Supplementation of fat grafts with adipose-derived regenerative cells improves long-term graft retention.

Abstract:

:Current practice of autologous fat transfer for soft tissue augmentation is limited by poor long-term graft retention. Adipose-derived regenerative cells (ADRCs) contain several types of stem and regenerative cells, which may help improve graft retention through multiple mechanisms. Using a murine fat transplantation model, ADRCs were added to transplanted fat to test whether ADRCs could improve the long-term retention of the grafts. This study showed, at both 6 and 9 months after transplantation, ADRCs not only increased graft retention by 2-fold but also improved the quality of the grafts. ADRC-supplemented grafts had a higher capillary density, indicating ADRCs could promote neovascularization. Further cell tracking and gene expression studies suggest ADRCs may promote angiogenesis and adipocyte differentiation and prevent apoptosis through the expression of various growth factors, including VEGFA and IGF-1. Taken together, these results suggest a potential clinical utility of ADRCs in facilitating autologous fat transfer for soft tissue augmentation.

journal_name

Ann Plast Surg

authors

Zhu M,Zhou Z,Chen Y,Schreiber R,Ransom JT,Fraser JK,Hedrick MH,Pinkernell K,Kuo HC

doi

10.1097/SAP.0b013e31819ae05c

subject

Has Abstract

pub_date

2010-02-01 00:00:00

pages

222-8

issue

2

eissn

0148-7043

issn

1536-3708

pii

00000637-201002000-00025

journal_volume

64

pub_type

杂志文章
  • Mycobacterium avium infection in a patient with acquired immunodeficiency syndrome and a solid silicone buttock implant.

    abstract::A 31-year-old female patient with both acquired immunodeficiency syndrome and a solid silicone buttock implant presented with fever. Using ultrasound-guided aspiration of the periprosthetic space, a diagnosis of Mycobacterium avium complex infection involving the implant was made. The implant was surgically removed an...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/00000637-199610000-00011

    authors: Kaplan A,Orsetti KE,Kuzon WM Jr

    更新日期:1996-10-01 00:00:00

  • Assessing third-year medical students' knowledge of and exposure to cleft palate before and after plastic surgery rotation.

    abstract::The purpose of this study was to evaluate third-year medical students' knowledge of and exposure to cleft palate before and after a rotation in plastic surgery. A 26-item questionnaire was administered to 37 students before and after their 12-week rotation that included the evaluation and management of patients with c...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/00000637-199604000-00009

    authors: Vallino LD,Brown AS

    更新日期:1996-04-01 00:00:00

  • Small intestinal submucosa: utilization for repair of rodent abdominal wall defects.

    abstract::Prosthetic graft material is often used for the repair of abdominal wall defects that result from trauma, infection, neoplastic, or congenital deformities. A new material, porcine small intestinal submucosa, has been successfully used as an arterial and venous graft material in both canine and primate animal models wi...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:

    authors: Prevel CD,Eppley BL,Summerlin DJ,Jackson JR,McCarty M,Badylak SF

    更新日期:1995-10-01 00:00:00

  • Postauricular Approach for Mandibular Angle Ostectomy: An Alternative for Shortening the Recovery Time.

    abstract::Many surgical procedures to improve mandibular contour have been introduced in East Asia. Despite consensus regarding mandible contouring surgery, surgery which includes angle ostectomy and lateral cortex excision, some patients require only mandibular angle ostectomy. The intraoral approach is a widely used method, b...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/SAP.0000000000000216

    authors: Lim H,Kang M

    更新日期:2016-01-01 00:00:00

  • Beckwith-Wiedemann syndrome and juvenile fibroadenoma: a case report.

    abstract::Beckwith-Wiedemann syndrome (BWS) is a complex overgrowth disorder usually recognized at birth. Children diagnosed with BWS, particularly those with hemihypertrophy, experience an increased risk of developing benign and malignant tumors. This case report presents a 12-year-old girl with BWS and hemihypertrophy who rap...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章,评审

    doi:10.1097/sap.0b013e3181b025f6

    authors: Poh MM,Ballard TN,Wendel JJ

    更新日期:2010-06-01 00:00:00

  • L-Shaped Lipothighplasty.

    abstract:BACKGROUND:In addition to the already-known postoperative complications in patients formerly obese, for medial thigh lift, there are many more problematic issues. The main ones are represented as follows: by the frequent downward displacement of the scars that become, in this way, extremely visible; by the distortion o...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/SAP.0000000000000075

    authors: Bracaglia R,Tambasco D,Gentileschi S,D'Ettorre M

    更新日期:2015-09-01 00:00:00

  • Extended preseptal fat resection in Asian blepharoplasty.

