Benefit-risk balance of reoperation for persistent medullary thyroid cancer.

Abstract:

OBJECTIVE:This investigation aimed at exploring the prospects of a cure for persistent medullary thyroid cancer (MTC) stratified by basal calcitonin levels before reoperation and the number of lymph node metastases previously removed at outside facilities. BACKGROUND:There is no evidence-based information supporting the balance of surgical benefit and risk in persistent MTC. METHODS:This retrospective study of 334 patients with persistent MTC referred to a tertiary surgical center, who were compared with 367 patients with previously untreated MTC referred to that institution during the same time period, evaluated biochemical cure rates after systematic lymph node dissection. RESULTS:The relationship between the incremental serum calcitonin level before reoperation and the number of lymph node metastases at reoperation and biochemical cure was strong after previous removal of 0 (r = 0.74 and 77%-0%) and 1 to 5 lymph node metastases (r = 0.61 and 60%-0%) elsewhere. It disappeared once more than 5 lymph node metastases had been cleared at other hospitals (nonsignificant and 5%). When serum calcitonin levels were 1000 pg/mL or lower before reoperation, biochemical cure rates were 44% (59 of 133 patients) and 18% (12 of 65 patients) after previous removal of 0 and 1 to 5 lymph node metastases, respectively. These rates plummeted to 5% (2 of 43 patients) after a previous clearance of more than 5 lymph node metastases. When serum calcitonin levels exceeded 1000 pg/mL before reoperation, a biochemical cure was exceptional (1%; 1 of 76 patients). CONCLUSIONS:With serum calcitonin levels of 1000 pg/mL or lower before reoperation and the previous removal of 5 or fewer lymph node metastases, systematic lymph node dissection seems worthwhile for persistent MTC. These findings will need to be validated in independent series before being adopted more widely as a new standard of care.

journal_name

Ann Surg

journal_title

Annals of surgery

authors

Machens A,Dralle H

doi

10.1097/SLA.0b013e31826bc239

subject

Has Abstract

pub_date

2013-04-01 00:00:00

pages

751-7

issue

4

eissn

0003-4932

issn

1528-1140

journal_volume

257

pub_type

杂志文章
  • A lethally irradiated allogeneic granulocyte-macrophage colony stimulating factor-secreting tumor vaccine for pancreatic adenocarcinoma. A Phase II trial of safety, efficacy, and immune activation.

    abstract:PURPOSE:Surgical resection provides the only possibility of cure for pancreas cancer. A standard adjuvant approach has not been established. We tested the safety and efficacy of a granulocyte-macrophage colony-stimulating factor (GM-CSF)-based immunotherapy administered in patients with resected pancreatic adenocarcino...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e3181fd271c

    authors: Lutz E,Yeo CJ,Lillemoe KD,Biedrzycki B,Kobrin B,Herman J,Sugar E,Piantadosi S,Cameron JL,Solt S,Onners B,Tartakovsky I,Choi M,Sharma R,Illei PB,Hruban RH,Abrams RA,Le D,Jaffee E,Laheru D

    更新日期:2011-02-01 00:00:00

  • Totally laparoscopic Roux-en-Y duct-to-mucosa pancreaticojejunostomy after middle pancreatectomy: a consecutive nine-case series at a single institution.

    abstract:OBJECTIVE:To present the results of a series of laparoscopic middle pancreatectomies with roux-en-Y duct-to-mucosa pancreaticojejunostomy. SUMMARY OF BACKGROUND DATA:Middle pancreatectomy makes it possible to preserve pancreatic parenchyma in the resection of lesions that traditionally have been treated by distal sple...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e3181724e4a

    authors: Rotellar F,Pardo F,Montiel C,Benito A,Regueira FM,Poveda I,Martí-Cruchaga P,Cienfuegos JA

    更新日期:2008-06-01 00:00:00

  • Experimental comparison of the thrombogenicity of fibrin and PTFE flow surfaces.

