Interstitial laser thermotherapy of a rat liver tumour: effect of hepatic inflow occlusion.

Abstract:

BACKGROUND AND OBJECTIVE:Interstitial laser thermotherapy was used to treat rat liver tumours. The aim was to investigate the influence of temperature and temporary hepatic inflow occlusion on tumour growth and blood perfusion. STUDY DESIGN/MATERIALS AND METHODS:Liver tumours were treated at 44°C at the tumour border for 30 minutes, hepatic inflow occlusion only, or a combination of these methods. Interstitial laser Doppler flowmetry was used to measure hepatic perfusion at the tumour border during and after heat treatment, for a total time of 60 minutes. Tumour growth was evaluated 6 days after treatment. RESULTS:Tumours subjected to the combined treatment of hepatic inflow occlusion and interstitial laser thermotherapy displayed a blood perfusion reduction 30 minutes after treatment to 18 ± 5% of initial perfusion, which was significantly lower than achieved with thermotherapy alone (52 ± 10%, P = 0.02). The combined treatment and treatment with thermotherapy alone resulted in relative tumour growth of 0.3 ± 0.1 and 1.0 ± 0.2, respectively (P = 0.04). CONCLUSION:Inflow occlusion enhanced the effect of thermotherapy not by augmenting treatment temperatures but by increasing the thermal sensitivity of the tumour, reflected by an immediate effect on tumour blood perfusion.

journal_name

Lasers Surg Med

authors

Sturesson C,Ivarsson K,Stenram U,Andersson-Engels S,Tranberg KG

doi

10.1002/lsm.21024

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

29-35

issue

1

eissn

0196-8092

issn

1096-9101

journal_volume

43

pub_type

杂志文章
  • Laser and suture anastomosis: passive compliance and active force production.

    abstract::One carotid from each dog underwent a laser anastomosis and the other carotid an interrupted suture repair. One or eight weeks later (n greater than or equal to 4 dogs/time period); four rings (1 mm in length) containing the laser or suture anastomosis or the normal artery (two/dog) were removed. Using a photoelectric...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章

    doi:10.1002/lsm.1900120213

    authors: Dalsing MC,Packer CS,Kueppers P,Griffith SL,Davis TE

    更新日期:1992-01-01 00:00:00

  • Intravascular ultrasound can be used to evaluate pulsed laser ablation of arterial tissue.

    abstract:BACKGROUND AND OBJECTIVE:Intravascular ultrasound (IVUS) has been used successfully to detect intravascular lesions. This study evaluates the ability of IVUS to detect acoustic damage to the arterial wall following high power, pulsed laser ablation. STUDY DESIGN/MATERIALS AND METHODS:Arterial ablation and disruption w...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章

    doi:10.1002/lsm.1900160205

    authors: Friedl SE,Mathews ED,Miyamoto A,Abela GS

    更新日期:1995-01-01 00:00:00

  • Effect of CO2 laser irradiation on experimental fracture healing: a transmission electron microscopic study.

    abstract::The healing of standardized fracture of rabbit radius was expedited as a result of treatment with low-power CO2 laser irradiation. Observation with transmission electron microscope revealed the following favorable effects of CO2 laser irradiation: The red blood cells were induced to disintegrate, thus promoting the ab...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章

    doi:10.1002/lsm.1900060309

    authors: Tang XM,Chai BP

    更新日期:1986-01-01 00:00:00

  • Progressive ascending telangiectasia treated with the 585 nm flashlamp-pumped pulsed dye laser.

    abstract:BACKGROUND AND OBJECTIVE:Progressive ascending telangiectasia (PAT) is a distinct entity with telangiectatic superficial vessels on lower extremities as its main clinical feature. A relationship with occult infections and response to antibiotic and antifungal drugs have been described, although not all cases can be suc...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-9101(1997)21:5<413::aid-lsm1>3.

    authors: Pérez B,Núñez M,Boixeda P,Harto A,Ledo A

    更新日期:1997-01-01 00:00:00

  • Tooth caries detection by curve fitting of laser-induced fluorescence emission: a comparative evaluation with reflectance spectroscopy.

