The effect of bambuterol on plasma cholinesterase activity and suxamethonium-induced neuromuscular blockade in subjects heterozygous for abnormal plasma cholinesterase.

Abstract:

:Bambuterol is a new bronchodilator which is also a reversible inhibitor of plasma cholinesterase. In patients with normal plasma cholinesterase genotype, bambuterol prolongs suxamethonium-induced neuromuscular blockade. In the present study, we investigated the interaction of bambuterol and suxamethonium in nine patients heterozygous for abnormal plasma cholinesterase during anaesthesia with fentanyl, thiopentone, halothane and nitrous oxide in oxygen. The patients (seven E1uE1a and two E1uE1s) were given 20 mg of bambuterol orally 2 h before anaesthesia. Suxamethonium 1 mg.kg-1 was given for tracheal intubation. The neuromuscular function was monitored using train-of-four (TOF) stimulation of the ulnar nerve and a force displacement transducer. Plasma cholinesterase activity decreased in all patients following bambuterol (P less than 0.001). In patients with genotype E1uE1a, median time to 90% recovery of twitch height and TOF ratio greater than or equal to 0.7 (37.5 min) was prolonged compared to 28 E1uE1a patients not treated with bambuterol (14.0 min) (P less than 0.001). Four of these patients developed a phase II block apparently not correlated to plasma cholinesterase activity. In the E1uE1s; patients, full recovery was seen after 22.0 and 31.4 min, respectively. It is concluded that in patients heterozygous for abnormal plasma cholinesterase, bambuterol 20 mg taken 2 h before anaesthesia causes a 2-3 times prolongation of the neuromuscular blockade following suxamethonium 1 mg.kg-1 and in some patients a phase II block.

authors

Bang U,Viby-Mogensen J,Wirén JE

doi

10.1111/j.1399-6576.1990.tb03153.x

subject

Has Abstract

pub_date

1990-10-01 00:00:00

pages

600-4

issue

7

eissn

0001-5172

issn

1399-6576

journal_volume

34

pub_type

杂志文章
  • Spinal sufentanil in rats: Part I: Epidural versus intrathecal sufentanil and morphine.

    abstract::Male Wistar rats were injected epidurally or intrathecally with increasing doses of sufentanil or morphine in order to determine differences in potency, onset and duration of analgesia and supra-spinal side-effects. For sufentanil, only small differences in the lowest ED50-values for analgesia and supra-spinal side-ef...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1992.tb03449.x

    authors: Boersma FP,Meert TF,Vercauteren M

    更新日期:1992-02-01 00:00:00

  • Hepatopulmonary syndrome: a concern for the anesthetist? Pre-operative evaluation of hypoxemic patients with liver disease.

    abstract::Liver cirrhosis and other chronic hepatic diseases are followed in a subset of affected patients by gas exchange abnormalities resulting from a syndrome called hepatopulmonary syndrome (HPS). The structural basis of this clinical entity is an alteration of pulmonary vasculature resulting in abnormal vasodilatation and...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章,评审

    doi:10.1111/j.0001-5172.2004.00282.x

    authors: Mazzeo AT,Lucanto T,Santamaria LB

    更新日期:2004-02-01 00:00:00

  • Direct myocardial depressant effect of naloxone: mechanical and electrophysiological actions in vitro.

    abstract:BACKGROUND:Naloxone, an opioid antagonist, has a cardiovascular pressor effect and has been used in various types of shock states. The aim was to determine the non-opioid effect on direct cardiac muscle contractility and explore the mechanism using guinea pig right ventricular papillary muscles. METHODS:With instituti...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.2004.00267.x

    authors: Kim KJ,Chung NS,Park WK

    更新日期:2004-01-01 00:00:00

  • Anaesthetic-induced cardioprotection in an experimental model of the Takotsubo syndrome - isoflurane vs. propofol.

