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Antiproliferative potency of novel benzofuran-2-carboxamides on tumour cell lines: cell death mechanisms and determination of crystal structure.

Abstract：

:In this manuscript the synthesis and biological activity of novel heterocyclic derivatives of benzofuran-2-carboxamides 3a-j and 6a-f is presented. Biological evaluation in vitro revealed that only few compounds exerted concentration-depended antiproliferative effects on tumour cell lines at micromolar concentrations. In particular, 2-imidazolynyl substituted compound 6f showed selectivity on SK-BR-3 cell line while 2-N-acetamidopyridyl substituted 3h and 2-imidazolynyl substituted amide 3i showed selective concentration-dependent antiproliferative effects on SW620 cell line. Compounds 3h and 6f induced apoptosis while compound 3i acted through a cell death mechanism other than apoptosis.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Hranjec M,Sović I,Ratkaj I,Pavlović G,Ilić N,Valjalo L,Pavelić K,Kraljević Pavelić S,Karminski-Zamola G

doi

10.1016/j.ejmech.2012.11.009

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

111-9

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(12)00678-2

journal_volume

59

pub_type

杂志文章

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