Abstract：
:Published data on the association between Xeroderma Pigmentosum complementation group D (XPD) Lys751Gln polymorphism and breast cancer risk are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. Crude ORs with 95% CIs were used to assess the strength of association between them. A total of 30 studies including 14,283 cases and 14,426 controls were involved in this meta-analysis. Overall, significantly elevated breast cancer risk was associated with XPD 751Gln allele when all studies were pooled into the meta-analysis (Lys/Gln vs. Lys/Lys: OR = 1.13, 95% CI = 1.02-1.25; Gln/Gln vs. Lys/Lys: OR = 1.21, 95% CI = 1.06-1.38; dominant model: OR = 1.16, 95% CI = 1.05-1.29; and recessive model: OR = 1.14, 95% CI = 1.02-1.27). In the subgroup analysis by ethnicity, borderline significantly increased risks were found for Caucasians (Lys/Gln vs. Lys/Lys: OR = 1.09, 95% CI = 0.98-1.22; dominant model: OR = 1.10, 95% CI = 0.99-1.22) and significantly increased risks were found for Africans in dominant model (OR = 1.10, 95% CI = 1.04-1.15). When stratified by study design, statistically significantly elevated risk was found in population-based studies (Lys/Gln vs. Lys/Lys: OR = 1.10, 95% CI = 1.01-1.20; Gln/Gln vs. Lys/Lys: OR = 1.15, 95% CI = 1.01-1.31; dominant model: OR = 1.12, 95% CI = 1.03-1.23). In conclusion, this meta-analysis suggests that the XPD 751Gln allele is a low-penetrant risk factor for developing breast cancer.
journal_name
Breast Cancer Res Treatjournal_title
Breast cancer research and treatmentauthors
Qiu LX,Yao L,Zhang J,Zhu XD,Zhao XM,Xue K,Mao C,Chen B,Zhan P,Yuan H,Hu XCdoi
10.1007/s10549-010-0813-3subject
Has Abstractpub_date
2010-11-01 00:00:00pages
229-35issue
1eissn
0167-6806issn
1573-7217journal_volume
124pub_type
杂志文章,meta分析abstract：:Axillary evaluation in women with ductal carcinoma in situ (DCIS) is increasing; however, this may introduce additional morbidity with unclear benefit. Our objective was to examine the morbidity and mortality associated with axillary evaluation in DCIS. We conducted a retrospective cohort study of 10,504 women aged 65...
journal_title：Breast cancer research and treatment
pub_type： 杂志文章
doi：10.1007/s10549-016-3890-0
更新日期：2016-07-01 00:00:00
abstract：PURPOSE:The ER-/PR-/HER2- or triple-negative (TNBC) subtype is more prevalent among women who are young, black, Hispanic, and of lower SES. The purpose of this study is to determine if young age and low SES are associated with TNBC within four mutually exclusive race/ethnicities. METHODS:The study identified 19,283 ca...
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pub_type： 杂志文章
doi：10.1007/s10549-017-4159-y
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journal_title：Breast cancer research and treatment
pub_type： 杂志文章
doi：10.1007/s10549-012-2240-0
更新日期：2012-11-01 00:00:00
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journal_title：Breast cancer research and treatment
pub_type： 临床试验,杂志文章
doi：10.1007/BF01833358
更新日期：1991-12-01 00:00:00
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journal_title：Breast cancer research and treatment
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doi：10.1007/s10549-004-2128-8
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journal_title：Breast cancer research and treatment
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doi：10.1007/s10549-010-1016-7
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journal_title：Breast cancer research and treatment
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journal_title：Breast cancer research and treatment
pub_type： 杂志文章
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journal_title：Breast cancer research and treatment
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journal_title：Breast cancer research and treatment
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journal_title：Breast cancer research and treatment
pub_type： 临床试验,杂志文章
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journal_title：Breast cancer research and treatment
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journal_title：Breast cancer research and treatment
pub_type： 杂志文章
doi：10.1007/BF00694750
更新日期：1995-07-01 00:00:00
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journal_title：Breast cancer research and treatment
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更新日期：2005-11-01 00:00:00
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journal_title：Breast cancer research and treatment
pub_type： 杂志文章
doi：10.1007/s10549-011-1413-6
更新日期：2011-05-01 00:00:00
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journal_title：Breast cancer research and treatment
pub_type： 杂志文章
doi：10.1007/s10549-008-0108-0
更新日期：2009-07-01 00:00:00
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journal_title：Breast cancer research and treatment
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doi：10.1023/a:1012564620853
更新日期：2001-11-01 00:00:00
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journal_title：Breast cancer research and treatment
pub_type： 杂志文章
doi：10.1007/s10549-008-9992-6
更新日期：2009-03-01 00:00:00
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journal_title：Breast cancer research and treatment
pub_type： 杂志文章
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更新日期：2011-02-01 00:00:00
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journal_title：Breast cancer research and treatment
pub_type： 杂志文章
doi：10.1007/BF01980969
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journal_title：Breast cancer research and treatment
pub_type： 杂志文章
doi：10.1007/BF01807283
更新日期：1988-07-01 00:00:00
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journal_title：Breast cancer research and treatment
pub_type： 杂志文章
doi：10.1007/BF00666176
更新日期：1994-01-01 00:00:00
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journal_title：Breast cancer research and treatment
pub_type： 杂志文章
doi：10.1023/a:1014405730585
更新日期：2002-02-01 00:00:00
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journal_title：Breast cancer research and treatment
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journal_title：Breast cancer research and treatment
pub_type： 杂志文章
doi：10.1007/BF01806367
更新日期：1991-01-01 00:00:00
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journal_title：Breast cancer research and treatment
pub_type： 杂志文章
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更新日期：2016-11-01 00:00:00
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journal_title：Breast cancer research and treatment
pub_type： 杂志文章,多中心研究,随机对照试验
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更新日期：2014-02-01 00:00:00
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journal_title：Breast cancer research and treatment
pub_type： 杂志文章
doi：10.1007/s10549-016-3729-8
更新日期：2016-02-01 00:00:00
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journal_title：Breast cancer research and treatment
pub_type： 杂志文章
doi：10.1007/s10549-006-9292-y
更新日期：2007-03-01 00:00:00
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journal_title：Breast cancer research and treatment
pub_type： 临床试验,杂志文章
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更新日期：2013-10-01 00:00:00
