Abstract:
:A hospital-based case-control study was conducted to identify interactions between the 538(T-->C) polymorphic site of bone morphogenetic protein 4 gene (BMP4T538C) and exposures in pregnancy with nonsyndromic cleft lip, with or without cleft palate (nsCL/P). Associations between offspring polymorphism of BMP4T538C, paternal smoking, paternal high-risk drinking, maternal passive smoking, and maternal multivitamin supplement with nsCL/P were analyzed by logistic regression analysis. BMP4T538C polymorphism, maternal passive smoking exposures and maternal multivitamin use were associated with the risk of nsCL/P but paternal smoking and paternal high-risk drinking were not. Gene-environment interactions were analyzed using the multifactor dimensionality reduction (MDR) method. The two-factor model including maternal passive smoking and BMP4T538C, was the best for predicting nsCL/P risk with a maximum cross-validation consistency (10/10) and a maximum average testing accuracy(0.605; P<0.0001). The findings suggested that: BMP4T538C could be used as a genetic susceptibility marker for nsCL/P; maternal passive smoking exposure is a risk factor for nsCL/P; maternal multivitamin supplements are a protective factor; the synergistic effect of BMP4T538C and maternal passive smoking could provide a new tool for identifying individuals at high risk of nsCL/P, and provides additional evidence that nsCL/P is determined by genetic and environmental factors.
journal_name
Int J Oral Maxillofac Surgjournal_title
International journal of oral and maxillofacial surgeryauthors
Jianyan L,Zeqiang G,Yongjuan C,Kaihong D,Bing D,Rongsheng Ldoi
10.1016/j.ijom.2009.10.010subject
Has Abstractpub_date
2010-01-01 00:00:00pages
50-6issue
1eissn
0901-5027issn
1399-0020pii
S0901-5027(09)01132-1journal_volume
39pub_type
杂志文章abstract::Open reduction of dislocated subcondylar fractures was carried out in 19 adult patients between 1990 and 1992. A comparison of the results between two groups of patients was made 1 year after trauma. The reference group consisted of patients with the same type of fracture but treated with only intermaxillary fixation ...
journal_title:International journal of oral and maxillofacial surgery
pub_type: 杂志文章
doi:10.1016/s0901-5027(96)80052-x
更新日期:1996-04-01 00:00:00
abstract::This literature review assessed the risk factors linked to inferior dental nerve (IDN) and lingual nerve (LN) deficits following lower wisdom tooth surgery. A computer search of several databases with specified key words was performed. 32 articles were selected; the risk factors for IDN deficit were reported in 4 arti...
journal_title:International journal of oral and maxillofacial surgery
pub_type: 杂志文章,评审
doi:10.1016/j.ijom.2010.09.005
更新日期:2011-01-01 00:00:00
abstract::A double-blind randomised cross-over study to compare 2 regimes of paracetamol and diflunisal for postoperative pain relief following 3rd molar surgery was designed. 35 patients received one of the regimes at one visit and the alternative at the other visit. Both drugs, namely a single dose of 500 mg of diflunisal giv...
journal_title:International journal of oral and maxillofacial surgery
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0901-5027(89)80107-9
更新日期:1989-06-01 00:00:00
abstract::Salivary gland tumours are uncommon with a broad heterogeneity. The most common benign tumour is the pleomorphic adenoma, whereas mucoepidermoid carcinoma and adenoid cystic carcinoma predominate among the malignancies. Most salivary gland tumours occur in the parotid, and consequently clinical and biological data are...
journal_title:International journal of oral and maxillofacial surgery
pub_type: 杂志文章
doi:10.1016/j.ijom.2004.01.010
更新日期:2004-09-01 00:00:00
abstract::A postal survey of the views of 100 international experts in temporomandibular joint surgery was performed. Generally, there was a considerable degree of consensus on definitions, diagnosis, and broad treatment principles. However, specific surgical techniques for particular stages of internal derangement and osteoart...
journal_title:International journal of oral and maxillofacial surgery
pub_type: 杂志文章
doi:10.1016/s0901-5027(05)80804-5
更新日期:1993-04-01 00:00:00
abstract::Although the risk factors and diagnosis of heterotopic ossification (HO) are discussed in the orthopedics literature, the etiology of HO, as well as its prevention and management, remain theoretical. Furthermore, there is a lack of information in the literature regarding HO in temporomandibular joint replacement (TMJR...
journal_title:International journal of oral and maxillofacial surgery
pub_type: 杂志文章,评审
doi:10.1016/j.ijom.2017.06.016
更新日期:2017-12-01 00:00:00
abstract::The aim of this study was to determine the material composition and cell-mediated remodelling of different calcium phosphate-based bone substitutes. Osteoclasts were cultivated on bone substitutes (Cerabone, Maxresorb, and NanoBone) for up to 5 days. Bafilomycin A1 addition served as the control. To determine cellular...
journal_title:International journal of oral and maxillofacial surgery
pub_type: 杂志文章
doi:10.1016/j.ijom.2013.10.017
更新日期:2014-04-01 00:00:00
abstract::Dislocation of the mandibular condyle into the middle cranial fossa is extremely rare. The authors present a case of superior dislocation of left condyle into the middle cranial fossa. The dislocated condyle was reduced successfully and then a flap of temporal muscle and a thin titanium network were used to repair the...
