Obstructive sleep apnea in children with syndromic craniosynostosis: long-term respiratory outcome of midface advancement.

Abstract:

:Almost 50% of patients with Apert, Crouzon or Pfeiffer syndrome develop obstructive sleep apnea (OSA), mainly due to midface hypoplasia. Midface advancement is often the treatment of choice, but the few papers on long-term outcome report mixed results. This paper aimed to assess the long-term respiratory outcome of midface advancement in syndromic craniosynostosis with OSA and to determine factors contributing to its efficacy. A retrospective study was performed on 11 patients with moderate or severe OSA, requiring oxygen, continuous positive airway pressure (CPAP), or tracheostomy. Clinical symptoms, results of polysomnography, endoscopy and digital volume measurement of the upper airways on CT scan before and after midface advancement were reviewed. Midface advancement had a good respiratory outcome in the short term in 6 patients and was ineffective in 5. In all patients without respiratory effect or with relapse, endoscopy showed obstruction of the rhino- or hypopharynx. The volume measurements supported the clinical and endoscopic outcome. Despite midface advancement, long-term dependence on, or indication for, CPAP or tracheostomy was maintained in 5 of 11 patients. Pharyngeal collapse appeared to play a role in OSA. Endoscopy before midface advancement is recommended to identify airway obstruction that may interfere with respiratory improvement after midface advancement.

authors

Bannink N,Nout E,Wolvius EB,Hoeve HL,Joosten KF,Mathijssen IM

doi

10.1016/j.ijom.2009.11.021

subject

Has Abstract

pub_date

2010-02-01 00:00:00

pages

115-21

issue

2

eissn

0901-5027

issn

1399-0020

pii

S0901-5027(09)01187-4

journal_volume

39

pub_type

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