    abstract:BACKGROUND:Takotsubo syndrome (TS) is an acute cardiac condition with a substantial mortality for which no specific treatment is available. We have previously shown that isoflurane attenuates the development of left ventricular (LV) dysfunction in an experimental TS-model. We compared the effects of equi-anaesthetic do...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/aas.12857

    authors: Oras J,Redfors B,Ali A,Lundgren J,Sihlbom C,Thorsell A,Seeman-Lodding H,Omerovic E,Ricksten SE

    更新日期:2017-03-01 00:00:00

  • Bupivacaine does not suppress cardiac sympathetic nerve activity during halothane anesthesia in the cat.

    abstract:BACKGROUND:The finding that i.v. lidocaine suppresses cardiac sympathetic nerve activity during 1 MAC halothane, but not during 2 MAC or 3 MAC halothane, suggests that the neurally mediated circulatory effects of i.v. local anesthetics may vary with background autonomic activity. This study aimed to compare the effects...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1997.tb04749.x

    authors: Nishikawa K,Terai T,Morimoto O,Yukioka H,Asada A

    更新日期:1997-05-01 00:00:00

  • Effect of the menstrual cycle phase on post-operative pain perception and analgesic requirements.

    abstract:BACKGROUND:Research has shown that menstrual cycle phase may affect pain sensitivity. There is a lack of studies evaluating this effect on post-operative pain and analgesic needs. METHODS:In this prospective cohort study, we determined the effect of menstrual cycle phase on pain perception and analgesic requirements f...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.2012.02661.x

    authors: Ahmed A,Khan F,Ali M,Haqnawaz F,Hussain A,Azam SI

    更新日期:2012-05-01 00:00:00

  • Measurement of acceleration: a new method of monitoring neuromuscular function.

    abstract::A new method for monitoring neuromuscular function based on measurement of acceleration is presented. The rationale behind the method is Newton's second law, stating that the acceleration is directly proportional to the force. For measurement of acceleration, a piezo-electric ceramic wafer was used. When this piezo el...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1988.tb02686.x

    authors: Viby-Mogensen J,Jensen E,Werner M,Nielsen HK

    更新日期:1988-01-01 00:00:00

  • CT-proAVP (copeptin), MR-proANP and Peroxiredoxin 4 after cardiac arrest: release profiles and correlation to outcome.

    abstract:BACKGROUND:Further characterization of the post-cardiac arrest syndrome (PCAS) is essential to better understand the mechanisms resulting in injury and death. We investigated serial serum concentrations of the stress hormone c-terminal provasopressin (CT-proAVP or copeptin), the cardiac biomarker MR-proANP and a biomar...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/aas.12282

    authors: Annborn M,Dankiewicz J,Nielsen N,Rundgren M,Smith JG,Hertel S,Struck J,Friberg H

    更新日期:2014-04-01 00:00:00

  • Early predictability of the need for tracheotomy after admission to ICU: an observational study.

    abstract:BACKGROUND:The goal of this study was to explore the ability of professional judgment to predict the need for tracheotomy early among intensive care unit (ICU) patients. METHODS:Prospective study using daily questionnaires among ICU physicians in a mixed medical-surgical ICU. The prediction of tracheotomy was by a vis...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.2010.02290.x

    authors: Veelo DP,Binnekade JM,Buddeke AW,Dongelmans DA,Schultz MJ

    更新日期:2010-10-01 00:00:00

  • Long-term outcome after neurosurgically treated spinal epidural abscess following epidural analgesia.

    abstract:BACKGROUND:A recent investigation demonstrated a high incidence of epidural abscess secondary to epidural catheterization and a 50% frequency of neurologic deficits. We studied short- and long-term neurologic outcome in patients operated for spinal epidural abscess after epidural analgesia. METHODS:Nineteen patients w...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章

    doi:10.1034/j.1399-6576.2001.450215.x

    authors: Wang LP,Hauerberg J,Schmidt JF

    更新日期:2001-02-01 00:00:00

  • Induction and mechanism of apoptotic cell death by propofol in HL-60 cells.

