Abstract：
PURPOSE:To study the anti-oxidant properties of neem (Azadirachta indica) in inducing apoptosis of cervical cancer cells and estimation of caspase activity and TNF-α and IFN-γ levels in monocytes of cervical cancer patients and controls. METHODS:Monocytes were cultured from blood samples of 65 study cases and 30 controls for the estimation of caspase 3, 8 and 9 with specific inhibitors and TNF-α and IFN-γ levels in culture supernatant of monocytes. Two cervical biopsies were taken from 18 cases of moderately differentiated SCC. One biopsy was formalin fixed for histopathology and the other for tissue culture was kept in RPMI-1640 medium to evaluate the apoptotic effect of neem extract on malignant cells. RESULTS:Neem-treated monocytes from cervical cancer patients showed high activity levels of caspase 3, 8, and 9. A decrease in TNF-α and an increase in IFN-γ levels was seen in culture supernatant of monocytes. Cyto- and histomorphology of neem-treated cervical cancer cells exhibited increased apoptosis. CONCLUSION:Neem is a potent inducer of apoptosis in biopsies of cervical cancer patients.
journal_name
Arch Gynecol Obstetjournal_title
Archives of gynecology and obstetricsauthors
Vasenwala SM,Seth R,Haider N,Islam N,Khan T,Maheshwari V,Ur Rehman Sdoi
10.1007/s00404-012-2428-xsubject
Has Abstractpub_date
2012-11-01 00:00:00pages
1255-9issue
5eissn
0932-0067issn
1432-0711journal_volume
286pub_type
杂志文章abstract：PURPOSE:We aimed to investigate the impact of early versus late discharge following cesarean delivery (CD) on re-admission rate. METHODS:This is a retrospective cohort study of all CDs performed between 2013 and 2016. Patients who underwent CD between 01/13 and 12/14, were routinely discharged on postoperative day (PO...
journal_title：Archives of gynecology and obstetrics
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journal_title：Archives of gynecology and obstetrics
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journal_title：Archives of gynecology and obstetrics
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journal_title：Archives of gynecology and obstetrics
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journal_title：Archives of gynecology and obstetrics
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journal_title：Archives of gynecology and obstetrics
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journal_title：Archives of gynecology and obstetrics
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journal_title：Archives of gynecology and obstetrics
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journal_title：Archives of gynecology and obstetrics
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journal_title：Archives of gynecology and obstetrics
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journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
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更新日期：2019-10-01 00:00:00
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journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
doi：10.1007/s00404-019-05191-z
更新日期：2019-08-01 00:00:00
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journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
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更新日期：2018-08-01 00:00:00
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journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
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更新日期：2003-02-01 00:00:00
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journal_title：Archives of gynecology and obstetrics
pub_type： 杂志文章
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更新日期：2014-06-01 00:00:00
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journal_title：Archives of gynecology and obstetrics
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