    abstract:BACKGROUND AND OBJECTIVES:Nitrogen laser-induced fluorescence (LIF) spectra of sound tooth consists of two broad bands centered at 440 and 490 nm, with two apparent side bands on either side. In order to locate the exact peak position of these bands and to effectively utilize the LIF spectral signatures for detection o...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章

    doi:10.1002/lsm.20229

    authors: Subhash N,Thomas SS,Mallia RJ,Jose M

    更新日期:2005-10-01 00:00:00

  • Intradermally focused infrared laser pulses: thermal effects at defined tissue depths.

    abstract:BACKGROUND AND OBJECTIVES:To produce controlled, spatially confined thermal effects in dermis. STUDY DESIGNS/MATERIALS AND METHODS:A 1 W, 1,500 nm fiber-coupled diode laser was focused with a high numerical aperture (NA) objective to achieve a tight optical focus within the upper dermis of skin held in contact with a ...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章

    doi:10.1002/lsm.20142

    authors: Khan MH,Sink RK,Manstein D,Eimerl D,Anderson RR

    更新日期:2005-04-01 00:00:00

  • Optically mediated nerve stimulation: Identification of injury thresholds.

    abstract:BACKGROUND AND OBJECTIVE:Transient optical nerve stimulation is a promising new non-contact, spatially precise, artifact-free neural excitation technique useful in research and clinical settings. This study evaluates safety of this pulsed infrared laser technique by histopathologic examination of stimulated peripheral ...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章

    doi:10.1002/lsm.20522

    authors: Wells JD,Thomsen S,Whitaker P,Jansen ED,Kao CC,Konrad PE,Mahadevan-Jansen A

    更新日期:2007-07-01 00:00:00

  • Pc 4 photodynamic therapy of U87-derived human glioma in the nude rat.

    abstract:BACKGROUND AND OBJECTIVES:As a potential therapy for malignant glioma, we tested the phthalocyanine photosensitizer Pc 4 for: (1) rapid clearance from the vasculature, (2) specificity for glioma, and (3) tumoricidal photosensitizing capability. STUDY DESIGN/MATERIALS AND METHODS:Parenchymal injection of U87 cells into...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章

    doi:10.1002/lsm.20185

    authors: George JE 3rd,Ahmad Y,Varghai D,Li X,Berlin J,Jackowe D,Jungermann M,Wolfe MS,Lilge L,Totonchi A,Morris RL,Peterson A,Lust WD,Kenney ME,Hoppel CL,Sun J,Oleinick NL,Dean D

    更新日期:2005-06-01 00:00:00

  • Protoporphyrin IX fluorescence and photobleaching during interstitial photodynamic therapy of malignant gliomas for early treatment prognosis.

    abstract:BACKGROUND AND OBJECTIVE:Interstitial photodynamic therapy (iPDT) of non-resectable recurrent glioblastoma using 5-aminolevulinic acid (ALA)-induced protoporphyrin IX (PpIX) has shown a promising outcome. It remained unclear, however, to what extent inter- and intra-tumoural differences of PpIX concentrations influence...

    journal_title:Lasers in surgery and medicine

    pub_type: 临床试验,杂志文章

    doi:10.1002/lsm.22126

    authors: Johansson A,Faber F,Kniebühler G,Stepp H,Sroka R,Egensperger R,Beyer W,Kreth FW

    更新日期:2013-04-01 00:00:00

  • Effect of low-level laser therapy (LLLT) on viscoelasticity of the contracted knee joint: comparison with whirlpool treatment in rats.

    abstract:BACKGROUND AND OBJECTIVE:The purpose of this study was to compare the effect of Low-Level Laser Therapy (LLLT) with sham and whirlpool treatment on the contracted knee joint in rat. STUDY DESIGN/MATERIALS AND METHODS:Forty-eight Wistar rats were operated on to immobilize knee joint, and 1 week after operation they wer...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-9101(1998)22:2<81::aid-lsm3>3.0

    authors: Usuba M,Akai M,Shirasaki Y

    更新日期:1998-01-01 00:00:00

  • A multispectral fluorescence imaging system: design and initial clinical tests in intra-operative Photofrin-photodynamic therapy of brain tumors.

