01 00:00:00

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    journal_title:International journal of cardiology

    pub_type: 信件


    authors: Marra F,Galderisi M,Camera A,Rinaldi CR,Innelli P,Rotoli B,de Divitiis O

    更新日期:2007-01-18 00:00:00

  • Cardiac tamponade as presentation of systemic amyloidosis.

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    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Navarro JF,Rivera M,Ortuño J

    更新日期:1992-07-01 00:00:00

  • Capecitabine induced vasospastic angina.

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    pub_type: 杂志文章


    authors: Coughlin S,Das S,Lee J,Cooper J

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    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Fujita M,Asanuma H,Kim J,Liao Y,Hirata A,Tsukamoto O,Minamino T,Hori M,Goto M,Node K,Kitakaze M

    更新日期:2007-05-16 00:00:00

  • Interpretation of elevated high-sensitivity cardiac troponin I in elite soccer players previously infected by severe acute respiratory syndrome coronavirus 2.

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