journal_title:International journal of oral and maxillofacial surgery
pub_type: 杂志文章
doi:10.1016/j.ijom.2010.02.028
更新日期:2011-01-01 00:00:00
abstract::There is controversy in the literature regarding donor site morbidity following radial forearm flap harvesting. The aim of this study was to verify possible functional and aesthetic impairments at the donor site. Thirty-five patients who underwent maxillofacial reconstruction using radial forearm flap were asked to gi...
journal_title:International journal of oral and maxillofacial surgery
pub_type: 杂志文章
doi:10.1054/ijom.2000.0005
更新日期:2001-02-01 00:00:00
abstract::The optimal management of mandibular angle fractures remains controversial. The aim of this experimental study was to test the stability and resistance to mechanical force of a new titanium miniplate design. Thirty fresh sheep hemimandibles, sectioned at the angle region, were used to evaluate two plating techniques. ...
journal_title:International journal of oral and maxillofacial surgery
pub_type: 杂志文章
doi:10.1016/j.ijom.2014.01.011
更新日期:2014-07-01 00:00:00
abstract::A clinically successful technique for temporomandibular joint (TMJ) arthroscopy by the inferolateral approach is reported. The outline of the superior and inferior articular cavities of the TMJ except for the lower anterior pouch could be visualised; arthroscopy could be performed on most patients under local anesthes...
journal_title:International journal of oral and maxillofacial surgery
pub_type: 杂志文章
doi:10.1016/s0300-9785(86)80029-1
更新日期:1986-08-01 00:00:00
abstract::Maxillofacial fractures are often associated with blunt head injuries, of which skull base trauma is a common component. However, most oral and maxillofacial surgeons do not provide definitive management of temporal bone fractures involving the skull base and their sequelae. Persistent cerebrospinal fluid (CSF) leakag...
journal_title:International journal of oral and maxillofacial surgery
pub_type: 杂志文章
doi:10.1016/j.ijom.2014.03.002
更新日期:2014-08-01 00:00:00
abstract::A case is described of a patient with progressive HA who presented because of left TMJ pain, jaw locking and ipsilateral masticatory muscle spasm. Several reports exist in the literature of masticatory muscle spasm associated with HA. A diagnosis of TMJPDS was made and an occlusal splint was provided which produced re...
journal_title:International journal of oral and maxillofacial surgery
pub_type: 杂志文章
doi:10.1016/s0901-5027(88)80044-4
更新日期:1988-08-01 00:00:00
abstract::The aim of this study was to analyse signs and symptoms present in patients with parotid gland carcinoma and to assess their prognostic value. A retrospective study of data from 131 patients who were treated surgically was performed. Evaluation of prognostic factors was possible in 109 patients who completed a minimum...
journal_title:International journal of oral and maxillofacial surgery
pub_type: 杂志文章
doi:10.1016/j.ijom.2011.12.020
更新日期:2012-07-01 00:00:00
abstract::The question has arisen as to whether mandibular setback may possibly cause sleep-related breathing disorders (SRBD). To evaluate the possible effects of mandibular setback on posterior airway space (PAS), 16 consecutive patients were examined prospectively. All patients underwent surgical mandibular setback using bil...
journal_title:International journal of oral and maxillofacial surgery
pub_type: 杂志文章
doi:10.1016/s0901-5027(06)80024-x
更新日期:1996-10-01 00:00:00
abstract::This study assessed the relationship between craniofacial characteristics and the size of the pharyngeal airway space (PAS), taking into account head posture. Sixty dental students 25-30 years of age (30 men and 30 women) were examined by lateral cephalometry. The data were corrected with the use of appropriate regres...
journal_title:International journal of oral and maxillofacial surgery
pub_type: 杂志文章
doi:10.1016/j.ijom.2005.04.022
更新日期:2006-02-01 00:00:00
abstract::This technical note demonstrates the benefits of preoperative planning, involving the use of rapid prototype models and rehearsal of the surgical procedure, using image-guided navigational surgery. Optimum reconstruction of large defects can be achieved with this technique. ...
journal_title:International journal of oral and maxillofacial surgery
pub_type: 杂志文章
doi:10.1016/j.ijom.2013.04.019
更新日期:2013-08-01 00:00:00
abstract::The Na+/H+ exchanger 1 (NHE1) plays a significant role in acidifying the tumour microenvironment, potentially contributing to the tumour's malignant potential. The mechanism by which NHE1 mediates cell invasion and migration, especially in human tongue squamous cell carcinoma (hTSCC), is unknown. In this study, the au...
journal_title:International journal of oral and maxillofacial surgery
pub_type: 杂志文章
doi:10.1016/j.ijom.2012.03.001
更新日期:2012-10-01 00:00:00
abstract::Malignant mesothelioma is a rare tumor arising from the pleura or peritoneum. Distant hematogenous metastasis is seen in more than half of cases, preferentially to the brain, lung, bone and soft tissues [Br. J. Dis. Chest 70 (1976) 246]. There has been only one previous report of this tumor metastasizing to the jaw bo...
