Abstract：
BACKGROUND:Acetazolamide has been reported to be effective in the prevention of acute mountain sickness (AMS). Our aim was to conduct a systematic review of randomized, placebo-controlled trials of acetazolamide in the prevention of AMS. METHODS:Studies were identified by searching the MEDLINE, Embase, Cochrane Clinical Trials Register, and ClinicalTrials.gov databases. Primary end point was difference in incidence of AMS between acetazolamide and placebo groups. RESULTS:Acetazolamide prophylaxis was associated with a 48% relative-risk reduction compared to placebo. There was no evidence of an association between efficacy and dose of acetazolamide. Adverse effects were often not systematically reported but appeared to be common but generally mild. One study found that adverse effects of acetazolamide were dose related. CONCLUSIONS:Acetazolamide is effective prophylaxis for the prevention of symptoms of AMS in those going to high altitude. A dose of 250 mg/day has similar efficacy to higher doses and may have a favorable side-effect profile.
journal_name
J Travel Medjournal_title
Journal of travel medicineauthors
Ritchie ND,Baggott AV,Andrew Todd WTdoi
10.1111/j.1708-8305.2012.00629.xsubject
Has Abstractpub_date
2012-09-01 00:00:00pages
298-307issue
5eissn
1195-1982issn
1708-8305journal_volume
19pub_type
杂志文章,meta分析,评审abstract：:Whether the result of cyclical atmospheric changes, anthropogenic activities, or combinations of both, authorities now agree that the earth is warming from a variety of climatic effects, including the cascading effects of greenhouse gas emissions to support human activities. To date, most reports of the public health ...
journal_title：Journal of travel medicine
pub_type： 杂志文章,评审
doi：10.1111/j.1708-8305.2006.00072.x
更新日期：2006-11-01 00:00:00
abstract：:Background: Brucellosis is an endemic disease in Latin America and other countries. Serologic cross-reaction between cholera and Brucella infection is well recognized. Since the introduction to cholera in 1991 in Latin America, interpreting serologic tests has become potentially problematic. This study attempts to eva...
journal_title：Journal of travel medicine
pub_type： 杂志文章
doi：10.1111/j.1708-8305.1996.tb00694.x
更新日期：1996-03-01 00:00:00
abstract：BACKGROUND:Pontiac fever (PF), a legionellosis with influenza-like symptoms and high attack rates, is rarely reported. Travel-related outbreaks can elude detection because infected persons are often widely removed geographically from the transmission source before illness onset. Thirty-one persons staying at an Illinoi...
journal_title：Journal of travel medicine
pub_type： 杂志文章
doi：10.2310/7060.2005.12401
更新日期：2005-07-01 00:00:00
abstract：Background:Travel medicine needs are changing. New patterns of travel, including greater travel by individuals from emerging economies with different values in costs, risks and benefits, must be considered. This review aims to (1) highlight selected studies that have been published that address previously identified ga...
journal_title：Journal of travel medicine
pub_type： 杂志文章
doi：10.1093/jtm/tax001
更新日期：2017-07-01 00:00:00
abstract：:We describe a 55-year-old man returning from the Philippines infected with a hookworm, the novel bacterium Laribacter hongkongensis, and a Blastocystis hominis and presenting with both gastrointestinal and neurological symptoms. The high eosinophilia caused by the hookworm infection resulted in both gastrointestinal a...
journal_title：Journal of travel medicine
pub_type： 杂志文章
doi：10.1111/jtm.12042
更新日期：2013-07-01 00:00:00
abstract：OBJECTIVE:Scarce data are available on the occurrence of ailments and diseases in children during travel. We studied the characteristics and frequencies of ailments in children aged 0 to 18 years and their parents during traveling. METHODS:A prospective observational study on ailments reported by children and parents ...
journal_title：Journal of travel medicine
pub_type： 杂志文章
doi：10.1111/j.1708-8305.2011.00551.x
更新日期：2012-05-01 00:00:00
abstract：:A 34-year-old patient presented with giant, transient urticarial skin lesions and periorbital edema after a 3-month stay in DR Congo. Retrospective analysis of stored samples revealed that these signs were prodromal manifestations of acute hepatitis B infection. The hepatitis B infection was spontaneously cleared; the...
journal_title：Journal of travel medicine
pub_type： 杂志文章
doi：10.1111/j.1708-8305.2011.00507.x
更新日期：2011-05-01 00:00:00
abstract：:Loiasis, caused by the filarial nematode Loa loa, is often asymptomatic but frequently manifests as episodic angioedema and periocular migration of adult worms. Hence also known as the eye worm.(1) It is rarely encountered in the United States among travelers and immigrants. This report describes a case of loiasis in ...