    abstract::Two types of 4 mm ID prostheses were studied in the carotid arteries of the dog. These were noncrimped polypropylene-supported filamentous velour knitted Dacron (PPSFV) and expanded polytetrafluoroethylene (e-PTFE, Gore-Tex). Thrombus-"Free" Surface TFS) areas and patency rates were determined at the end of the implan...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198003000-00016

    authors: Kenny DA,Berger K,Walker MW,Robel SB,Boguslavsky L,Ray LI,Lischko MM,Sauvage LR

    更新日期:1980-03-01 00:00:00

  • Higher Recurrence Rate After Endoscopic Totally Extraperitoneal (TEP) Inguinal Hernia Repair With Ultrapro Lightweight Mesh: 5-Year Results of a Randomized Controlled Trial (TULP-trial).

    abstract:OBJECTIVE:The aim of this study was to determine inguinal hernia recurrence rates 5 years after endoscopic totally extraperitoneal (TEP) inguinal hernia repair when either lightweight or heavyweight mesh was used. BACKGROUND:Recurrence is an important complication of inguinal hernia surgery. Higher recurrence rates of...

    journal_title:Annals of surgery

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/SLA.0000000000002649

    authors: Roos MM,Bakker WJ,Schouten N,Voorbrood CEH,Clevers GJ,Verleisdonk EJ,Davids PH,Burgmans JP

    更新日期:2018-08-01 00:00:00

  • Catecholamines: mediator of the hypermetabolic response to thermal injury.

    abstract::Hypermetabolism characterizes the metabolic response to thermal injury and the extent of energy production is positively related to the rate of urinary catecholamine excretion. Alpha and beta adrenergic blockade decreased metabolism from 69.6 +/- 5.3 Kcal/m(2)/hr to 57.4 +/- 5.2 (p < 0.01), and infusion of 6 microgm e...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197410000-00031

    authors: Wilmore DW,Long JM,Mason AD Jr,Skreen RW,Pruitt BA Jr

    更新日期:1974-10-01 00:00:00

  • Immune RNA therapy for renal cell carcinoma: survival and immunologic monitoring.

    abstract::Twenty patients with metastatic renal cell carcinoma and nine patients with minimal residual disease (MRD) but at high risk for recurrence following nephrectomy received weekly four milligram intradermal injections of purified RNA extracted from lymphoid organs of sheep immunized with human renal cell carcinoma. Eight...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197710000-00007

    authors: Ramming KP,deKernion JB

    更新日期:1977-10-01 00:00:00

  • Lymphedema after complete axillary node dissection for melanoma: assessment using a new, objective definition.

    abstract:OBJECTIVES:The objectives of this study were to define appropriate criteria for assessing the presence of lymphedema, and to report the prevalence and risk factors for development of upper limb lymphedema after level I-III axillary dissection for melanoma. SUMMARY BACKGROUND DATA:The lack of a consistent and reliable ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/01.sla.0000143271.32568.2b

    authors: Starritt EC,Joseph D,McKinnon JG,Lo SK,de Wilt JH,Thompson JF

    更新日期:2004-11-01 00:00:00

  • Experience with mycophenolate mofetil (RS61443) in renal transplantation at a single center.

    abstract:OBJECTIVE:Mycophenolate mofetil (MM) is a new immunosuppressive agent that reversibly inhibits guanine nucleotide synthesis and DNA replication. Its activity is highly selective for T and B lymphocytes. Two open-label multicenter trials of MM in renal transplantation have been performed. This report summarizes the resu...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1097/00000658-199305010-00007

    authors: Deierhoi MH,Kauffman RS,Hudson SL,Barber WH,Curtis JJ,Julian BA,Gaston RS,Laskow DA,Diethelm AG

    更新日期:1993-05-01 00:00:00

  • Clinical experience with the use of a valve-bearing conduit to construct a second left ventricular outflow tract in cases of unresectable intra-ventricular obstruction.