    abstract:BACKGROUND AND OBJECTIVES:Intra-operative identification of tumor by fluorescence may improve surgical resection or photodynamic therapy (PDT). A novel instrument was designed, constructed, and tested for this purpose. STUDY DESIGN/MATERIALS AND METHODS:The instrument was designed to provide high-resolution, multi-spe...

    journal_title:Lasers in surgery and medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/lsm.10131

    authors: Yang VX,Muller PJ,Herman P,Wilson BC

    更新日期:2003-01-01 00:00:00

  • Laser revascularization, 1985: state of the art.

    abstract::Progress in the young field of laser recanalization of occluded arteries and applications in cardiovascular disease to which many investigators have contributed is briefly summarized. Specific problems remaining to be solved are set forth. In conclusion, the author makes a cautious prediction of success for the percut...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章

    doi:10.1002/lsm.1900060412

    authors: Choy DS

    更新日期:1986-01-01 00:00:00

  • Cornea epithelial damage thresholds in rabbits exposed to Tm:YAG laser radiation at 2.02 microns.

    abstract::We have determined exposure conditions for minimal damage to the corneal epithelium in rabbit using a continuous wave Tm: YAG laser operating in the TEM00 mode at incident powers between 80 and 450 mW. The 1/e beam diameter was 0.94 mm and exposure durations for threshold damage ranged from 4.3 to 0.08 sec. Calculated...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章

    doi:10.1002/lsm.1900120605

    authors: McCally RL,Farrell RA,Bargeron CB

    更新日期:1992-01-01 00:00:00

  • Fractional CO2 laser resurfacing for atrophic acne scars: a randomized controlled trial with blinded response evaluation.

    abstract:BACKGROUND:The treatment of acne scars with fractional CO(2) lasers is gaining increasing impact, but has so far not been compared side-by-side to untreated control skin. OBJECTIVE:In a randomized controlled study to examine efficacy and adverse effects of fractional CO(2) laser resurfacing for atrophic acne scars com...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/lsm.22048

    authors: Hedelund L,Haak CS,Togsverd-Bo K,Bogh MK,Bjerring P,Haedersdal M

    更新日期:2012-08-01 00:00:00

  • Effects of early combinatorial treatment of autologous split-thickness skin grafts in red duroc pig model using pulsed dye laser and fractional CO2 laser.

    abstract:BACKGROUND AND OBJECTIVE:The use of pulsed dye laser (PDL) and fractional CO2 (FX CO2 ) laser therapy to treat and/or prevent scarring following burn injury is becoming more widespread with a number of studies reporting reduction in scar erythema and pruritus following treatment with lasers. While the majority of studi...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章

    doi:10.1002/lsm.22702

    authors: Bailey JK,Blackstone BN,DeBruler DM,Kim JY,Baumann ME,McFarland KL,Imeokparia FO,Supp DM,Powell HM

    更新日期:2018-01-01 00:00:00

  • Histologic changes associated with talaporfin sodium-mediated photodynamic therapy in rat skin.

    abstract:BACKGROUND AND OBJECTIVE:Alternative treatments are needed to achieve consistent and more complete port wine stain (PWS) removal, especially in darker skin types; photodynamic therapy (PDT) is a promising alternative treatment. To this end, we previously reported on Talaporfin Sodium (TS)-mediated PDT. It is essential ...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章

    doi:10.1002/lsm.22677

    authors: Moy WJ,Yao J,de Feraudy SM,White SM,Salvador J,Kelly KM,Choi B

    更新日期:2017-10-01 00:00:00

  • Outcomes of Two Treatments for Uncomplicated Pilonidal Sinus Disease: Karydakis Flap Procedure and Sinus Tract Ablation Procedure Using a 1,470 nm Diode Laser Combined With Pit Excision.

    abstract:BACKGROUND AND OBJECTIVES:An ideal treatment for pilonidal disease should feature a low recurrence rate, minimal incision, and rapid return to daily activities. We compared the outcomes of the well-defined Karydakis technique (KT) and a combination of pit excision (PE) and sinus tract ablation using 1,470-nm diode lase...