    abstract::The thickness of the upper eyelid is a bothersome condition that can be alleviated by blepharoplasty in Asians. Preseptal fat lies widely deep to the orbicularis oculi in the lower part of the upper eyelid, and the retro-orbicularis oculus fat (ROOF) pad lies in the lateral supraorbital area. We demonstrate the effect...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/01.sap.0000263094.74682.5f

    authors: Ichinose A,Tahara S

    更新日期:2008-02-01 00:00:00

  • Translocation of the fifth finger by intracarpal osteotomy.

    abstract::We present an original technique of transposition of the fifth ray by intracarpal osteotomy. After a review of various techniques and their disadvantages, the principles of the procedure are described. It includes a resection of the whole fourth ray and translocation of the fifth ray following a wedge-shaped osteotomy...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/00000637-198609000-00009

    authors: Le Viet D

    更新日期:1986-09-01 00:00:00

  • A reverse triangular soleus flap based on small distal communicating arterial branches.

    abstract::We report a 25-year-old woman who suffered traumatic damage to the medial malleolar area. Arteriography revealed a posterior tibial artery occlusion at the ankle. The predominant pattern of medial soleus vascularization was revealed during surgery. A reverse medial soleus flap including the posterior tibial pedicle wa...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/00000637-199810000-00018

    authors: Dumont CE,Masquelet AC

    更新日期:1998-10-01 00:00:00

  • The Protective Effects of Botulinum Toxin A Against Flap Necrosis After Perforator Twisting and Its Underlying Molecular Mechanism in a Rat Model.

    abstract:PURPOSE:The purpose of this study was to examine our hypotheses that botulinum toxin A (BoTA) protect necrosis of perforator flap from perforator twisting. METHODS:Twenty-four rats were randomly divided into 2 groups. Twelve International Units of BoTA versus 1.2 mL normal saline was injected subdermally 3 days before...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/SAP.0000000000000563

    authors: Kim SY,Lee SH,Lee B,Park YJ,Park JH,Lee YS,Rah DK,Park TH

    更新日期:2016-08-01 00:00:00

  • Ptosis Sensitivity Threshold for the Lay Observer.

    abstract:PURPOSE:This study aims to understand the degree to which ptosis is recognizable to a layperson. METHODS:Fifteen color drawings of a gender-neutral human face were created. Six faces exhibited right-sided ptosis (decreased margin reflex distance 1 and lengthened tarsal platform show) of 0.5 mm, 1 mm, 1.5 mm, 2 mm, 2.5...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/SAP.0000000000001524

    authors: Gordon MJ,Christenbury JG,Bokman CL,Rootman DB,Goldberg RA

    更新日期:2018-09-01 00:00:00

  • Perioperative Use of Antiestrogen Therapies in Breast Reconstruction: A Systematic Review and Treatment Recommendations.

    abstract:BACKGROUND:Patients with hormone receptor-positive breast tumors receive hormonal therapy with either selective estrogen receptor modulators (SERMs) (eg, tamoxifen) or aromatase inhibitors (AIs) (eg, anastrozole) for 5 to 10 years. Patients are using these therapies frequently during breast reconstruction. Literature i...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/SAP.0000000000002394

    authors: Spera LJ,Cook JA,Dolejs S,Fisher C,Lester ME,Hassanein AH

    更新日期:2020-10-01 00:00:00

  • Histological changes of the voice tube and possible clinical consequences after voice reconstruction with free ileocolon flap.

    abstract::Free ileocolon flap has become a valid option for restoration of speech after pharyngolaryngectomy. After transfer, deprivation of the trophic intestinal contents and exposure to chronic intermittent airflow could substantially modify the structure of the voice tube, compromising its function. Biopsy specimens from 14...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/SAP.0b013e31824680a9

    authors: Gharb BB,Rampazzo A,Hsu CT,Bassetto F,Spanio di Spilimbergo S,Chen HC

    更新日期:2013-07-01 00:00:00

  • The hemostatic effect of conjugated water-soluble estrogens in rats.

    abstract::Estrogenic steroids have been used as hemostatic agents in various surgical procedures in humans. Their use to reduce bleeding has been based mainly on clinical observation. The present study was carried out to test experimentally whether intravenously administered Premarin reduces capillary bleeding. Skin-graft donor...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/00000637-198205000-00005

    authors: Tsur H,Rasner C,Shafir R,Sampson S

    更新日期:1982-05-01 00:00:00

  • Immediate reconstruction of oncologic hemipelvectomy defects.

