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Spliceosome and other novel mutations in chronic lymphocytic leukemia and myeloid malignancies.

Abstract：

:Spliceosome mutations represent a new generation of acquired genetic alterations that affect both myeloid and lymphoid malignancies. A substantial proportion of patients with myelodysplastic syndromes (MDSs) or chronic lymphocytic leukemia (CLL) harbor such mutations, which are often missense in type. Genotype-phenotype associations have been demonstrated for one of these mutations, SF3B1, with ring sideroblasts in MDS and 11q22 deletions in CLL. Spliceosome mutations might result in defective spliceosome assembly, deregulated global mRNA splicing, nuclear-cytoplasm export and altered expression of multiple genes. Such mutations are infrequent in other lymphomas, which instead display a separate group of novel mutations involving genes whose products are believed to affect histone acetylation and methylation and chromatin structure (for example, EZH2 and MLL2). On the other hand, some mutations (for example, NOTCH1) occur in both CLL and other immature and mature lymphoid malignancies. In the current review, we discuss potential mechanisms of cell transformation associated with spliceosome mutations, touch upon the increasing evidence regarding the clonal involvement of hematopoietic stem cells in some cases of otherwise mature lymphoid disorders and summarize recent information on recently described mutations in lymphomas.

journal_name

Leukemia

journal_title

Leukemia

authors

Damm F,Nguyen-Khac F,Fontenay M,Bernard OA

doi

10.1038/leu.2012.86

subject

Has Abstract

pub_date

2012-09-01 00:00:00

pages

2027-31

issue

9

eissn

0887-6924

issn

1476-5551

pii

leu201286

journal_volume

26

pub_type

杂志文章,评审

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