    journal_title:Lasers in surgery and medicine

    pub_type:

    doi:10.1002/lsm.23224

    authors: Yardimci VH

    更新日期:2020-11-01 00:00:00

  • Improved staining method for determining the extent of thermal damage to cells.

    abstract:BACKGROUND AND OBJECTIVE:Enzyme histochemical stains of frozen sections have been used by investigators to assess thermal damage. The assessment of thermal damage to cells in lipid-rich tissues such as subcutaneous tissue and sebaceous glands can be difficult due to the quality of frozen sections of such tissues. The p...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章

    doi:10.1002/lsm.20450

    authors: Sherwood ME,Flotte TJ

    更新日期:2007-02-01 00:00:00

  • Copper bromide laser treatment of facial telangiectasia: results of patients treated over five years.

    abstract:BACKGROUND AND OBJECTIVE:Various yellow light lasers have been used over the past decade in an attempt to eradicate facial telangiectasia. Based on their power output, spot size, and pulsing characteristics, these lasers belong to one of two categories that exist at either end of a spectrum--high power, short pulse, an...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-9101(1997)21:4<329::aid-lsm4>3.

    authors: McCoy SE

    更新日期:1997-01-01 00:00:00

  • Optimizing light dosimetry in photodynamic therapy of early stage carcinomas of the esophagus using fluorescence spectroscopy.

    abstract:BACKGROUND AND OBJECTIVE:Under standardized conditions (drug and light dose, timing), the result of the photodynamic therapy (PDT) of carcinomas of the esophagus with tetra(meta-hydroxyphenyl)chlorin (mTHPC) shows large variations between patients. STUDY DESIGN/MATERIALS AND METHODS:Before patients underwent PDT treat...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章

    doi:10.1002/(SICI)1096-9101(1996)19:3<340::AID-LSM10>3

    authors: Braichotte DR,Savary JF,Monnier P,van den Bergh HE

    更新日期:1996-01-01 00:00:00

  • Pixel CO2 Laser for the Treatment of Stress Urinary Incontinence: A Prospective Observational Multicenter Study.

    abstract:BACKGROUND AND OBJECTIVES:Energy-based treatments have been found to be a promising treatment modality for improving stress urinary incontinence (SUI) symptoms. This prospective two-center study was designed to evaluate the efficacy of fractional-pixel CO2 laser for the treatment of SUI. STUDY DESIGN/MATERIALS AND MET...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章

    doi:10.1002/lsm.23319

    authors: Franić D,Fistonić I,Franić-Ivanišević M,Perdija Ž,Križmarić M

    更新日期:2020-09-08 00:00:00

  • Resection of abdominal hollow organs by laser.

    abstract::During a ten-year period 642 abdominal hollow organ resections have been performed by means of a new, original technique--that is, CO2 laser irradiation combined with specially designed instrumentation. This resulted in a remarkable decrease in postoperative morbidity and mortality. The article describes the laser pro...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章

    doi:10.1002/lsm.1900070402

    authors: Skobelkin OK,Breckov EI,Bashilov VP,Korepanov VI,Litwin GD,Smoljaninov MV,Malyshev BN,Salyuk VA

    更新日期:1987-01-01 00:00:00

  • Treatment of atrophic acne scarring with fractional micro-plasma radio-frequency in Chinese patients: A prospective study.

    abstract:BACKGROUND:Acne scarring is a common disfiguring sequela of acne vulgaris which can lead to serious psychosocial problems and have a negative effect on patients' quality of life. Although a variety of approaches can be used to treat atrophic acne scars, disadvantages such as long-healing time, dyspigmentation, infectio...

    journal_title:Lasers in surgery and medicine

    pub_type: 临床试验,杂志文章

    doi:10.1002/lsm.22825

    authors: Lan T,Xiao Y,Tang L,Hamblin MR,Yin R

    更新日期:2018-10-01 00:00:00

  • Prospective study of cutaneous phototoxicity after systemic hematoporphyrin derivative.