    abstract:BACKGROUND:Soft tissue and bony tumors of the pelvis are rare, but when they occur, treatment presents both an oncologic surgical and a reconstructive challenge. After reconstruction, soft tissue defects can be large and there is usually exposed bone and/or joint. A retroperitoneal abdominal wall defect may also be pre...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/01.sap.0000215288.83924.6c

    authors: Knox K,Bitzos I,Granick M,Datiashvili R,Benevenia J,Patterson F

    更新日期:2006-08-01 00:00:00

  • Abdominal contouring in super obese patients: a single-surgeon review of 22 cases.

    abstract:BACKGROUND:It is generally believed that increasing obesity is a predictor of postoperative complications after abdominal contouring procedures such as abdominoplasty and panniculectomy. The purpose of this study is to review the complication rate for abdominal contouring in the level 3 obesity category (body mass inde...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/SAP.0b013e3182012580

    authors: Mericli AF,Drake DB

    更新日期:2011-05-01 00:00:00

  • Successful Treatment of Plantar Hyperkeratosis in the Form of Recurrent Corns With Split-Thickness Sole Skin Graft.

    abstract:INTRODUCTION:Plantar hyperkeratosis, such as corns and calluses, is common in older people and associated with pain, mobility impairment, and functional limitations. It usually develops on the palms, knees, or soles of feet, especially under the heels or balls. There are several treatment methods for plantar hyperkerat...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/SAP.0000000000001304

    authors: Wang CY,Chang CK,Chou CY,Wu CJ,Chu TS,Chiao HY,Chen CY,Chen TM,Tzeng YS

    更新日期:2018-02-01 00:00:00

  • The Combined Use of a Neurocutaneous Flap and the Ilizarov Technique for Reconstruction of Large Soft Tissue Defects and Bone Loss in the Tibia.

    abstract:BACKGROUND:Management of posttraumatic large soft tissue defects and bone loss remains a therapeutic and surgical challenge for orthopedic surgeons. We assessed the use of a neurocutaneous flap and the Ilizarov technique in the reconstruction of severe composite defects in the tibia. METHODS:We retrospectively reviewe...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/SAP.0000000000000921

    authors: Xu J,Zhong WR,Cheng L,Wang CY,Wen G,Han P,Chai YM

    更新日期:2017-05-01 00:00:00

  • Fronto-orbito-sphenoidal fibrous dysplasia.

    abstract::Eight patients with fronto-orbito-sphenoidal fibrous dysplasia, aged between 9 and 37 years, half of them male, were radically or nearly radically excised with immediate autogenous bone graft reconstruction. They had had frontal bulging and proptosis on the affected sides for 3 to 20 years. Four had decreased vision o...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/00000637-198509000-00002

    authors: Chen YR,Fairholm D

    更新日期:1985-09-01 00:00:00

  • Biomechanical evaluation of cranial flap fixation techniques: comparative experimental study of suture, stainless steel wire, and rivetlike titanium clamp.

    abstract:OBJECTIVE:To study the techniques of cranial flap fixation (suture, stainless steel wire, and rivetlike titanium clamp) on biomechanics. METHODS:Twenty-four cadaver craniotomy flaps were reattached with either suture, stainless steel wire, or rivetlike titanium clamp. Cranial flap fixation was timed and measured for t...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/01.sap.0000239352.89088.26

    authors: Wang YR,Su ZP,Yang SX,Guo BY,Zeng YJ

    更新日期:2007-04-01 00:00:00

  • The First Hand Allotransplantation in Taiwan: A Report at 9 Months.

    abstract:PURPOSE:Hand transplantations have been initiated and have been encouraged by promising results for more than 1 decade. The aim of this study was to present the first case of hand transplantation performed in Taiwan. MATERIALS AND METHODS:On September 3, 2014, we transplanted the left distal forearm and hand of a brai...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/SAP.0000000000000758

    authors: Kuo YR,Chen CC,Chen YC,Yeh MC,Lin PY,Lee CH,Chang JK,Lin YC,Huang SC,Chiang YC,Chiu NM,Lee Y,Huang YC,Liang JL,Wu RW,Siu KK,Chung KC,Chiang MH,Pan CC,Wei FC

    更新日期:2016-02-01 00:00:00

  • Combined laser therapy for difficult dermal pigmentation: resurfacing and selective photothermolysis.

    abstract::Treating pigmented lesions of the skin, especially deep dermal pigmentations, are difficult to achieve satisfactory results without complications. To treat dermal pigmentations, such as nevus of Ota and congenital nevus, the combined therapy of a resurfacing laser (CO2) and a selective photothermolytic laser (the Q-Sw...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/00000637-200107000-00006

    authors: Park SH,Koo SH,Choi EO

    更新日期:2001-07-01 00:00:00

  • Treatment of obstructing inferior turbinates with intranasal corticosteroids.

