Abstract:
:To demonstrate ultrasound contrast agents to be important potentiators of high-intensity focused ultrasound (HIFU), we prospectively assessed the effectiveness of HIFU combined with nanoscale ultrasound contrast agents for the treatment of breast VX2 tumors in rabbits. We found that the change of grayscale value in the target area in the HIFU+nanobubble group was significantly higher than that in the HIFU+phosphate-buffered saline (PBS) group after irradiation (P<.01). The size of coagulation necrosis was also significantly larger in the HIFU+nanobubble group when compared to that in the HIFU+PBS group (P<.001). In conclusion, our study suggested that adding nanoscale ultrasound contrast agents may improve the treatment efficacy of HIFU for breast VX2 tumors in rabbits.
journal_name
Clin Imagingjournal_title
Clinical imagingauthors
Wang D,Li L,Min J,Guo Y,Guo H,Gao J,Yang K,Zou Jdoi
10.1016/j.clinimag.2012.01.042subject
Has Abstractpub_date
2012-11-01 00:00:00pages
717-23issue
6eissn
0899-7071issn
1873-4499pii
S0899-7071(12)00062-9journal_volume
36pub_type
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