Microvesicle protein levels are associated with increased risk for future vascular events and mortality in patients with clinically manifest vascular disease.


BACKGROUND AND OBJECTIVES:Microvesicles (MVs) are small membrane vesicles that are involved in atherotrombotic processes. In the present study, we evaluated the risk of MV protein levels on the occurrence of new vascular events in patients with clinically manifest vascular disease. METHODS:In this cohort study 1060 patients were prospectively followed for the occurrence of a new vascular event or death (median follow up 6.4 years, interquartile range 5.2-7.3 years). MVs were isolated from plasma and MV protein levels of Cystatin C, Serpin G1, Serpin F2 and CD14 were measured. Multivariable Cox proportional hazards models were used to estimate the risk for new vascular events, vascular mortality and all-cause mortality. During follow up 136 vascular events occurred, 65 vascular mortality and 114 all-cause mortality. RESULTS:An increase in 1 standard deviation (SD) of Cystatin C MV level was related to an increased risk for myocardial infarction (HR 1.49; 95%CI 1.20-1.86), vascular mortality (HR 1.48; 95%CI 1.17-1.86), vascular events (HR 1.27; 1.07-1.52) and all-cause mortality (HR 1.41; 95%CI 1.18-1.69). Serpin F2 MV levels were related to an increased risk for myocardial infarction (HR 1.22; 95%CI 1.00-1.51), vascular mortality (HR 1.25; 95%CI 1.00-1.56), and all-cause mortality (HR 1.22; 95% CI 1.03-1.45). CD14 MV levels were related to an increased risk for myocardial infarction (HR 1.55; 95%CI 1.27-1.91), vascular mortality (HR 1.37; 95%CI 1.10-1.70), vascular events (HR 1.32; 95%CI 1.12-1.55), all-cause mortality (HR 1.36; 95%CI 1.15-1.62) and occurrence of ischemic stroke (HR 1.32; 95%CI 1.00-1.74). CONCLUSIONS:Cystatin C, Serpin F2 and CD14 MV levels are related to an elevated risk for future vascular events and mortality in patients with clinically manifest vascular disease.


Int J Cardiol


Kanhai DA,Visseren FL,van der Graaf Y,Schoneveld AH,Catanzariti LM,Timmers L,Kappelle LJ,Uiterwaal CS,Lim SK,Sze SK,Pasterkamp G,de Kleijn DP,SMART Study Group.




Has Abstract


2013-10-03 00:00:00














  • Outcome of patients with post acute myocardial infarction ischemia hospitalized in intensive cardiac care units with and without on-site catheterization laboratories.

    abstract:BACKGROUND:This study addresses the impact of availability of on-site catheterization laboratories on the 1-year survival of patients with post-acute myocardial infarction ischemia (P-AMI-I), a high-risk subgroup of AMI patients. METHODS:A prospective 5 month national survey was conducted in 1996 in all operating inte...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Blondheim DS,Gottlieb S,Behar S,Marmor AT,Israeli Thrombolytic Survey Group.

    更新日期:2001-06-01 00:00:00

  • Supracristal ventricular septal defect in adults: Is it time for a paradigm shift?

    abstract:BACKGROUND:To determine the risk and predictors of progression of aortic regurgitation (AR) and other adverse events (AE) in adults with supracristal ventricular septal defect (VSD). METHODS:Retrospective observational study of 62 adults with supracristal VSD followed at the Mayo Clinic from 1994 to 2013. Freedom from...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Egbe AC,Poterucha JT,Dearani JA,Warnes CA

    更新日期:2015-11-01 00:00:00

  • Expression of Lmna-R225X nonsense mutation results in dilated cardiomyopathy and conduction disorders (DCM-CD) in mice: Impact of exercise training.

    abstract:AIMS:To recapitulate progressive human dilated cardiomyopathy (DCM) and heart block in the Lmna R225X mutant mice model and investigate the molecular basis of LMNA mutation induced cardiac conduction disorders (CD); To investigate the potential interventional impact of exercise endurance. METHODS AND RESULTS:A Lmna R2...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Cai ZJ,Lee YK,Lau YM,Ho JC,Lai WH,Wong NL,Huang D,Hai JJ,Ng KM,Tse HF,Siu CW

