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Identification and functional study of cytokines and chemokines involved in tumorigenesis.

Abstract：

:Tumorigenesis may be affected by various cellular components in the tumor cells and/or by tumor microenvironmental factors. Cytokines, including chemokines (chemotactic cytokines) are polypeptides or small soluble proteins generated by leukocytes and non-leukocytes, including cancer cells and stromal cells, for example, fibroblasts, mesenchymal stem cells (MSCs) and epithelial cells. Cytokines exert their functions on the cells that secrete them, on nearby cells, or on distant cells. Chemokines have expanded beyond their initial roles in impinging on every aspect of the immune system and leukocyte biology. They display multifunctional effects for regulating angiogenesis, tumor cell proliferation and apoptosis, mediating tumor cell metastasis in an organ-specific manner. This review will focus on the structural and functional aspects of chemokines as well as the roles that cytokines and their receptors play in angiogenesis, tumor invasion and metastasis, and discuss their potential value as important therapeutic targets for intervention in cancer.

journal_name

Comb Chem High Throughput Screen

journal_title

Combinatorial chemistry & high throughput screening

authors

Zeng J,Xie K,Wu H,Zhang B,Huang C

doi

10.2174/138620712799218608

subject

Has Abstract

pub_date

2012-03-01 00:00:00

pages

276-85

issue

3

eissn

1386-2073

issn

1875-5402

pii

BSP/CCHTS/E- Pub/0035

journal_volume

15

pub_type

杂志文章,评审

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