Abstract：
PURPOSE:To investigate differences in clinical features, MRI findings and tumor biomarker characteristics in screen-detected (SCD) and non-screendetected (NSCD) cancers. MATERIAL AND METHODS:A total of 62 women (mean age, 48.4 years; range, 33-68 years) with biopsy confirmed breast cancer who underwent preoperative breast MRI were retrospectively evaluated by two expert radiologists. The women were divided into two groups according to the mode of cancer detection (Group A: screen- detected, Group B: non-screen/symptomatic cancer) and clinical, histopathological, MRI characteristics and biomarker features in each group were evaluated. RESULTS:NSCD tumors had significantly greater size (3.5 cm vs. 2.1 cm) and Ki-67 expression (68.4% vs. 41.7%) in comparison to SCD cancers. NSCD cancers were less likely to have strongly positive progesterone receptors (Pr) and more likely to have Ki-67 > 15% or positive nodal status (47.4% vs. 8.3%). Increased breast density (ACR C and D: 78.9% vs. 50%ACR A and B) and intense background parenchymal enhancement (BPE, moderate/marked: 42.1% vs. 8.3% minimal/mild) were significantly more frequent in NSCD cases. CONCLUSION:NSCD cancers had higher prevalence of poor prognostic characteristics in comparison to SCD tumors, including larger tumor size, higher Ki-67 index, and positive nodes. Increased fibroglandular tissue and intense BPE were both strongly associated with NSCD cancers, supporting their use as potential MR biomarkers in breast cancer risk models.
journal_name
Clin Imagingjournal_title
Clinical imagingauthors
Panourgias E,Bourgioti C,Koureas A,Koutoulidis V,Metaxas G,Moulopoulos LAdoi
10.1016/j.clinimag.2018.08.011subject
Has Abstractpub_date
2018-01-01 00:00:00pages
350-355eissn
0899-7071issn
1873-4499pii
S0899-7071(18)30232-8journal_volume
52pub_type
杂志文章相关文献
CLINICAL IMAGING文献大全abstract：:To compare the specific information provided by ultrasound (US) and galactography and to appreciate the clinical applicability of US as a primary diagnostic method for breast tumors associated with nipple discharge, a comparative study of each method in 15 patients with ductal tumors of the breast was performed. To ev...
journal_title：Clinical imaging
pub_type： 杂志文章
doi：10.1016/0899-7071(93)00007-l
更新日期：1995-07-01 00:00:00
abstract：PURPOSE:It is very important in the management of patients with differentiated thyroid cancer (DTC) to precisely localize the foci of I-131 uptake, but it is difficult because of a lack of anatomic landmarks. The purpose of this study was to investigate the added value of I-131 single-photon emission computed tomograph...
journal_title：Clinical imaging
pub_type： 杂志文章
doi：10.1016/j.clinimag.2008.06.024
更新日期：2009-01-01 00:00:00
abstract：:Thirty patients with prostate or bladder cancer underwent CT and MRI for nodal staging. CT detected 189 nodes, and MRI detected 271 nodes. This difference was statistically significant in the external iliac (CT/MRI=73/87 nodes), obturator (CT/MRI=48/75 nodes), and internal iliac (CT/MRI=24/46 nodes) nodal chains. Base...
journal_title：Clinical imaging
pub_type： 杂志文章
doi：10.1016/j.clinimag.2009.07.004
更新日期：2010-09-01 00:00:00
abstract：:A 29-year-old woman suffered uncontrollable massive hemorrhage from a deep vaginal laceration following spontaneous vaginal delivery. Pelvic angiography revealed extravasation from a branch of the right pudendal artery. Transcatheter arterial embolization was successfully performed and quickly achieved hemostasis. Whe...
journal_title：Clinical imaging
pub_type： 杂志文章
doi：10.1016/s0899-7071(01)00235-2
更新日期：2000-11-01 00:00:00
abstract：:The radiographic appearance of intestinal edema, including colonic edema, has been well described in the literature. Severe wall circumferential thickening can occur within the colon in a number of conditions. This includes edema secondary to colitis, allergy, ischemia, and infiltrative neoplastic processes. Edema may...