    更新日期:2020-01-01 00:00:00

  • Impact of race on morbidity and mortality in patients with congestive heart failure: a study of the multiracial population in Singapore.

    abstract:AIM:We assessed the impact of race on clinical outcome in the multiracial Singapore congestive heart failure (CHF) population. METHODS:668 CHF patients (Age 66+/-12 years, Ejection fraction 29+/-13%), consisting of Chinese (72%), Malays (17.1%) and Indians (10.9%) were prospectively followed up for 24+/-12 months. Pri...

    journal_title:International journal of cardiology

    pub_type: 信件


    authors: Lee R,Chan SP,Chan YH,Wong J,Lau D,Ng K

    更新日期:2009-05-29 00:00:00

  • Effect of free fatty acid inhibition on silent and symptomatic myocardial ischemia in diabetic patients with coronary artery disease.

    abstract:OBJECTIVE:Free fatty acid inhibition with trimetazidine (TMZ) improves myocardial metabolism and myocardial ischemia in patients with coronary artery disease (CAD). Because of its effect on myocardial glucose utilization TMZ may represent a therapeutic option in diabetic patients with CAD. Aim of the present study was ...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,随机对照试验


    authors: Marazzi G,Wajngarten M,Vitale C,Patrizi R,Pelliccia F,Gebara O,Pierri H,Ramires JA,Volterrani M,Fini M,Rosano GM

    更新日期:2007-08-09 00:00:00

  • Transient postoperative pericardial constriction in a child.

    abstract::Constrictive pericarditis has been defined classically as a progressive condition, characterized by pericardial fibrosis, with or without calcification, which results in chronic refractory congestive heart failure and for witch pericardiectomy is often required. In the last decades there have been reports describing a...

    journal_title:International journal of cardiology

    pub_type: 信件


    authors: Betrián Blasco P,Comas JG,Ferrer JC,Menduña QF,García BM,Ipiña FG

    更新日期:2009-01-09 00:00:00

  • Clinical significance of fecal occult blood screening in patients before percutaneous coronary intervention.

    abstract:BACKGROUND:The most common reason for premature discontinuation of dual anti-platelet therapy (DAPT) after coronary stenting is the manifestation of gastrointestinal bleeding. Before percutaneous coronary interventions (PCIs), we screened patients who tested positive for fecal occult blood (fecOB). METHODS AND RESULTS...

    journal_title:International journal of cardiology

    pub_type: 信件


    authors: Sueta D,Hokimoto S,Tayama S,Tsujita K,Sakamoto K,Yamamoto E,Tanaka T,Izumiya Y,Yamamuro M,Yamanaga K,Akasaka T,Tababa N,Arima Y,Kaikita K,Ogawa H

    更新日期:2015-03-01 00:00:00

  • Ambulatory electrical cardioversion of atrial fibrillation.

    abstract::Elective electrical cardioversion of atrial fibrillation is an effective and safe cardiac procedure in selected patients. It is most often performed during a short hospital stay or in an outpatient setting of a hospital. In a retrospective analysis, we report our experience on electrical cardioversions in private prac...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Franzen D,Brombach K,Möbius H

    更新日期:2006-03-08 00:00:00

  • Chronic kidney disease is associated with vascular smooth muscle dysfunction but not with endothelial dysfunction.

    abstract:BACKGROUNDS:Nitroglycerine-induced vasodilation (NID) is usually assessed as a control test for flow-mediated vasodilation (FMD). However, NID per se is impaired in patients with high cardiovascular risk. The purpose of this study was to investigate the associations of chronic kidney disease (CKD) with NID and FMD. ME...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Iwamoto Y,Maruhashi T,Kajikawa M,Oda N,Kishimoto S,Matsui S,Hashimoto H,Aibara Y,Yusoff FM,Hidaka T,Kihara Y,Chayama K,Noma K,Nakashima A,Goto C,Higashi Y

    更新日期:2018-03-01 00:00:00

  • Large animal model of acute right ventricular failure with functional tricuspid regurgitation.

    abstract:BACKGROUND:Functional tricuspid regurgitation (FTR) commonly arises secondary to conditions affecting the left heart and is associated with right ventricular dysfunction and tricuspid annular dilatation. We set out to establish an animal model of acute RV failure (RVF) with FTR resembling the clinical features. METHOD...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Malinowski M,Proudfoot AG,Eberhart L,Schubert H,Wodarek J,Langholz D,Rausch MK,Timek TA

