Abstract:
BACKGROUND:Palliative chemotherapy is often administered to terminally ill cancer patients to relieve symptoms. Yet, unnecessary use of chemotherapy can worsen patients' quality of life due to treatment-related toxicities. Thus, accurate prediction of survival in terminally ill patients can help clinicians decide on the most appropriate palliative care for these patients. However, studies have shown that clinicians often make imprecise predictions of survival in cancer patients. Hence, the purpose of this study was to create a clinical decision support tool to predict survival in cancer patients beyond 120 days after palliative chemotherapy. MATERIALS AND METHODS:Data were obtained from a retrospective study of 400 randomly selected terminally ill cancer patients in the National Cancer Centre Singapore (NCCS) from 2008 to 2009. After removing patients with missing data, there were 325 patients remaining for model development. Three classification algorithms, naive Bayes (NB), neural network (NN), and support vector machine (SVM) were used to create the models. A final model with the best prediction performance was then selected to develop the tool. RESULTS:The NN model had the best prediction performance. The accuracy, specificity, sensitivity, and area under the curve (AUC) of this model were 78%, 82%, 74%, and 0.857, respectively. Five patient attributes (albumin level, alanine transaminase level (ATL), absolute neutrophil count, Eastern Cooperative Oncology Group (ECOG) status, and number of metastatic sites) were included in the model. CONCLUSIONS:A decision support tool to predict survival in cancer patients beyond 120 days after palliative chemotherapy was created. With further validation, this tool coupled with the professional judgment of clinicians can help improve patient care.
journal_name
J Palliat Medjournal_title
Journal of palliative medicineauthors
Ng T,Chew L,Yap CWdoi
10.1089/jpm.2011.0417subject
Has Abstractpub_date
2012-08-01 00:00:00pages
863-9issue
8eissn
1096-6218issn
1557-7740journal_volume
15pub_type
杂志文章abstract:BACKGROUND:Respiratory signs and symptoms are commonly encountered by physicians who care for cancer patients. Supplemental oxygen (SOx) has long been used for treatment of hypoxic respiratory insufficiency, but data reveal mixed efficacy results. The use and outcome patterns of technologically advanced oxygen delivery...
journal_title:Journal of palliative medicine
pub_type: 杂志文章
doi:10.1089/jpm.2011.0005
更新日期:2011-07-01 00:00:00
abstract:OBJECTIVES:Continuity, coordination, and transitions of care are key to high-quality medical care for patients with serious and advanced illness. We conducted a systematic review to evaluate the impact of interventions targeting these areas in this population. METHODS:We searched PubMed, CINAHL, PsycINFO, Cochrane, an...
journal_title:Journal of palliative medicine
pub_type: 杂志文章,meta分析,评审
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pub_type: 杂志文章
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journal_title:Journal of palliative medicine
pub_type: 杂志文章,评审
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更新日期:2005-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1089/jpm.2005.8.492
更新日期:2005-06-01 00:00:00
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doi:10.1089/jpm.2020.0020
更新日期:2020-09-03 00:00:00
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journal_title:Journal of palliative medicine
pub_type: 共识发展会议,杂志文章
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更新日期:2013-01-01 00:00:00
abstract::A faculty development course was offered at the Medical College of Wisconsin to bolster existing medical student and housestaff training opportunities in palliative medicine. An 8- week, 12 contact-hour course was designed to provide up to 15 faculty members training in the practice and teaching of end-of-life care. F...
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journal_title:Journal of palliative medicine
pub_type: 杂志文章
doi:10.1089/jpm.2018.0134
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journal_title:Journal of palliative medicine
pub_type: 杂志文章
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journal_title:Journal of palliative medicine
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更新日期:2020-05-01 00:00:00
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journal_title:Journal of palliative medicine
pub_type: 杂志文章
doi:10.1089/jpm.2006.0240
更新日期:2007-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1089/jpm.2011.0069
更新日期:2011-09-01 00:00:00
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journal_title:Journal of palliative medicine
pub_type: 杂志文章
doi:10.1089/jpm.2011.0092
更新日期:2011-10-01 00:00:00
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journal_title:Journal of palliative medicine
pub_type: 杂志文章
doi:10.1089/jpm.2018.0428
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journal_title:Journal of palliative medicine
pub_type: 杂志文章,多中心研究
doi:10.1089/jpm.2015.0266
更新日期:2016-03-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2012-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2001-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:2019-02-01 00:00:00
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journal_title:Journal of palliative medicine
pub_type: 杂志文章
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更新日期:2005-02-01 00:00:00
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journal_title:Journal of palliative medicine
pub_type: 杂志文章
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更新日期:2020-06-01 00:00:00
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journal_title:Journal of palliative medicine
pub_type: 杂志文章
doi:10.1089/jpm.2008.0244
更新日期:2009-05-01 00:00:00
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更新日期:2020-02-01 00:00:00