Abstract:
:A decrease in the activity of choline acetyltransferase (ChAT) has been well documented in brains from individuals with Alzheimer's disease (AD) (Bird et al., 1983; McGeer, 1984). Decreased ChAT activity was also found in dialysis encephalopathy victims, but this reduction was less marked than that observed in AD (Yates et al., 1980). The involvement of aluminum in the etiology of AD has been proposed by some authors on the basis of abnormal concentration of aluminum in autopsied brain samples from AD patients (Krishnan et al., 1987), in the neurofibrillary tangles (Perl and Pendlebury, 1986) and the neuritic plaques (Candy et al., 1986). King (1984) hypothesized that elevated levels of aluminum contribute to the cholinergic deficits in AD. Aluminum is considered to be the causal factor in dialysis encephalopathy (Alfrey et al., 1976), particularly in young children with azotemia (Andreoli et al., 1984). Several animal studies demonstrate in vivo an aluminum effect on ChAT (Yates et al., 1980; Hofstetter et al., 1987). The distribution of the cholinergic perikarya in the rat CNS has been established immunohistochemically using antisera to ChAT (Sofroniev et al., 1982). From the basal forebrain, ChAT positive fiber bundles could be followed to the olfactory bulb, neocortex and hippocampus (Ichikawa and Hirata, 1986). This paper examines the influence of aluminum chloride at different concentrations on the activity of ChAT in homogenates from basal forebrain and neostriatum of rats during postnatal growth.
journal_name
Bull Environ Contam Toxicoljournal_title
Bulletin of environmental contamination and toxicologyauthors
Cherroret G,Desor D,Lehr PRdoi
10.1007/BF00194133subject
Has Abstractpub_date
1994-04-01 00:00:00pages
487-91issue
4eissn
0007-4861issn
1432-0800journal_volume
52pub_type
杂志文章abstract::The dissipation of cyprodinil under field and greenhouse condition in China was investigated. The pesticide cyprodinil dissipation differed under different cultivate conditions, the half lives were 14.5 and 12.5 days in strawberry and soil, respectively, under the field condition, 5.5 and 6.5 days, respectively, under...
journal_title:Bulletin of environmental contamination and toxicology
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journal_title:Bulletin of environmental contamination and toxicology
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abstract::Polycyclic aromatic hydrocarbons (PAHs) are of concern for both ecosystem and human health due to their potential teratogenic, carcinogenic, and mutagenic properties. The concentration of ∑16PAHs in foliar dust ranged from 49.4 to 19,018.1 µg kg-1, with a mean value of 7074.5 µg kg-1. There were significant seasonal v...
journal_title:Bulletin of environmental contamination and toxicology
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journal_title:Bulletin of environmental contamination and toxicology
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journal_title:Bulletin of environmental contamination and toxicology
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journal_title:Bulletin of environmental contamination and toxicology
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journal_title:Bulletin of environmental contamination and toxicology
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journal_title:Bulletin of environmental contamination and toxicology
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journal_title:Bulletin of environmental contamination and toxicology
pub_type: 杂志文章
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journal_title:Bulletin of environmental contamination and toxicology
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journal_title:Bulletin of environmental contamination and toxicology
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更新日期:2012-02-01 00:00:00
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journal_title:Bulletin of environmental contamination and toxicology
pub_type: 杂志文章
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更新日期:1979-08-01 00:00:00
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journal_title:Bulletin of environmental contamination and toxicology
pub_type: 已发布勘误
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journal_title:Bulletin of environmental contamination and toxicology
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journal_title:Bulletin of environmental contamination and toxicology
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更新日期:2010-09-01 00:00:00
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journal_title:Bulletin of environmental contamination and toxicology
pub_type: 杂志文章
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更新日期:2009-09-01 00:00:00
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journal_title:Bulletin of environmental contamination and toxicology
pub_type: 杂志文章
doi:10.1007/s00128-020-02917-7
更新日期:2020-08-01 00:00:00