    更新日期:2018-08-01 00:00:00

  • Neighborhood deprivation and warfarin, aspirin and statin prescription - A cohort study of men and women treated for atrial fibrillation in Swedish primary care.

    abstract:BACKGROUND:We aimed to study differences in the prescribing of warfarin, aspirin and statins to patients with atrial fibrillation (AF) in socio-economically diverse neighborhoods. We also aimed to explore the effects of neighborhood deprivation on the relationship between CHADS2 risk score and warfarin prescription. M...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Carlsson AC,Wändell P,Gasevic D,Sundquist J,Sundquist K

    更新日期:2015-01-01 00:00:00

  • Allopurinol, benzbromarone and risk of coronary heart disease in gout patients: A population-based study.

    abstract:BACKGROUND:The effect of gout on the risk of developing coronary artery disease (CAD) is uncertain. Some studies have found that gout is a risk factor for acute myocardial infarction. This study examined the changes in risk of CAD in gout patients taking allopurinol and/or benzbromarone, and analyzed the dose-response ...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,随机对照试验


    authors: Lin HC,Daimon M,Wang CH,Ho Y,Uang YS,Chiang SJ,Wang LH

    更新日期:2017-04-15 00:00:00

  • Facilitated percutaneous coronary intervention (PCI) in patients with acute ST-elevation myocardial infarction: comparison of prehospital tirofiban versus fibrinolysis before direct PCI.

    abstract:AIMS:Early start of treatment including coronary revascularization has been recognized as crucial variable in the outcome of acute ST-segment elevation myocardial infarction (STEMI). The lack of availability and the realisation that an optimum reperfusion strategy will need to incorporate mechanical reperfusion as part...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Möckel M,Bocksch W,Strohm S,Kühnle Y,Vollert J,Nibbe L,Dietz R

    更新日期:2005-08-18 00:00:00

  • Predicting procedure successful rate and 1-year patency after endovascular recanalization for chronic carotid artery occlusion by CT angiography.

    abstract:BACKGROUND:Proper patient selection criteria for treatment of carotid chronic total occlusion (CTO) are unclear. This study was designed to predict procedure successful rate and 1-year patency after carotid artery stenting (CAS) for carotid CTO using pre-procedural CTA. METHODS:Patients with CTO detected on CTA who un...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Lee CW,Lin YH,Liu HM,Wang YF,Chen YF,Wang JL

    更新日期:2016-10-15 00:00:00

  • Surgical therapy for drug-refractory ventricular tachycardia: role of additional aneurysmectomy or bypass grafting.

    abstract::To assess whether additional aneurysmectomy and/or bypass grafting influence prognosis we studied 97 patients with recurrent sustained monomorphic ventricular tachycardia after an old myocardial infarction. All patients underwent subendocardial resection due to drug-refractory ventricular tachycardia. There were 41 pa...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Trappe HJ,Klein H,Frank G,Wenzlaff P,Lichtlen PR

    更新日期:1992-03-01 00:00:00

  • Isolated interrupted aortic arch: in a 40-year-old adult.

    abstract::Interrupted aortic arch (IAA) is a scarce and generally lethal congenital malformation. Patients with complete IAA scarcely reach adult age without previous surgical intervention. In this case, we presented a 40-year-old isolated IAA case with hypertension and angina pectoris. IAA just distal to left subclavian artery...

    journal_title:International journal of cardiology

    pub_type: 信件


    authors: Gokce M,Kiriş A,Karakoç G,Kosucu P,Pulathan Z

    更新日期:2010-02-04 00:00:00

  • Variant form of tako-tsubo cardiomyopathy.

    abstract::We report a female case of variant form of tako-tsubo cardiomyopathy in which wall motion of the distal segment was preserved. In the current case, left ventriculography showed akinesia of the mid portion and normokinesia of the distal and basal portions of the left ventricular chamber. ST-segment elevation was obviou...

    journal_title:International journal of cardiology

    pub_type: 信件


    authors: Kurisu S,Inoue I,Kawagoe T,Ishihara M,Shimatani Y,Nakama Y,Ohkawa K,Maruhashi T,Kagawa E,Dai K,Aokage T

    更新日期:2007-07-10 00:00:00

  • White blood cell count and new-onset atrial fibrillation after cardiac surgery.

