Abstract:
:A series of N-(trifluoromethyl-2-pyridinyl)alkane- and arenesulfonamides 2-5 have been synthesized by the substitution reaction of 2-chloro(trifluoromethyl)pyridines 6 with alkane- and arenesulfonamides 7. Their inhibitory activities against secretory phospholipase A₂ of porcine pancreas were examined and the analog N-[4,5-bis(trifluoromethyl)-2-pyridinyl]-4-trifluoromethylbenzenesulfonamide 4i was shown to have the highest inhibitory activity, with an IC(50) value of 0.58 mM.
journal_name
Chem Pharm Bull (Tokyo)journal_title
Chemical & pharmaceutical bulletinauthors
Nakayama H,Morita Y,Kimura H,Ishihara K,Akiba S,Uenishi Jdoi
10.1248/cpb.59.783subject
Has Abstractpub_date
2011-01-01 00:00:00pages
783-6issue
6eissn
0009-2363issn
1347-5223pii
JST.JSTAGE/cpb/59.783journal_volume
59pub_type
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