Internal distribution of uranium and associated genotoxic damages in the chronically exposed bivalve Corbicula fluminea.

Abstract:

:Uranium (U) internal distribution and involved effects in the bivalve Corbicula fluminea have been studied after direct chronic exposure (90 d, 10 μg.L-1). U distribution was assessed at the subcellular level (Metal Rich Granules -MRG-, pellets and cytosol fractions) in two main organs of the bivalve (gills and visceral mass). Micro-localisation was investigated by TEM-EDX analysis in the gills epithelium. DNA damage in gill and hemolymph samples was measured by the Comet assay. The 90-d exposure period led to a significant increase of U concentration in gills over time (× 5) and a large U quantity in subcellular granules in gills. Finally, a significant increase (× 2) in DNA damage was noted in exposed gills and haemocytes. This study shows that the accumulation levels and consequently the potential toxicity cannot be successfully predicted only on the basis of concentration in water or in tissues and subcellular fractions after chronic exposure.

journal_name

J Environ Radioact

authors

Simon O,Floriani M,Cavalie I,Camilleri V,Adam C,Gilbin R,Garnier-Laplace J

doi

10.1016/j.jenvrad.2011.04.004

subject

Has Abstract

pub_date

2011-08-01 00:00:00

pages

766-73

issue

8

eissn

0265-931X

issn

1879-1700

pii

S0265-931X(11)00076-2

journal_volume

102

pub_type

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