    abstract:BACKGROUND:Postoperative new-onset atrial fibrillation (PNAF) is the most common complication following cardiac surgery. The inflammatory response, as a potential underlying mechanism, has been extensively studied. In small studies, the white blood cell count (WBC) has been shown to be the only consistent inflammatory ...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Jacob KA,Buijsrogge MP,Frencken JF,Ten Berg MJ,Suyker WJ,van Dijk D,Dieleman JM

    更新日期:2017-02-01 00:00:00

  • Three decades later: The fate of the population of patients who underwent the Atriopulmonary Fontan procedure.

    abstract:OBJECTIVE:To review our experience of patients with an atrio-pulmonary Fontan circulation to determine their long-term outcomes. METHODS AND RESULTS:A retrospective analysis of long-term follow-up data using the Australia and New Zealand Fontan Registry was performed. There were 215 patients surviving hospital dischar...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,多中心研究


    authors: Poh CL,Zannino D,Weintraub RG,Winlaw DS,Grigg LE,Cordina R,Hornung T,Bullock A,Justo RN,Gentles TL,Verrall C,du Plessis K,Celermajer DS,d'Udekem Y

    更新日期:2017-03-15 00:00:00

  • Pulmonary congestion evaluated by lung ultrasound predicts decompensation in heart failure outpatients.

    abstract:BACKGROUND:Pulmonary congestion is the main cause of hospital admission among heart failure (HF) patients. Lung ultrasound (LUS) assessment of B-lines has been recently proposed as a reliable and easy tool for evaluating pulmonary congestion. OBJECTIVE:To determine the prognostic value of LUS in predicting adverse eve...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Miglioranza MH,Picano E,Badano LP,Sant'Anna R,Rover M,Zaffaroni F,Sicari R,Kalil RK,Leiria TL,Gargani L

    更新日期:2017-08-01 00:00:00

  • Acute hemodynamic responses to adenosine and iloprost in patients with congenital heart defects and severe pulmonary arterial hypertension.

    abstract:BACKGROUND:Detection of pulmonary vasoreactivity is important for the evaluation of patient with pulmonary arterial hypertension (PAH). The present study aimed to investigate the acute hemodynamic responses to adenosine and iloprost in patients with congenital heart defects (CHDs) and severe PAH. PATIENTS AND METHODS:...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,随机对照试验


    authors: Zhang DZ,Zhu XY,Meng J,Xue HM,Sheng XT,Han XM,Cui CS,Wang QG,Zhang P

    更新日期:2011-03-17 00:00:00

  • Comparison of results and complications of surgical and Amplatzer device closure of perimembranous ventricular septal defects.

    abstract:BACKGROUND:Surgery for perimembranous ventricular septal defects (VSD) is widely accepted procedure with minimal operative mortality. Recent publications have reported the feasible, safe, and effective with the new Amplatzer VSD occluder. This study was done to compare the effectiveness, cost, and complications of both...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Xunmin C,Shisen J,Jianbin G,Haidong W,Lijun W

    更新日期:2007-08-09 00:00:00

  • Prognostic impact of global left ventricular hemodynamic afterload in severe aortic stenosis with preserved ejection fraction.

    abstract:INTRODUCTION:Global left ventricular (LV) afterload as assessed by valvulo-arterial impedance (Zva), may be an independent predictor of mortality in patients with severe aortic stenosis (AS) and preserved LV ejection fraction (LVEF). However, its quantification using echocardiography may be subject to error measurement...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Magne J,Mohty D,Boulogne C,Deltreuil M,Cassat C,Echahidi N,Laskar M,Lacroix P,Virot P,Aboyans V

    更新日期:2015-02-01 00:00:00

  • Valsalva sinus pseudoaneurysm causes acute myocardial infarction and stroke simultaneously.

    abstract::Spontaneous Valsalva sinus pseudoaneurysm is a rare and highly lethal condition. Below we present a clinical case of a young woman with spontaneous Valsalva sinus pseudoaneurysm diagnosed presenting with acute myocardial infarction (AMI) and ischemic stroke. ...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Núñez J,Fácila L,Sanchis J,Bodi V,Llacer A,Martinez A,Bertomeu V,Chorro J