journal_title：Journal of travel medicine
pub_type： 杂志文章
doi：10.1111/j.1708-8305.2007.00166.x
更新日期：2008-01-01 00:00:00
abstract：OBJECTIVE:To evaluate travel health knowledge, attitudes, and practices on vaccination and malaria prevention among Spanish travelers to the tropics. METHODS:A cross-sectional survey was carried out in the departure lounge of the two main Spanish international airports in the summer of 2004. A questionnaire was admini...
journal_title：Journal of travel medicine
pub_type： 杂志文章
doi：10.1111/j.1708-8305.2007.00142.x
更新日期：2007-09-01 00:00:00
abstract：BACKGROUND:Medical emergencies often occur on commercial airline flights, but valid data on their causes and consequences are rare. Therefore, it is unclear what emergency medical equipment is necessary. Although a minimum standard for medical equipment is defined in regulations, additional material is not standardized...
journal_title：Journal of travel medicine
pub_type： 杂志文章
doi：10.1111/jtm.12138
更新日期：2014-09-01 00:00:00
abstract：BACKGROUND:The number of international trips undertaken by residents of the United Kingdom has risen dramatically over the past 50 years. Likewise, the numbers studying in higher education have also shown a huge increase. This study aimed to assess the appropriateness of advice given to traveling students by higher edu...
journal_title：Journal of travel medicine
pub_type： 杂志文章
doi：10.2310/7060.2004.19202
更新日期：2004-11-01 00:00:00
abstract：BACKGROUND:Health-care professionals can help travelers by providing accurate pre-travel counseling for mosquito-transmitted diseases such as malaria, yellow fever, and dengue fever. Governments and international organizations will benefit from knowledge survey among health professionals in this field to promote the de...
journal_title：Journal of travel medicine
pub_type： 杂志文章
doi：10.1111/j.1708-8305.2010.00483.x
更新日期：2011-01-01 00:00:00
abstract：:Acute rheumatic fever presenting as fever in a returned traveler has not previously been described. We report one such case. ...
journal_title：Journal of travel medicine
pub_type： 杂志文章
doi：10.2310/7060.2005.12611
更新日期：2005-11-01 00:00:00
abstract：BACKGROUND:We conducted a prospective study to evaluate the aetiologies of fever in returning travelers and to identify the clinical and laboratory factors predictive of malaria in travelers returning from tropical areas with fever. METHODS:We included those consulting for fever appearing less than 3 months after retu...
journal_title：Journal of travel medicine
pub_type： 杂志文章
doi：10.1111/j.1708-8305.2009.00382.x
更新日期：2010-03-01 00:00:00
abstract：Background:Dengue fever (DF) is a frequently imported arthropod-borne infection in the United Kingdom but its broad range of clinical presentations makes it potentially unrecognized by clinicians. Methods:We conducted a 6-year retrospective case note review of laboratory confirmed DF patients in East London in the per...
journal_title：Journal of travel medicine
pub_type： 杂志文章
doi：10.1093/jtm/tax015
更新日期：2017-05-01 00:00:00
abstract：:The object of the study was to determine the incidence rate of meningococcal disease in travelers originating in industrialized countries and visiting developing countries. Subjects were intercontinental travelers with meningococcal diseases acquired from 1986 to 1989. Health authorities in 108 countries were contacte...
journal_title：Journal of travel medicine
pub_type： 杂志文章
doi：10.1111/j.1708-8305.1994.tb00548.x
更新日期：1994-03-01 00:00:00
abstract：BACKGROUND:International travel and trade are known to be associated with the risk of spreading communicable diseases across borders. No international surveillance system for infectious diseases on ships exists. Outbreak reports and systematic studies mainly focus on disease activity on cruise ships. The study aims to ...
journal_title：Journal of travel medicine
pub_type： 杂志文章
doi：10.1111/j.1708-8305.2009.00343.x
更新日期：2009-11-01 00:00:00
abstract：BACKGROUND:The purpose of this study was to evaluate the tolerance and immunogenicity of a hepatitis A vaccine using immunopotentiating reconstituted influenza virosomes (IRIV) as adjuvant when administered simultaneously with a yellow fever vaccine (YFV). METHOD:An open prospective trial with two parallel groups was ...
journal_title：Journal of travel medicine
pub_type： 临床试验,杂志文章
doi：10.1111/j.1708-8305.1999.tb00523.x
更新日期：1999-12-01 00:00:00
abstract：:Travellers visiting friends and relatives (VFRs) often have complex pre-travel needs. We identified the characteristics, destinations, vaccinations and pre-travel advice provided to VFRs and compared these with non-VFR travellers. The significant differences we found suggest that future research should focus on improv...
