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Synthesis and anti-mycobacterial evaluation of some pyrazine-2-carboxylic acid hydrazide derivatives.

Abstract：

:A series of pyrazine-2-carboxylic acid hydrazide derivatives were synthesized and screened for their activity against Mycobacterium tuberculosis. The results show that pyrazine-2-carboxylic acid hydrazide-hydrazone derivatives 3a-l were less active than pyrazinamide. In contrast, the N(4)-ethyl-N(1)-pyrazinoyl-thiosemicarbazide 4 showed the highest activity against M. tuberculosis H(37)Rv (IC(90) = 16.87 microg/mL). Details of the structure-activity and structure-cytotoxicity relationships are discussed.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Abdel-Aziz M,Abdel-Rahman HM

doi

10.1016/j.ejmech.2010.04.025

subject

Has Abstract

pub_date

2010-08-01 00:00:00

pages

3384-8

issue

8

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(10)00307-7

journal_volume

45

pub_type

杂志文章

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