    更新日期:2004-11-01 00:00:00

  • Practice variation in the re-initiation of dofetilide: An observational study.

    abstract:BACKGROUND:Dofetilide is a class III antiarrhythmic drug that has been reported to be safe and efficacious in the treatment of atrial dysrhythmias with a known initial risk of QT prolongation and torsades de pointes (TdP). As a result, the Federal Drug Administration (FDA) mandated in-hospital dofetilide initiation and...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Turagam MK,Afzal MR,Reddy M,Pillarisetti J,Lavu M,Atkins D,Jeffrey C,Christensen K,Pimentel R,Dendi R,Vacek J,Hurwitz J,Di Biase L,Natale A,Lakkireddy D

    更新日期:2017-06-01 00:00:00

  • Impairment factors for evaluating the patency of drug-eluting stents and bare metal stents in coronary arteries by 64-slice computed tomography versus conventional coronary angiography.

    abstract:PURPOSE:To identify, using logistic regression models, factors impairing evaluation of patency of drug-eluting stents (DES) and bare metal stents (BMS) in coronary arteries by 64-slice MSCT versus conventional coronary angiography (CAG). MATERIALS AND METHODS:We evaluated 75 stents (16 DES and 59 BMS; 57 in males) imp...

    journal_title:International journal of cardiology

    pub_type: 临床试验,杂志文章


    authors: Nakamura K,Funabashi N,Uehara M,Suzuki K,Terao M,Okubo K,Mita Y,Maeda F,Komuro I

    更新日期:2008-11-28 00:00:00

  • False tendons may be associated with the genesis of J-waves: prospective study in young healthy male.

    abstract:BACKGROUND:Recent studies showed that J-waves are associated with vulnerability to ventricular fibrillation. Recently we reported the association between false tendons (FTs) and J-waves in a retrospective study. METHODS AND RESULTS:We prospectively studied 50 young healthy men (mean age 24.6±2.7 years). FTs were detec...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Nakagawa M,Ezaki K,Miyazaki H,Ebata Y,Shinohara T,Teshima Y,Yufu K,Takahashi N,Saikawa T

    更新日期:2014-03-15 00:00:00

  • Effectiveness of a management program for outpatient clinic or remote titration of beta-blockers in CRT patients: The RESTORE study.

    abstract:BACKGROUND:Many patients fail to receive β-blockers before cardiac resynchronization therapy defibrillator (CRT-D) implantation, or receive them at a suboptimal dose, and require optimization after implantation. We assessed the effectiveness of a structured program for β-blocker titration in CRT-D patients followed up ...

    journal_title:International journal of cardiology

    pub_type: 杂志文章,多中心研究


    authors: D'Onofrio A,Palmisano P,Rapacciuolo A,Ammendola E,Calò L,Ruocco A,Bianchi V,Maresca F,Del Giorno G,Martino A,Mauro C,Campari M,Valsecchi S,Accogli M

    更新日期:2017-06-01 00:00:00

  • Critical potential of early cardiac surgery for infective endocarditis with cardio-embolic strokes.

    abstract:BACKGROUND:Early cardiac surgery may have a trade-off between stabilized hemodynamics with controlled infection and a risk of peri-operative death in patients with infective endocarditis (IE) complicated with cardio-embolic strokes. METHODS:We retrospectively studied clinical characteristics and outcomes in 68 consecu...

    journal_title:International journal of cardiology

    pub_type: 杂志文章


    authors: Suzuki M,Takanashi S,Ohshima Y,Nagatomo Y,Seki A,Takamisawa I,Tobaru T,Naito K,Kin H,Umemura J,Takayama M,Sumiyoshi T,Tomoike H

    更新日期:2017-01-15 00:00:00

  • Invasive treatment performed for acute myocardial infarction in a patient with immune thrombocytopenic purpura.

    abstract::Acute myocardial infarction (AMI) is infrequent in patients with idiopathic thrombocytopenic purpura (ITP) so the best treatment is not well known. The next case shows a 37-year-old man with chronic ITP who suffered an anterior AMI, the platelet count at admission was 39,000 microL. He was treated successfully with pr...

    journal_title:International journal of cardiology

    pub_type: 信件


    authors: Gracia MC,Cebollero IC,Lezcano JS,Osuna GG,Miguel JA,Peralta LP

    更新日期:2008-07-21 00:00:00