    abstract:BACKGROUND:Apoptosis (programmed cell death) occurs in various physiological and pathological conditions, exhibits a characteristic mechanism of intracellular sequential reaction and may be involved in determining clinical outcome. The antioxidant activity of propofol (2,6-diisopropylphenol) together with the stimulati...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1399-6576.2002.460903.x

    authors: Tsuchiya M,Asada A,Arita K,Utsumi T,Yoshida T,Sato EF,Utsumi K,Inoue M

    更新日期:2002-10-01 00:00:00

  • Persistent opioid use and socio-economic factors: a population-based study in Norway.

    abstract:BACKGROUND:A growing proportion of the population is using opioids for longer time periods, but little is known about the characteristics of patients who are persistent opioid users. We therefore studied the association between socio-economic factors and persistent vs. short-term opioid use 4 years later. METHODS:The ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/aas.12281

    authors: Svendsen K,Fredheim OM,Romundstad P,Borchgrevink PC,Skurtveit S

    更新日期:2014-04-01 00:00:00

  • Haemodynamics and myocardial oxygenation during anaesthesia for coronary artery surgery: comparison between enflurane and high-dose fentanyl anaesthesia.

    abstract::Changes in central and coronary haemodynamics and myocardial oxygenation during anaesthesia induction, intubation, skin incision and sternotomy were studied in 24 patients undergoing a coronary artery bypass grafting operation under either high-dose fentanyl or enflurane anaesthesia. The anaesthesia induction caused n...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1985.tb02234.x

    authors: Heikkilä H,Jalonen J,Arola M,Laaksonen V

    更新日期:1985-07-01 00:00:00

  • Influence of non-volatile anesthetics on the migration behavior of the human breast cancer cell line MDA-MB-468.

    abstract:BACKGROUND:Anesthetic agents are known to influence functions of the immune system. Anesthetic drugs also support cancer progression by suppressing the activity of immune cells. In breast carcinoma an increase in expression of peripheral-type benzodiazepine receptors (PBR) and the gamma aminobutyl acid (GABA) level has...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1399-6576.2002.460714.x

    authors: Garib V,Niggemann B,Zänker KS,Brandt L,Kubens BS

    更新日期:2002-08-01 00:00:00

  • Analgesic, respiratory and endocrine responses in normal man to THIP, a GABA-agonist.

    abstract::In a controlled study, the effects of THIP (a synthetic gamma-aminobutyric-acid-agonist) on respiratory function (ventilatory response to CO2), first detection of stimulation (electrical stimulation of a tooth), pain threshold, magnitude of maximal tolerated pain stimulation, and plasma cortisol, prolactin and glucose...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1983.tb01896.x

    authors: Lindeburg T,Følsgård S,Sillesen H,Jacobsen E,Kehlet H

    更新日期:1983-02-01 00:00:00

  • Rapid reversal of global left ventricular dysfunction after accidental injection of 0.75 mg epinephrine in a 20-year-old patient.

    abstract::We report an accidental injection of epinephrine before spinal anaesthesia in a 20-year-old patient who subsequently developed immediate myocardial ischemia and global left ventricular dysfunction (ejection fraction of 20%). Hemodynamic status dramatically improved after nitroglycerin, calcium antagonists, acetyl sali...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.0001-5172.2004.00428.x

    authors: Meaudre E,Barbou F,Sallaberry M,Cantais E,Petit D,Palmier B

    更新日期:2004-08-01 00:00:00

  • Arterial hypotension and hypoxaemia during total hip replacement: the importance of thromboplastic products, fat embolism and acrylic monomers.