    abstract::The most common cause of nasal obstruction is chronic enlargement of the inferior turbinate bones. The variety of medical and surgical treatments available for this condition bears testimony to their frequent ineffectiveness and the frustration of the physician or surgeon caring for these patients. Removal or destruct...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/00000637-197909000-00009

    authors: Baker DC

    更新日期:1979-09-01 00:00:00

  • Donor-site morbidity of the inferior gluteal musculocutaneous flap for breast reconstruction in teenagers.

    abstract::The purpose of this study is to objectively evaluate donor-site morbidity of the inferior gluteal musculocutaneous flap in teenagers. All cases of breast reconstruction performed between 1996 and 2005 using an inferior gluteal flap were reviewed. Flap size, weight, and pedicle origin were noted. Donor-site morbidity w...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/01.sap.0000259595.65804.2f

    authors: Dupéré S,Bergeron L,Bortoluzzi P,Del-Duca T,Caouette-Laberge L

    更新日期:2007-12-01 00:00:00

  • The prefabricated temporal island flap for eyelid and eye socket reconstruction in total orbital exenteration patients: A new method.

    abstract::Anophtalmic socket reconstruction is a challenging problem in plastic surgery. We had described a prefabricated superficial temporal fascia island flap and used this technique in >50 enucleation patients with severe socket contraction ending in excellent or good results for 28 years (Altindas- 1 procedure). However, t...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/SAP.0b013e3181c9dd17

    authors: Altindas M,Yucel A,Ozturk G,Sarac M,Kilic A

    更新日期:2010-08-01 00:00:00

  • Crane principle of the cross-leg fasciocutaneous flap: aesthetically pleasing technique for damaged dorsum of foot.

    abstract::Crushing injuries, including electrical burns on the dorsum of the foot, result in extensive tissue loss and exposure of bone and tendon. Debridement and covering of the wound with richly vascularized tissue are necessary at an early date. Flaps for the dorsum of the foot should be thin and the donor tissue to be sacr...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/00000637-198509000-00011

    authors: Uhm KI,Shin KS,Lew JD

    更新日期:1985-09-01 00:00:00

  • Giant keratoacanthomas.

    abstract::A patient with multiple keratoacanthomas association with a well-differentiated squamous cell carcinoma is presented. Incomplete excision of a keratoacanthoma deprives the pathologist of his main criteria in differentiating this lesion from a squamous cell carcinoma. Wide excision appears to be the treatment of choic...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/00000637-197908000-00015

    authors: Pickrell K,Villarreal-Rios A,Neale H

    更新日期:1979-08-01 00:00:00

  • Multifactorial refractory heterotopic ossification.

    abstract::Ectopic bone formation or "heterotopic ossification" can follow surgery, trauma, or neurologic injury, but the process is usually self-limited, localized to the site of injury, and responds to surgical treatment when necessary. Aggressive, systemic forms of heterotopic ossification exist that generate lesions that oft...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/01.sap.0000099624.04554.63

    authors: Gear AJ,Buckley C,Kaplan F,Vanbeek A

    更新日期:2004-03-01 00:00:00

  • Strategies for the Optimal Individualized Surgical Management of Craniofacial Fibrous Dysplasia.

    abstract:BACKGROUND:The surgical management of craniofacial fibrous dysplasia is controversial. The purpose of this study was to report the surgical outcomes of individualized management of craniofacial fibrous dysplasia of a single institution. METHODS:Data from patients (n = 20) with craniofacial fibrous dysplasia, who were ...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章

    doi:10.1097/SAP.0000000000000640

    authors: Denadai R,Raposo-Amaral CA,Marques FF,Ghizoni E,Buzzo CL,Raposo-Amaral CE

    更新日期:2016-08-01 00:00:00

  • Patient-reported outcomes and sexual function in vaginal reconstruction: a 17-year review, survey, and review of the literature.

    abstract::There are multiple techniques used to reconstruct the vagina after oncologic extirpation. However, the long-term functional results of vaginal reconstruction are not well appreciated.A review was conducted of all 27 consecutive patients undergoing vaginal reconstruction from 1990 to 2007. A modified Sexual Adjustment ...

    journal_title:Annals of plastic surgery

    pub_type: 杂志文章,评审

    doi:10.1097/SAP.0b013e3181af8fca

    authors: Scott JR,Liu D,Mathes DW

    更新日期:2010-03-01 00:00:00