Breast cancer molecular phenotype and the use of HER2-targeted agents influence the accuracy of breast MRI after neoadjuvant chemotherapy.

Abstract:

OBJECTIVE:To investigate whether the accuracy of magnetic resonance imaging (MRI) after neoadjuvant systemic therapy (NST) is affected by molecular features of primary breast cancer and the use of human epidermal growth factor receptor 2 (HER2)-targeted agents. BACKGROUND:Improved understanding of factors affecting the accuracy of breast MRI after NST can lead to more tailored use of MRI in deciding surgical extent after NST. METHODS:We analyzed the imaging and clinicopathological data of 463 patients who underwent NST. We aimed to investigate whether the molecular subtypes, and the use of targeted therapies, were associated with changes in the accuracy of MRI predicting residual tumor extent. RESULTS:The accuracy of MRI predicting the residual tumor extent was most accurate in triple-negative breast cancer and was least accurate in Luminal A subtype (Pearson correlation coefficient of 0.754 and 0.531, respectively). Multivariate analysis suggested estrogen receptor (ER) status as an independent factor influencing the MRI accuracy. In HER2-amplified tumors, the use of HER2-targeted agents was associated with a less accurate MRI prediction. CONCLUSIONS:The accuracy of MRI in predicting residual tumor extent was lowest in ER-positive tumors treated with NST. In HER2-positive tumors, the use of HER2-targeted agents resulted in a less accurate MRI after NST. These factors should be considered for deciding the extent of breast conservation after neoadjuvant chemotherapy.

journal_name

Ann Surg

journal_title

Annals of surgery

authors

Moon HG,Han W,Ahn SK,Cho N,Moon WK,Im SA,Park IA,Noh DY

doi

10.1097/SLA.0b013e3182686bd9

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

133-7

issue

1

eissn

0003-4932

issn

1528-1140

journal_volume

257

pub_type

杂志文章
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    authors: Schauer PR,Ikramuddin S,Gourash W,Ramanathan R,Luketich J

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    authors: Somers RG,Jablon LK,Kaplan MJ,Sandler GL,Rosenblatt NK

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    doi:10.1097/00000658-197406000-00008

    authors: Haimov M,Glabman S,Schupak E,Neff M,Burrows L

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