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Landiolol reduces coronary artery motion in an open-chest porcine model: implications for off-pump coronary artery bypass surgery.

Abstract：

:Reduction of target coronary artery motion is imperative for successful off-pump coronary artery bypass surgery. We hypothesized that landiolol, a novel ultra-short-acting selective β-1 blocker, would reduce such coronary artery motion. To test this hypothesis, the motion of the left anterior descending artery of the porcine heart (n = 8) was analyzed by three-dimensional digital motion capture and reconstruction technology with or without continuous landiolol infusion. Landiolol (0.12 mg/kg/min) significantly decreased the heart rate (105 ± 16 vs. 90 ± 9 beats/min), three-dimensional distance moved (-20.4% vs. control), maximum velocity (-30.0% vs. control), acceleration (-31.1% vs. control), and deceleration (-28.6% vs. control) without inducing a significant change in the systolic blood pressure (85 ± 18 vs. 81 ± 22 mmHg), cardiac output (4.3 ± 1.4 vs. 4.1 ± 1.3 l/min), or pulmonary wedge pressure (7.8 ± 3.0 vs. 8.7 ± 2.9 mmHg). Landiolol reduces the heart rate and coronary artery motion with stable hemodynamics, which may facilitate performing precise anastomosis on the beating heart.

journal_name

Surg Today

journal_title

Surgery today

authors

Wakamatsu H,Watanabe T,Sato Y,Takase S,Omata S,Yokoyama H

doi

10.1007/s00595-011-0047-y

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

205-8

issue

2

eissn

0941-1291

issn

1436-2813

journal_volume

42

pub_type

杂志文章

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