    abstract::Two patients, ages 7 and 17, with unresectable obstructions within the left ventricular cavity, have been managed by interposing a conduit bearing a porcine aortic valve between the apex of the left ventricle and the infra-renal abdominal aorta. The younger child had idiopathic hypertrophic subaortic stenosis (IHSS) r...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197609000-00009

    authors: Dembitsky WP,Weldon CS

    更新日期:1976-09-01 00:00:00

  • The 30-day versus in-hospital and 90-day mortality after esophagectomy as indicators for quality of care.

    abstract:OBJECTIVE:To describe causes of death in the first year after esophagectomy and determine the time frame that should be used for measurement of quality of surgery. A case-mix adjustment model was developed for the comparison between hospitals. BACKGROUND:The time period in which postoperative mortality should be measu...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000000482

    authors: Talsma AK,Lingsma HF,Steyerberg EW,Wijnhoven BP,Van Lanschot JJ

    更新日期:2014-08-01 00:00:00

  • Registration rates, adequacy of registration, and a comparison of registered and published primary outcomes in randomized controlled trials published in surgery journals.

    abstract:OBJECTIVE:To determine the proportion of registered trials published in the surgical literature, to compare, in registered trials, the primary outcomes registered with those published and to determine whether outcome-reporting bias favored significant primary outcomes. BACKGROUND:Trial protocol registration before pat...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e318299d00b

    authors: Killeen S,Sourallous P,Hunter IA,Hartley JE,Grady HL

    更新日期:2014-01-01 00:00:00

  • A single-arm, nonrandomized phase II trial of neoadjuvant gemcitabine and oxaliplatin in patients with resectable pancreas adenocarcinoma.

    abstract:BACKGROUND:The role for neoadjuvant systemic therapy in resectable pancreas adenocarcinoma remains undefined. OBJECTIVE:We evaluated the efficacy of gemcitabine and oxaliplatin administered as preoperative therapy in patients with resectable pancreas adenocarcinoma. METHODS:Eligible patients were screened using compu...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章

    doi:10.1097/SLA.0000000000000251

    authors: OʼReilly EM,Perelshteyn A,Jarnagin WR,Schattner M,Gerdes H,Capanu M,Tang LH,LaValle J,Winston C,DeMatteo RP,DʼAngelica M,Kurtz RC,Abou-Alfa GK,Klimstra DS,Lowery MA,Brennan MF,Coit DG,Reidy DL,Kingham TP,Allen PJ

    更新日期:2014-07-01 00:00:00

  • Predictive factors for postoperative pulmonary complications and mortality after esophagectomy for cancer.

    abstract:OBJECTIVE:This study aimed at: (1) documenting the evolution of surgical results of esophagectomy in a high-volume center, (2) identifying predictive factors of pulmonary complications and mortality, and (3) examining whether preoperative chemoradiation therapy would complicate postoperative recovery. SUMMARY BACKGROU...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/01.sla.0000143123.24556.1c

    authors: Law S,Wong KH,Kwok KF,Chu KM,Wong J

    更新日期:2004-11-01 00:00:00

  • Surgical aspects of sclerosing cholangitis. Results in 178 patients.

    abstract::Of 178 patients with sclerosing cholangitis treated since 1950, 88 patients had associated inflammatory bowel disease, 72 had no such history, and 18 had iatrogenic injury or stone disease. A total of 233 biliary operations were performed, with a 75% rate of temporary improvement after initial operation. Subsequent op...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199010000-00017

    authors: Martin FM,Rossi RL,Nugent FW,Scholz FJ,Jenkins RL,Lewis WD,Gagner M,Foley E,Braasch JW

    更新日期:1990-10-01 00:00:00

  • A 4-tier Protocolized Radiological Classification System for Leaks Following Sleeve Gastrectomy.

    abstract:OBJECTIVES:To develop and validate a classification of sleeve gastrectomy leaks able to reliably predict outcomes, from protocolized computed tomography (CT) findings and readily available variables. SUMMARY OF BACKGROUND DATA:Leaks post sleeve gastrectomy remain morbid and resource-consuming. Incidence, treatments, a...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000003984

    authors: Johari Y,Catchlove W,Tse M,Shaw K,Paul E,Chen R,Loh D,Packiyanathan A,Burton P,Nottle P,Ellis S,Brown W