    abstract::Hematoporphyrin derivative (HpD) is a photoactive, oncophilic substance that produces cutaneous photosensitivity as its only significant side effect. Twenty-three patients who received systemic HpD and the usual light-avoidance precautions were studied prospectively to determine the incidence and severity of cutaneous...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章

    doi:10.1002/lsm.1900080312

    authors: Wooten RS,Smith KC,Ahlquist DA,Muller SA,Balm RK

    更新日期:1988-01-01 00:00:00

  • Beneficial effects of early treatment of infantile hemangiomas with a long-pulse Alexandrite laser.

    abstract:BACKGROUND AND OBJECTIVE:There is an increasing interest in treating vascular lesions with a long-pulse Alexandrite laser. However, it is difficult to search information in the literature about infantile hemangiomas (IH) treated with long-pulse Alexandrite laser. This article aims to determine whether 755 nm long-pulse...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章

    doi:10.1002/lsm.22221

    authors: Su W,Ke Y,Xue J

    更新日期:2014-03-01 00:00:00

  • Fine structure of zonal changes in experimental Nd:YAG laser-induced interstitial hyperthermia.

    abstract::Interstitial thermotherapy using Nd:YAG-laser induced hyperthermia is a new stereotactic method for the treatment of brain tumors in poorly accessible regions. To provide a basis for the underlying tissue alterations, we have analyzed the spatial and temporal pattern of interstitial laser hyperthermia lesions in the n...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章

    doi:10.1002/lsm.1900130212

    authors: Schober R,Bettag M,Sabel M,Ulrich F,Hessel S

    更新日期:1993-01-01 00:00:00

  • Fractionated bipolar radiofrequency and bipolar radiofrequency potentiated by infrared light for treating striae: A prospective randomized, comparative trial with objective evaluation.

    abstract:BACKGROUND AND OBJECTIVE:Very few treatments for striae are based on prospective randomized trials. The objective of this study was to assess the efficacy of bipolar fractional radiofrequency and bipolar radiofrequency potentiated with infrared light, alone or combined, for treating abdominal stretch marks. STUDY DESI...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1002/lsm.22458

    authors: Harmelin Y,Boineau D,Cardot-Leccia N,Fontas E,Bahadoran P,Becker AL,Montaudié H,Castela E,Perrin C,Lacour JP,Passeron T

    更新日期:2016-03-01 00:00:00

  • Laser thermal angioplasty probe ("hot tip") temperature: effects of flow.

    abstract::The temperature developed by the laser thermal ("hot tip") probe during arterial recanalisation is primarily dependent on the rate of energy delivery and the rate of dissipation to the surrounding medium. While higher probe tip temperatures enhance the efficacy of atheroma ablation, so too is the incidence of adverse ...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章

    doi:10.1002/lsm.1900100204

    authors: Rosenthal E,Foussas S,Montarello JK,Boyd EG,Curry PV

    更新日期:1990-01-01 00:00:00

  • Human liver autofluorescence: an intrinsic tissue parameter discriminating normal and diseased conditions.

    abstract:BACKGROUND AND OBJECTIVE:Autofluorescence (AF) emission is an intrinsic parameter that can provide real-time information on morpho-functional properties of biological tissue, being strictly related with their biochemical composition and structural organization. The diagnostic potentials of AF-based techniques have been...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章

    doi:10.1002/lsm.20923

    authors: Croce AC,De Simone U,Freitas I,Boncompagni E,Neri D,Cillo U,Bottiroli G

    更新日期:2010-07-01 00:00:00

  • Low level laser therapy for the management of breast cancer-related lymphedema: A randomized controlled feasibility study.

    abstract:OBJECTIVES:This study aimed to determine the feasibility of conducting a full scale randomized controlled trial investigating the effectiveness of low level laser therapy (LLLT), also known as photobiomodulation (PBM) therapy, used in addition to conventional therapy, for managing breast cancer related lymphedema (BCRL...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/lsm.22947

    authors: Baxter GD,Liu L,Tumilty S,Petrich S,Chapple C,Anders JJ,Laser Lymphedema Trial Team.

    更新日期:2018-09-01 00:00:00