    abstract::Thirteen patients submitted to total hip replacement surgery by the Charnley technique were studied. Operations were performed under epidural analgesia with the patients awake and breathing air. During the surgical procedure, the magnitude of tissue-thromboplastic activity, the amount of fat globules, the presence of ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1975.tb05219.x

    authors: Modig J,Busch C,Olerud S,Saldeen T,Waernbaum G

    更新日期:1975-01-01 00:00:00

  • The influence of halothane on spermatogenesis in surgical patients.

    abstract::Seventeen male patients delivered a sperm sample before and 80-90 days after halothane anaesthesia, acting as their own control. The sample was tested according to WHO criteria. There was no difference before and after anaesthesia. We conclude that halothane used in normal anaesthetic concentration in combination with...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1992.tb03437.x

    authors: Andersen BN,Mortensen JT,Hansen P,Jakobsen J,Johansen JP

    更新日期:1992-02-01 00:00:00

  • Severe complications associated with epidural and spinal anaesthesias in Finland 1987-1993. A study based on patient insurance claims [see comment].

    abstract:BACKGROUND:The Patient Injury Act has been in effect in Finland since 1 May 1987. This legislation is a no-fault compensation scheme and implies that if a patient during the course of medical treatment suffers any injury as a result of that treatment he or she may file a claim to the Patient Insurance Association (PIA)...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1997.tb04722.x

    authors: Aromaa U,Lahdensuu M,Cozanitis DA

    更新日期:1997-04-01 00:00:00

  • Forgoing life sustaining treatments: differences and similarities between North America and Europe.

    abstract:BACKGROUND:As evidence exist that severe neurological damage or prolonged death after inappropriate CPR could occur, restraints and indications for CPR were perceived as necessary. The objective of this review is to examine policies and attitudes towards end-of-life decisions in Europe and North America and to outline ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章,评审

    doi:10.1111/j.1399-6576.2006.01150.x

    authors: Moselli NM,Debernardi F,Piovano F

    更新日期:2006-11-01 00:00:00

  • Effects of autotransfusion of mediastinal shed blood on biochemical markers of myocardial damage in coronary surgery.

    abstract:BACKGROUND:Previous studies have shown conflicting results regarding the effect of autotransfusion of mediastinal shed blood after coronary artery bypass grafting (CABG) on the serum levels of myocardial band (MB) isoenzymes of creatine kinase (CK-MB) and cardiac troponins. The effect of autotransfusion on serum levels...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.2005.00810.x

    authors: Pleym H,Tjomsland O,Asberg A,Lydersen S,Wahba A,Bjella L,Dale O,Stenseth R

    更新日期:2005-10-01 00:00:00

  • Influence of body temperature during cardiopulmonary bypass on the haemodynamics early after aorto-coronary bypass surgery.

    abstract::The haemodynamic adaptation early after aorto-coronary bypass surgery, with special reference to the influence of body temperature on postoperative vasoconstriction, was studied in 20 patients. Cardioplegia arrest was used in all cases. Eleven patients were cooled to 30 degrees C during cardiopulmonary bypass, and nin...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1979.tb01485.x

    authors: Tydén H

    更新日期:1979-12-01 00:00:00

  • Ultrasound-guided peripheral nerve blocks: what are the benefits?

    abstract:BACKGROUND:Use of ultrasound by anaesthesiologists performing regional blocks is rapidly gaining popularity. The aims of this review were to summarize and update accumulating evidence on ultrasound-guided nerve blocks, with an emphasis on the clinical relevance of the results and to critically appraise changing standar...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章,评审

    doi:10.1111/j.1399-6576.2008.01666.x

    authors: Koscielniak-Nielsen ZJ

    更新日期:2008-07-01 00:00:00

  • A study of ECG abnormalities and myocardial specific enzymes in patients with subarachnoid haemorrhage.