    更新日期:2021-01-19 00:00:00

  • Implementation of an Effective Strategy for Teaching Nontechnical Skills in the Operating Room: A Single-blinded Nonrandomized Trial.

    abstract:OBJECTIVE:To evaluate the effectiveness of debriefing and feedback on intraoperative nontechnical performance as an instructional strategy in surgical training. BACKGROUND:Regulatory authorities for accreditation in North America have included nontechnical skills such as communication and teamwork in the competencies ...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章

    doi:10.1097/SLA.0000000000001297

    authors: Dedy NJ,Fecso AB,Szasz P,Bonrath EM,Grantcharov TP

    更新日期:2016-05-01 00:00:00

  • Use of Prophylactic Mesh When Creating a Colostomy Does Not Prevent Parastomal Hernia: A Randomized Controlled Trial-STOMAMESH.

    abstract:OBJECTIVE:The aim of this study was to determine whether parastomal hernia (PSH) rate can be reduced by using synthetic mesh in the sublay position when constructing permanent end colostomy. The secondary aim was to investigate possible side-effects of the mesh. BACKGROUND:Prevention of PSH is important as it often ca...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1097/SLA.0000000000002542

    authors: Odensten C,Strigård K,Rutegård J,Dahlberg M,Ståhle U,Gunnarsson U,Näsvall P

    更新日期:2019-03-01 00:00:00

  • Growth-inhibitory effects of epidermal growth factor on human breast cancer and carcinoma of the esophagus transplanted into nude mice.

    abstract::The present work was performed to clarify the effects of epidermal growth factor (EGF) on the growth of human breast cancer and carcinoma of the esophagus. Human breast cancer MX-1, UM-1, and esophageal cancer ES-4 were transplanted to the subcutaneous tissue of nude mice. Human EGF (2 micrograms) was injected locally...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:

    authors: Murayama Y

    更新日期:1990-03-01 00:00:00

  • Improvement in treatment results and long-term survival of patients with esophageal cancer: impact of chemoradiation and change in treatment strategy.

    abstract:OBJECTIVE:To identify prognostic factors and reasons for improved survival over time in patients with esophageal cancer. SUMMARY BACKGROUND DATA:Management strategies for esophageal cancer have evolved with time. The impact of chemoradiation in the overall treatment results has not been adequately studied. METHODS:Fr...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/01.sla.0000086545.45918.ee

    authors: Law S,Kwong DL,Kwok KF,Wong KH,Chu KM,Sham JS,Wong J

    更新日期:2003-09-01 00:00:00

  • Gastroesophageal reflux: prevalence in adults older than 28 years after correction of esophageal atresia.

    abstract:OBJECTIVE:To study the incidence of gastroesophageal reflux (GER)related complications after correction of esophageal atresia (EA). SUMMARY BACKGROUND DATA:The association of EA and GER in children is well known. However, little is known about the prevalence of GER and its potential complications in adults who have un...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/01.sla.0000094303.07910.05

    authors: Deurloo JA,Ekkelkamp S,Bartelsman JF,Ten Kate FJ,Schoorl M,Heij HA,Aronson DC

    更新日期:2003-11-01 00:00:00

  • Appraisal of laparoscopic cholecystectomy.

    abstract::This paper reports the experience of three general surgeons performing 304 laparoscopic cholecystectomies in three private hospitals between October 1989 and November 1990. Laparoscopic cholecystectomy boasts two major advantages over the conventional procedure: the remarkable reduction in postoperative pain and econo...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199106000-00017

    authors: Graves HA Jr,Ballinger JF,Anderson WJ

    更新日期:1991-06-01 00:00:00

  • Physiologic sufficiency of regenerated lung lymphatics.