journal_title：Clinical imaging
pub_type： 杂志文章
doi：10.1016/0899-7071(94)90137-6
更新日期：1994-01-01 00:00:00
abstract：BACKGROUND:There are two graft materials for endovascular repair of aortic diseases, i.e., polyester and expanded polytetrafluoroethylene (ePTFE). The latest reports have suggested that there is graft-specific difference in outcomes. The purpose of this article was to evaluate the difference in terms of aneurysm shrink...
journal_title：Clinical imaging
pub_type： 杂志文章
doi：10.1016/j.clinimag.2005.07.032
更新日期：2006-01-01 00:00:00
abstract：:Inferior lumbar (Petit's) hernia is an uncommon condition resulting from a defect in the posterior abdominal wall. Such hernias may be difficult to diagnose on the basis of physical signs and symptoms. A case of unsuspected inferior lumbar hernia clearly demonstrated by computed tomography (CT) is presented. Computed ...
journal_title：Clinical imaging
pub_type： 杂志文章
doi：10.1016/0899-7071(89)90102-2
更新日期：1989-06-01 00:00:00
abstract：OBJECTIVE:Assess the image quality of ECG-triggered High-Pitch Dual-Source CTA for the evaluation of native coronaries in children. MATERIALS AND METHODS:Between August 2014 and September 2017, 45 children with morphologically normal cardiac chambers had cardiac prospective ECG-triggered High-Pitch Dual-Source CTA. Tw...
journal_title：Clinical imaging
pub_type： 杂志文章
doi：10.1016/j.clinimag.2018.08.013
更新日期：2018-01-01 00:00:00
abstract：:Idiopathic necrosis of the second metatarsal head is quite unusual in adults. We present a rare case of idiopathic osteonecrosis of the second metatarsal head in an adult via magnetic resonance imaging, which enabled an early diagnosis of the necrosis before osteochondral deformity could develop. This case is notewort...
journal_title：Clinical imaging
pub_type： 杂志文章
doi：10.1016/j.clinimag.2007.03.008
更新日期：2007-11-01 00:00:00
abstract：:von Hippel-Lindau (VHL) disease is an unusual inherited chromosomal dominant disease characterized by CNS hemangioblastomas and visceral neoplasms. Multiple abnormalities may involve the abdomen including pathology in the liver, pancreas, kidneys, and adrenal glands. The present case report describes a patient with re...
journal_title：Clinical imaging
pub_type： 杂志文章
doi：10.1016/0899-7071(95)00066-6
更新日期：1997-01-01 00:00:00
abstract：:Three children with tracheomegaly were studied by CT scan at The Children's Hospital of Philadelphia. Normal age-related tracheal dimensions were obtained from a study by Griscom (1). Tracheomegaly was defined as tracheal dimensions greater than 2 SD above normal. In two of our patients, tracheomegaly was associated w...
journal_title：Clinical imaging
pub_type： 杂志文章,评审
doi：10.1016/0899-7071(89)90131-9
更新日期：1989-03-01 00:00:00
abstract：:An angioleiomyoma adjacent to the sciatic nerve was responsible for an 11-year history of pain and dysfunction in the sciatic nerve distribution, which required numerous therapeutic procedures and intermittent use of narcotic analgesics. Diagnosis was finally made when results of a sciatic nerve block suggested possib...
journal_title：Clinical imaging
pub_type： 杂志文章
doi：10.1016/0899-7071(93)90065-u
更新日期：1993-10-01 00:00:00
abstract：:We present the CT findings of a transient colocolic intussusception, related to an underlying colonic tumor, but remote from it. The resolving nature of intussusception was clearly demonstrated on delayed images and may explain the characteristic chronic clinical symptoms of intussusception in adult. ...
