5-Fluorouracil accumulation in green microalgae and its biogenetic transfer into ciliate protozoan.

Abstract:

:The study has demonstrated that anticancer drug 5-fluorouracil causes acute toxicity and interferes with the growth of green microalgae, Scenedesmus vacuolatus. It accumulates in microalgae biomass with bioaccumulation factor of 1.84 × 10(4) and further integrates into the DNA and RNA of microalgae. In addition, the labelled microalgae genome is transferred into protozoan Tetrahymena pyriformis on feeding and is retained in the food vacuoles of predator organisms. This biotransfer of labelled 5-fluorouracil via genomic material was evaluated using radioactivity in Tetrahymena cell pellets though radioactivity did not detect anticancer drug in the genome of the predator organism.

authors

Ud-Daula A,Pfister G,Schramm KW

doi

10.1007/s00128-012-0536-8

subject

Has Abstract

pub_date

2012-04-01 00:00:00

pages

548-54

issue

4

eissn

0007-4861

issn

1432-0800

journal_volume

88

pub_type

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