    abstract::The physiologic sufficiency of regenerated lung lymphatics after surgical transection of the lung hilum was studied experimentally. Dogs were prepared by surgical interruption of all left lung hilar tissues and structures except the skeletonized pulmonary artery and the pulmonary veins; continuity of the bronchus was ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198008000-00005

    authors: Thomas PA Jr

    更新日期:1980-08-01 00:00:00

  • Group IIA phospholipase A2 mediates lung injury in intestinal ischemia-reperfusion.

    abstract:OBJECTIVE:To assess the mechanistic role of group IIA phospholipase A2 (PLA2) in the process of local and distant organ injury after intestinal ischemia-reperfusion. SUMMARY BACKGROUND DATA:Intestinal ischemia-reperfusion produces lung injury by a mechanism that involves PLA2 activation, but it is unclear which isozym...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-200007000-00013

    authors: Koike K,Yamamoto Y,Hori Y,Ono T

    更新日期:2000-07-01 00:00:00

  • Multiple systems organ failure. Modulation of hepatocyte protein synthesis by endotoxin activated Kupffer cells.

    abstract::The etiology of hepatic insufficiency associated with the multiple systems organ failure (MSOF) syndrome is unclear. The authors have investigated the possibility that a macrophage/Kupffer cell mediated modulation of hepatocyte function may play a role in this phenomenon. Isolated rat hepatocytes were cultured, and th...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:

    authors: Keller GA,West MA,Cerra FB,Simmons RL

    更新日期:1985-01-01 00:00:00

  • Surgical Techniques and Long-term Outcomes of Living-donor Liver Transplantation With Inferior Vena Cava Replacement Using Atriocaval Synthetic Interposition Graft for Budd-Chiari Syndrome.

    abstract:OBJECTIVE:We aimed to describe our living-donor liver transplantation (LDLT) surgical technique and its long-term patency for patients with Budd-Chiari syndrome (BCS) and retrohepatic inferior vena cava (IVC) obstruction that extends up to the atrium. BACKGROUND:From a technical perspective, LDLT for BCS with an IVC o...

    journal_title:Annals of surgery

    pub_type: 信件

    doi:10.1097/SLA.0000000000002847

    authors: Yoon YI,Lee SG,Moon DB,Ahn CS,Hwang S,Kim KH,Ha TY,Song GW,Jung DH,Park GC,Kim DS,Choo SJ

    更新日期:2019-04-01 00:00:00

  • High-grade extremity soft tissue sarcomas: factors predictive of local recurrence and its effect on morbidity and mortality.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/01.SLA.0000048448.56448.70

    authors: Eilber FC,Rosen G,Nelson SD,Selch M,Dorey F,Eckardt J,Eilber FR

    更新日期:2003-02-01 00:00:00

  • Paradigm shift in the management of gastroesophageal reflux disease.

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    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章

    doi:10.1097/01.SLA.0000064358.25509.36

    authors: Richards WO,Houston HL,Torquati A,Khaitan L,Holzman MD,Sharp KW

    更新日期:2003-05-01 00:00:00

  • Recurrent inguinal hernia.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198512000-00019

    authors: Postlethwait RW

    更新日期:1985-12-01 00:00:00

  • Impact of hospital volume on in-hospital mortality of infants undergoing repair of congenital diaphragmatic hernia.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e3181f5b538

    authors: Bucher BT,Guth RM,Saito JM,Najaf T,Warner BW

    更新日期:2010-10-01 00:00:00

  • Improved kidney graft function after preservation using a novel hypothermic machine perfusion device.

    abstract:OBJECTIVE:To study graft function and ischemia/reperfusion injury of porcine kidneys after preservation with the new Groningen Machine Perfusion (GMP) system versus static cold storage (CS). INTRODUCTION:The increasing proportion of marginal and nonheart beating donors necessitates better preservation methods to maint...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e31815c4019

    authors: Maathuis MH,Manekeller S,van der Plaats A,Leuvenink HG,'t Hart NA,Lier AB,Rakhorst G,Ploeg RJ,Minor T

    更新日期:2007-12-01 00:00:00