journal_title：Clinical imaging
pub_type： 杂志文章,评审
doi：10.1016/s0899-7071(00)00154-6
更新日期：2000-01-01 00:00:00
abstract：:We report a case in which computed tomography (CT) demonstrated gas within a thrombus in the superior vena cava in a patient with fever of unknown origin (FUO), indicating that the thrombus was infected. This CT finding is important to recognize, as it affects subsequent therapy. ...
journal_title：Clinical imaging
pub_type： 杂志文章
doi：10.1016/s0899-7071(97)00077-6
更新日期：1998-03-01 00:00:00
abstract：:Diffusion-weighted imaging and apparent diffusion coefficient (ADC) of 36 breast lesions previously categorized as 4 according to the Breast Imaging Reporting and Data System (BI-RADS) were prospectively studied. The pathological results were 21 benign lesions and 15 malignant. The ADC of malignant lesions was signifi...
journal_title：Clinical imaging
pub_type： 杂志文章
doi：10.1016/j.clinimag.2014.09.015
更新日期：2015-01-01 00:00:00
abstract：:Liver volume measurement has many clinical and research uses. The purpose of the present study is to evaluate experimentally the accuracy and reproducibility of spiral computed tomography (CT) in measuring liver volume. To determine the accuracy of spiral CT system, nine fresh (non-formalin-fixed) sheep livers were sc...
journal_title：Clinical imaging
pub_type： 杂志文章
doi：10.1016/s0899-7071(01)00376-x
更新日期：2002-03-01 00:00:00
abstract：:Venous aneurysms rarely occur in the visceral veins. We report two extremely rare cases of venous aneurysms, one of the ovarian vein and the other one of the renal vein. The aneurysms were depicted on grayscale and color Doppler ultrasonography as anechoic saccular structures with compressibility and blood flow. Pulse...
journal_title：Clinical imaging
pub_type： 杂志文章
doi：10.1016/j.clinimag.2016.01.004
更新日期：2016-07-01 00:00:00
abstract：:Malignant peripheral nerve sheath tumor (MPNST) is a relatively rare soft tissue malignant tumor. Most of reports currently are pathological articles and clinical case reports and most of them are MPNST in the thorax, abdomen or extremities. Imaging report of spinal MPNST is very rare, and MPNST is easy to be misdiagn...
journal_title：Clinical imaging
pub_type： 杂志文章
doi：10.1016/j.clinimag.2011.08.015
更新日期：2012-05-01 00:00:00
abstract：BACKGROUND:Conventional breast magnetic resonance imaging (MRI), including dynamic contrast-enhanced MR mammography, may lead to ambiguous diagnosis and unnecessary biopsies. PURPOSE:To investigate the contribution of quantitative diffusion tensor imaging (DTI) in the discrimination between benign and malignant breast...
journal_title：Clinical imaging
pub_type： 杂志文章
doi：10.1016/j.clinimag.2018.10.002
更新日期：2019-01-01 00:00:00
abstract：:The benefits of early diagnosis and treatment of breast cancer are well established. Thoracic CT which is performed with increased frequency for lung cancer screening can diagnose breast cancer earlier then might be possible clinically. The imaged and radiation exposed breasts must be included in their entirety on ima...
journal_title：Clinical imaging
pub_type： 社论
doi：10.1016/j.clinimag.2018.04.006
更新日期：2018-01-01 00:00:00
abstract：:Magnetic resonance (MR) angiographic studies of 14 patients with intracranial aneurysms (AN) were analyzed retrospectively as compared with contrast angiographic studies. Eighteen of 19 (95%) lesions were detected, and the relation between AN and their parent vessels was precisely assessed. The diameter of the smalles...
journal_title：Clinical imaging
pub_type： 杂志文章
doi：10.1016/0899-7071(94)90044-2
更新日期：1994-04-01 00:00:00
abstract：:Brucellosis is a zoonosis of worldwide distribution presenting with a wide clinical spectrum. Brucellosis can involve any organ or system. The axial skeleton is the most common site of involvement with a frequency ranging from 2% to 53%. Multiple-level spinal involvements are rare. This report describes the first case...