journal_title:International journal of oral and maxillofacial surgery
pub_type: 杂志文章
doi:10.1016/j.ijom.2003.10.017
更新日期:2004-12-01 00:00:00
abstract::Temporomandibular joint (TMJ) dislocation can be classified into four groups (anterior, posterior, lateral, and superior) depending on the direction of displacement and the location of the condylar head. All the groups are rare except for anterior dislocation. 'Inverse' TMJ dislocation is a bilateral anterior and supe...
journal_title:International journal of oral and maxillofacial surgery
pub_type: 杂志文章
doi:10.1016/j.ijom.2011.02.012
更新日期:2011-08-01 00:00:00
abstract::The aim of this study was to analyze the contents of referral letters related to clinical history and reason for consultation. A total of 236 consecutive referral letters were evaluated. Analysis of the referral letters was based on key items concerning patient identification, chief complaint, previous consultation, l...
journal_title:International journal of oral and maxillofacial surgery
pub_type: 杂志文章
doi:10.1054/ijom.2001.0108
更新日期:2001-10-01 00:00:00
abstract::We describe a new temporomandibular joint (TMJ) arthrocentesis technique using the irrigation pump from a surgical and dental implant motor, providing the highest hydraulic pressure reported in the literature for TMJ lavage. ...
journal_title:International journal of oral and maxillofacial surgery
pub_type: 杂志文章
doi:10.1016/j.ijom.2008.11.005
更新日期:2009-01-01 00:00:00
abstract::This study aimed to determine the effect of the co-administration of dexamethasone 8mg and nimesulide 100mg given 1h before mandibular third molar surgery. A prospective, randomized, triple-blind, split-mouth clinical trial was developed at the study institution in Pernambuco, Brazil. A pilot study was first performed...
journal_title:International journal of oral and maxillofacial surgery
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ijom.2016.10.011
更新日期:2017-02-01 00:00:00
abstract::A randomized clinical trial was performed to evaluate differences in postoperative neurosensory disturbance (NSD) between two methods of mandibular advancement surgery. A total of 66 non-syndromal class II patients with mandibular hypoplasia were randomized for either distraction osteogenesis (DO) or bilateral sagitta...
journal_title:International journal of oral and maxillofacial surgery
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ijom.2014.10.010
更新日期:2015-02-01 00:00:00
abstract::Numerous reports exist upon clinical viewpoints of the four cervical cutaneous nerves. Unfortunately, a detailed description of the cervical cutaneous nerves has not yet been published. For this reason, administering effective anaesthesia to a particular nerve branch is difficult. The aim of this study was to clarify ...
journal_title:International journal of oral and maxillofacial surgery
pub_type: 杂志文章
doi:10.1054/ijom.2001.0165
更新日期:2002-02-01 00:00:00
abstract::Computer-aided surgical navigation technology is commonly used in craniomaxillofacial surgery. It offers substantial improvement regarding esthetic and functional aspects in a range of surgical procedures. Based on augmented reality principles, where the real operative site is merged with computer generated graphic in...
journal_title:International journal of oral and maxillofacial surgery
pub_type: 杂志文章,评审
doi:10.1016/j.ijom.2004.03.018
更新日期:2005-01-01 00:00:00
abstract::The treatment method for early stage tongue cancer is still controversial in Japan. The aim of this study is to compare the prognosis for patients with early tongue cancer treated with brachytherapy and surgery. A retrospective study was conducted to compare the efficacy of low-dose-rate brachytherapy (LDR), high-dose...
journal_title:International journal of oral and maxillofacial surgery
pub_type: 杂志文章
doi:10.1016/j.ijom.2005.02.015
更新日期:2005-10-01 00:00:00
abstract::The purpose of this study was to assess whether genetic variation is a predictor for the development of medication-related osteonecrosis of the jaws (MRONJ) in patients receiving bisphosphonate therapy for various conditions. A systematic review based on the PRISMA guidelines was performed. A search strategy was devel...
journal_title:International journal of oral and maxillofacial surgery
pub_type: 杂志文章
doi:10.1016/j.ijom.2019.04.014
更新日期:2019-10-01 00:00:00
abstract::The solitary fibrous tumour (SFT), also known as a localized fibrous mesothelioma, is a neoplasm characterized by the proliferation of capillaries surrounded by masses of round or spindle-shaped cells. SFT has been discovered in many locations, however, it is extremely rare for SFT to be found in the intraoral region....
journal_title:International journal of oral and maxillofacial surgery
pub_type: 杂志文章
doi:10.1054/ijom.2001.0201
更新日期:2002-12-01 00:00:00
abstract::Many clinical guidelines for investigating lymphomas advise that surgical excision biopsy (SEB) should be performed for a confident diagnosis. It is increasingly recognized in clinical practice that ultrasound-guided core needle biopsy (USCNB) is a reliable diagnostic technique. We aimed to investigate the diagnostic ...
journal_title:International journal of oral and maxillofacial surgery
pub_type: 杂志文章
doi:10.1016/j.ijom.2020.07.005
更新日期:2020-07-29 00:00:00