Abstract:
:A new multicomponent domino reaction for rapid and regioselective synthesis of highly functionalized benzo[h]naphtho[2,3-a]acridine-15,16(5H,14H)-diones has been established. The reaction can be conducted by using readily available and inexpensive substrates under microwave irradiation. The procedures are facile, avoiding timeconsuming and costly syntheses, tedious work-up and purifications of precursors as well as protection/deprotection of functional groups. This method is much more efficient due to short reaction times and easy work up. The resulting naphthoacridines have been readily converted into benzoquinoxaline-fused benzoquinoline analogues by treating with benzene-1,2-diamine under microwave irradiation. The structural assignment has been ambiguously confirmed by X-ray analysis. A new mechanism has been proposed for this new multicomponent domino process.
journal_name
Comb Chem High Throughput Screenjournal_title
Combinatorial chemistry & high throughput screeningauthors
Wang SL,Zhang G,Jie D,Jiang B,Wang XH,Tu SJdoi
10.2174/138620712800194459subject
Has Abstractpub_date
2012-06-01 00:00:00pages
400-10issue
5eissn
1386-2073issn
1875-5402pii
CCHTS-EPUB-20120119-011journal_volume
15pub_type
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journal_title:Combinatorial chemistry & high throughput screening
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