journal_title：Clinical imaging
pub_type： 杂志文章
doi：10.1016/j.clinimag.2005.10.006
更新日期：2006-05-01 00:00:00
abstract：OBJECTIVES:To review the imaging of patients with Genetically-Mediated Pancreatitis (GMP), identify common imaging findings in this cohort and assess phenotypical characteristics of specific genotypes. MATERIALS AND METHODS:Retrospective review of the databases of the Irish National Surgical Centre for Pancreatic Canc...
journal_title：Clinical imaging
pub_type： 杂志文章
doi：10.1016/j.clinimag.2020.04.005
更新日期：2020-09-01 00:00:00
abstract：:The diagnosis of a large solitary lytic skull vault lesion in adults is a challenge due to variable aggressiveness and overlapping features. The purpose of this article is to demonstrate the use of an imaging approach to narrow the differential diagnosis when a large solitary lytic skull vault lesion is encountered. T...
journal_title：Clinical imaging
pub_type： 杂志文章,评审
doi：10.1016/j.clinimag.2019.10.011
更新日期：2020-02-01 00:00:00
abstract：AIMS:To evaluate the diagnostic performance of computed tomography combined with ultrasound (CT/US) in metastatic central lymph nodes (CLNs) compared with US in patients with papillary thyroid cancer (PTC). MATERIAL AND METHODS:Six-hundred patients with surgically proven PTC who underwent both US and CT examination be...
journal_title：Clinical imaging
pub_type： 杂志文章
doi：10.1016/j.clinimag.2021.01.008
更新日期：2021-01-12 00:00:00
abstract：PURPOSE:Most living related donor (LRD) kidneys are harvested laparoscopically. Renal vascular anatomy helps determine donor suitability for laparoscopic nephrectomy. Computed tomography angiography (CTA) is the current gold standard for preoperative imaging; magnetic resonance angiography (MRA) offers advantages inclu...
journal_title：Clinical imaging
pub_type： 临床试验,杂志文章
doi：10.1016/j.clinimag.2016.01.010
更新日期：2016-05-01 00:00:00
abstract：PURPOSE:The aim of this study was to address the efficacy of 2-[F-18]-Fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) in the staging of non-small cell lung cancer (NSCLC) and in prognostic prediction in patients with NSCLC. METHODS:Forty-four patients (26 males, 18 females) were analyzed. RESULTS:Accu...
journal_title：Clinical imaging
pub_type： 杂志文章
doi：10.1016/j.clinimag.2008.06.032
更新日期：2009-03-01 00:00:00
abstract：OBJECTIVE:The purpose of our article is to review the magnetic resonance imaging (MRI) features of nongynaecologic cystic lesions of the pelvis. CONCLUSION:The rising use of MRI for pelvic exploration will result in an increase in incidental detection of pelvic cystic cysts. Pelvic cysts of non gynecologic origin are ...
journal_title：Clinical imaging
pub_type： 杂志文章,评审
doi：10.1016/j.clinimag.2012.04.023
更新日期：2013-03-01 00:00:00
abstract：:The study was initiated to characterize and better understand the natural characteristics of axillary lymph nodes (LNs) apparent on dynamic breast magnetic resonance imaging (MRI). The most important finding in 71 subjects that included healthy women was that 41% showed strong enhanced axillary LNs. The dynamic curves...
journal_title：Clinical imaging
pub_type： 杂志文章
doi：10.1016/j.clinimag.2011.12.022
更新日期：2012-07-01 00:00:00
abstract：:Various tumors can occur in the scrotum. Among them, angiomyofibroblastoma-like tumors are very rare mesenchymal tumors. We report a case of an angiomyofibroblastoma-like tumor that arose in the right half of the scrotum in a 72-year-old man. It is difficult to separate angiomyofibroblastoma-like tumors from other mal...
journal_title：Clinical imaging
pub_type： 杂志文章
doi：10.1016/j.clinimag.2011.11.026
更新日期：2012-09-01 00:00:00
