Abstract:
:The anticancer effects of artesunate (ART) have been well documented. However, its potential against skin cancer has not been explored yet. Herein we reported that 60 μmol/l ART effectively inhibited A431 (human epidermoid carcinoma cells) growth but not that of HaCaT (normal human keratinocyte cells). Our results revealed that ART induced cell cycle arrest at G0/G1 phase through the downregulation of cyclin A1, cyclin B, cyclin D1, Cdk2, Cdk4, and Cdk6. This correlated with the upregulation of p21 and p27. The 5-bromodeoxyuridine incorporation assay also indicated that ART treatment reduced DNA synthesis in a time-dependent manner. Furthermore, ART induced mitochondrial apoptosis, as evidenced by annexin V/propidium iodide staining and western blot analysis. Interestingly, ART-induced apoptosis diminished under iron-deficient conditions but intensified under iron-overload conditions. Taken together, these findings demonstrated the potential of ART in treating skin cancer through the induction of G0/G1 cell cycle arrest and iron-mediated mitochondrial apoptosis and supported further investigations in other test systems.
journal_name
Anticancer Drugsjournal_title
Anti-cancer drugsauthors
Jiang Z,Chai J,Chuang HH,Li S,Wang T,Cheng Y,Chen W,Zhou Ddoi
10.1097/CAD.0b013e328350e8acsubject
Has Abstractpub_date
2012-07-01 00:00:00pages
606-13issue
6eissn
0959-4973issn
1473-5741journal_volume
23pub_type
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journal_title:Anti-cancer drugs
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