[Relation between selenium plasma levels and different prostatic pathologies].

Abstract:

UNLABELLED:Several studies have demonstrated an inverse relation between serum selenium levels (Se) and advanced prostate cancer (PCa). OBJECTIVE:To determine and compare selenium plasma levels in patients with different prostatic pathologies. MATERIAL AND METHODS:It is a transversal, descriptive and comparative study. A sample of 64 men between 50 and 80 years old were selected for the study between 2007 and 2009. All volunteers underwent a digital rectal examination, prostate specific antigen level, ultrasound and transrectal prostate biopsy (12-14 chips). Prostate cancer was subclassified according to Gleason Score. Selenium was determined indirectly by serum Glutathione peroxidase (Kit Ransel, Randox SRL, Crumlin, UK). Statistical analysis was performed using ANOVA I (p<0.05). RESULTS:Glutathione Peroxidase level was 33.75+/-2.36 mg/ml in control patients. A decrease of 31.6% was observed in patients with BPH (23.08+/-1.57 mg/ml) and of (63.6%) in subjects with prostate cancer (12.28+/-1.03 mg/ml) (p<0,0001). There was no correlation with the Gleason Score. CONCLUSION:Serum Seleniun is lower in patients with prostatic pathologies being even more important in cancer patients regardless the Gleason Score.

journal_name

Actas Urol Esp

authors

López Fontana CM,Pérez Elizalde RF,Vanrell MC,Recalde GM,Uvilla AL,López Laur JD

subject

Has Abstract

pub_date

2010-07-01 00:00:00

pages

625-9

issue

7

eissn

0210-4806

issn

1699-7980

pii

13151520

journal_volume

34

pub_type

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