Prevention of neurodevelopmental sequelae of jaundice in the newborn.

Abstract:

:Although its cause, jaundice in the newborn, is extremely common, the disabling neurological disorder kernicterus is very rare. Kernicterus may be prevented by selecting those infants who are at risk of extreme jaundice or who may be particularly vulnerable to bilirubin neurotoxicity. Because the tools for achieving that goal are inadequate, a secondary strategy is needed. This involves a plan for emergency treatment of severely jaundiced infants, in particular those who present with neurological symptoms. In this paper I review the strategies for preventing extreme jaundice, and for reversing neurotoxicity in those infants for whom the principal strategies fail. Briefly, the tools for prevention include measurement of bilirubin while the infant is staying in the maternity unit, plotting the value on an hour-specific chart, assessing other risk factors for jaundice, and educating the parents. Emergency treatment should include immediate, high-irradiance phototherapy, consideration of intravenous immune globulin, and preparation for an exchange transfusion.

journal_name

Dev Med Child Neurol

authors

Hansen TW

doi

10.1111/j.1469-8749.2011.04059.x

subject

Has Abstract

pub_date

2011-09-01 00:00:00

pages

24-8

eissn

0012-1622

issn

1469-8749

journal_volume

53 Suppl 4

pub_type

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