    abstract::Twenty-two patients with subarachnoid haemorrhage were investigated for changes in myoglobin, total CK, CK-MB and CK-BB in serum and for the incidence of ECG abnormalities. Serial ECG's showed abnormalities in 20 patients; 15 of these had T wave changes, 15 Q-Tc prolongation, ten had S-T depression and nine U waves an...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1982.tb01779.x

    authors: Rudehill A,Gordon E,Sundqvist K,Sylvén C,Wahlgren NG

    更新日期:1982-08-01 00:00:00

  • Haemodynamic and metabolic effects of resuscitation with Ringer's ethyl pyruvate in the acute phase of porcine endotoxaemic shock.

    abstract:BACKGROUND:Ethyl pyruvate has been shown to possess anti-inflammatory and free radical scavenging properties. However, the haemodynamic effects of ethyl pyruvate have not been studied in detail. We investigated the systemic, regional and microcirculatory haemodynamic and metabolic effects of resuscitation with Ringer's...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.2006.01140.x

    authors: Andersson A,Fenhammar J,Frithiof R,Sollevi A,Hjelmqvist H

    更新日期:2006-11-01 00:00:00

  • Dexamethasone for pain after outpatient shoulder surgery: a randomised, double-blind, placebo-controlled trial.

    abstract:BACKGROUND:Dexamethasone has analgesic properties when given intravenously before surgery, but the optimal dose has not been determined. We hypothesised that a dose of 40 mg dexamethasone would improve analgesia after outpatient shoulder surgery compared with 8 mg. METHODS:A randomised, double-blind, placebo-controlle...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/aas.12333

    authors: Bjørnholdt KT,Mønsted PN,Søballe K,Nikolajsen L

    更新日期:2014-07-01 00:00:00

  • Propofol-fentanyl anesthesia compared to thiopental-halothane with special reference to recovery and vomiting after pediatric strabismus surgery.

    abstract::Forty-four children, ASA physical status I or II, aged 1.5-14 years and admitted for strabismus surgery, were studied. The study compared the postoperative condition after two different anesthesia methods. All children were premedicated with midazolam rectally, received glycopyrrolate i.v. and were then randomised to ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.1992.tb03448.x

    authors: Larsson S,Asgeirsson B,Magnusson J

    更新日期:1992-02-01 00:00:00

  • Heat and moisture exchangers and the body temperature: a peroperative study.

    abstract::The importance of conditioning the inhaled gas for maintaining the body temperature during artificial respiration was investigated. The mean body temperature (MBT) was deduced from readings from five measuring sites, four of which were situated at the skin and the fifth in the rectum. Temperature recordings were made ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1399-6576.1990.tb03141.x

    authors: Eckerbom B,Lindholm CE

    更新日期:1990-10-01 00:00:00

  • Effects of high dose E. coli lipopolysaccharide on rabbit lung function, and of subsequent addition of chemotactic granulocyte activators to their isolated, blood-perfused lungs.

    abstract::E. coli LPS was infused (1 microgram/kg to 5 mg/kg over 30 min) to spontaneously breathing rabbits, and their arterial blood pressure (ABP), blood leukocyte count and blood gases were observed for 2.5-3.5 h. Pulmonary vascular and airway function were subsequently evaluated in vitro by comparing weight changes, fluid ...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1993.tb03725.x

    authors: Opdahl H,Mollnes TE,Naess O

    更新日期:1993-05-01 00:00:00

  • Postoperative epidural infusion of morphine and bupivacaine is safe on surgical wards. Organisation of the treatment, effects and side-effects in 2000 consecutive patients.

    abstract:BACKGROUND:There was an obvious need to improve the quality and safety of our postoperative pain treatment and to introduce an improved routine service on surgical wards. METHODS:It was decided to use postoperative epidural infusion of morphine 0.04 mg/ml and bupivacaine 2.5 mg/ml (0.25%) 4-8 ml/h as pain relief after...

    journal_title:Acta anaesthesiologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1399-6576.1997.tb04802.x

    authors: Rygnestad T,Borchgrevink PC,Eide E

    更新日期:1997-08-01 00:00:00