journal_title：Journal of travel medicine
pub_type： 杂志文章
doi：10.1093/jtm/tax038
更新日期：2017-09-01 00:00:00
abstract：:We report the case of an Anthia sexmaculata sexmaculata-associated necrotic burn in a French expatriate in Mauritania. Anthia spp.-related injury is a common though underreported health issue in the Sahelo-Saharan area. Deployed soldiers and travellers should be aware of these beetles when adventuring in this region. ...
journal_title：Journal of travel medicine
pub_type： 杂志文章
doi：10.1093/jtm/tay033
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:Authorities have pledged to eliminate canine rabies by 2020 in Cambodia, a country with a very high rabies burden. Logistic and financial access to timely and adequate postexposure prophylaxis (PEP) is essential for preventing rabies in humans. METHODS:We undertook a survey of the few identified sites where...
journal_title：Journal of travel medicine
pub_type： 杂志文章
doi：10.1111/jtm.12228
更新日期：2015-09-01 00:00:00
abstract：:As tropical countries become common travelers' destinations, more and more returning travelers are expected to present with cutaneous lesions secondary to myiasis. The skin lesion starts as a small red papule and gradually enlarges to become a furuncle. Familiarity with the characteristic clinical presentation and pro...
journal_title：Journal of travel medicine
pub_type： 杂志文章
doi：10.2310/7060.2005.12411
更新日期：2005-07-01 00:00:00
abstract：:Hepatitis E virus (HEV) is the main etiological agent for the enterically transmitted form of non-A, non-B hepatitis (ET-NANB), and is associated with epidemic and sporadic forms of the disease,1 mainly in some developing countries.2 In Argentina, no ET-NANB hepatitis epidemics have been described, and no epidemiologi...
journal_title：Journal of travel medicine
pub_type： 杂志文章
doi：10.1111/j.1708-8305.1997.tb00788.x
更新日期：1997-06-01 00:00:00
abstract：AIM:International travel has become popular among young adults. This study evaluated the rate and characteristics of travel-associated health risks among young adults with type 1 diabetes mellitus (T1DM) compared with healthy same-aged individuals. METHODS:A retrospective study was conducted of 47 young adults with T1...
journal_title：Journal of travel medicine
pub_type： 杂志文章
doi：10.1111/jtm.12136
更新日期：2014-11-01 00:00:00
abstract：:Alternative approaches to malaria chemoprophylaxis are discussed in light of the difficulties of executing clinical trials within limits of infection rates and ethics. ...
journal_title：Journal of travel medicine
pub_type： 社论
doi：10.1093/jtm/taw065
更新日期：2016-09-30 00:00:00
abstract：:Mass gathering is well known to concentrate and amplify the transmission of infectious respiratory diseases. Here we report a possible case of coinfection with influenza A/H1N1 and varicella in a young French traveler returning from a rock festival in Hungary. We report a cluster of influenza A/H1N1 cases at this fest...
journal_title：Journal of travel medicine
pub_type： 杂志文章
doi：10.1111/j.1708-8305.2010.00410.x
更新日期：2010-05-01 00:00:00
abstract：BACKGROUND:Neurocysticercosis (NCC) is an important cause of adult-onset seizures in endemic areas, whereas it is emerging in some nonendemic areas as well because of extensive immigration. METHOD:We describe three cases of imported NCC recently admitted to San Bortolo Hospital in Vicenza, located in Northern Italy. ...
journal_title：Journal of travel medicine
pub_type： 杂志文章
doi：10.1111/jtm.12066
更新日期：2014-01-01 00:00:00
abstract：:A case of Japanese encephalitis virus (JEV) infection is reported in a young traveler returning from Thailand. Clinical suspicion of JEV in travelers returning from endemic areas with neurologic symptoms is warranted. Confirmation of the diagnosis is complex and requires specialized laboratory services. Individualized...
journal_title：Journal of travel medicine
pub_type： 杂志文章
doi：10.1111/j.1708-8305.2011.00582.x
更新日期：2012-03-01 00:00:00
abstract：:Shigella bacteremias are uncommon in immune-competent adults. We report two cases of Shigella flexneri bacteremia that occurred in healthy young travelers, who recovered. Self-medication with loperamide and ibuprofen without antibiotics (case 1) and concomitant falciparum malaria (case 2) were the only co-morbidities ...
journal_title：Journal of travel medicine
pub_type： 杂志文章
doi：10.1111/j.1708-8305.2012.00627.x
更新日期：2012-07-01 00:00:00
abstract：:A non-pregnant Canadian woman returning from India presented with a 1-week history of jaundice and malaise. Subsequently, she developed fulminant hepatic failure caused by hepatitis E virus (HEV). HEV can cause fulminant hepatic failure, most commonly in pregnant women and those with chronic liver disease; however, al...
journal_title：Journal of travel medicine
pub_type： 杂志文章
doi：10.1093/jtm/taw021
更新日期：2016-04-11 00:00:00
