Pantoprazole: a proton pump inhibitor.

abstract：:Sublingual buprenorphine [Subutex(R)] is used to treat opioid dependence. However, illicit intravenous (IV) injection of buprenorphine is a widespread problem. This survey investigated the IV misuse of buprenorphine among patients receiving drug replacement therapy at the Drug Addiction Centre in Udine, Italy. All pat...

journal_title：Clinical drug investigation

authors： Moratti E,Kashanpour H,Lombardelli T,Maisto M

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Warfarin is a commonly used oral anticoagulant and its interaction with other drugs can result in serious thrombotic or bleeding events. Currently, there is no definitive evidence on the possibility of an interaction between warfarin and oseltamivir. OBJECTIVE:The objective of this study was to investigate ...

journal_title：Clinical drug investigation

authors： Lee SH,Kang HR,Jung JW,Kwon JW,Hong KS,Yu KS,Cho SH

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:Epidemiological studies and clinical trials have shown that prevention of cardiovascular disease, the ultimate goal of hypertension treatment, requires a sufficient reduction in blood pressure. OBJECTIVE:The primary objective of this study was to compare the mean decrease in systolic (SBP) and diastolic (DB...

journal_title：Clinical drug investigation

authors： Pareek A,Chandurkar NB,Sharma R,Tiwari D,Gupta BS

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Olanzapine is an atypical antipsychotic indicated for the treatment of schizophrenia and, either as monotherapy or as an adjunct to lithium or valproate, for bipolar I disorder. Multiple daily doses of olanzapine do not affect the pharmacokinetics of lithium or valproate; therefore, concomitant...

journal_title：Clinical drug investigation

authors： Sun L,Yagoda S,Yao B,Graham C,von Moltke L

更新日期：2020-01-01 00:00:00

abstract：:Page 806, column 1, line 3: The text, which previously read. ...

journal_title：Clinical drug investigation

authors： Lyseng-Williamson KA

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVE:Weight gain during insulin therapy can be a challenging problem in already overweight type 2 diabetes mellitus patients, affecting treatment compliance and long-term prognosis. The analogue insulin detemir has been reported to have a weight-sparing effect compared with other basal insulins. This pooled analys...

journal_title：Clinical drug investigation

authors： Raslová K,Tamer SC,Clauson P,Karl D

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Recent clinical studies have documented the analgesic, anti-inflammatory, antioxidative and anxiolytic effects of exogenous melatonin. The pharmacokinetic properties of melatonin have primarily been investigated in experimental studies. OBJECTIVE:The aim of this study was to estimate the pharmacokinetics of...

journal_title：Clinical drug investigation

authors： Harpsøe NG,Andersen LP,Mielke LV,Jønsson B,Jenstrup MT,Gögenur I,Rosenberg J

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The optimal choice for first- and second-line antiseizure medications for pediatric patients with convulsive status epilepticus remains ambiguous. The present study aimed to estimate the comparative effect on the efficacy and safety of different antiseizure medications in pediatric patients wit...

journal_title：Clinical drug investigation

authors： Zhang Y,Liu Y,Liao Q,Liu Z

更新日期：2021-01-01 00:00:00

abstract：:A pharmacokinetic study was carried out in patients with unresectable colorectal liver metastases who had primarily been included in a phase II trial of intra-arterial cisplatin (DDP) plus intravenous fluorouracil. Ten patients of those accrued for the clinical study underwent the pharmacokinetic investigation upon li...

journal_title：Clinical drug investigation

authors： Civalleri D,Esposito M,De Cain F,Balletto N,Mondini G,Gogioso L,Viale M,Vannozzi MO

更新日期：1996-08-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Little is known about the effects of the calcium channel antagonist manidipine when it is added as a third drug in non-controlled hypertensive patients with diabetes mellitus receiving dual antihypertensive therapy. The aim of this study was to evaluate the response in terms of blood pressure (...

journal_title：Clinical drug investigation

authors： Martell-Claros N,de la Cruz JJ

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVE:This open, prospective, non-interventional, non-randomised, multi-centre postmarketing surveillance study was conducted over a mean period of 13.9 weeks to assess the efficacy, safety and acceptance of acarbose in Chinese patients with type 2 diabetes mellitus and subjects with impaired glucose tolerance (IGT...

journal_title：Clinical drug investigation

authors： Pan CY,Landen H

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Several systematic reviews and meta-analyses have been conducted including an analysis to investigate the difference between ethnic groups in the glucose-lowering efficacy of dipeptidyl peptidase-4 (DPP-4) inhibitors. This study assessed the factors related to the glucose-lowering efficacy and ...

journal_title：Clinical drug investigation

authors： Fujita K,Kaneko M,Narukawa M

更新日期：2017-03-01 00:00:00

abstract：:Androgenetic alopecia (AGA) is characterized by non-scarring follicle miniaturization. Despite the success of approved therapies, commonly reported side effects and the need for continual use has led to the investigation of alternative therapies. The aim of this paper is to critically review the success of off-label, ...

journal_title：Clinical drug investigation

authors： Gupta AK,Mays RR,Versteeg SG,Shear NH,Piguet V,Piraccini BM

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:Muscle wasting is common and insidious in end-stage renal disease (ESRD). Loss of muscle quantity and quality reduces quality of life and increases mortality in ESRD patients. Additionally, secondary hyperparathyroidism (SHPT) causes muscle atrophy. Meanwhile, vitamin D, which is used for SHPT treatment, pla...

journal_title：Clinical drug investigation

authors： Mori A,Nishino T,Obata Y,Nakazawa M,Hirose M,Yamashita H,Uramatsu T,Shinzato K,Kohno S

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The new oral anticoagulants (NOACs) are used for the prevention of thromboembolic complications in patients with non-valvular atrial fibrillation (AF) and those at risk of deep venous thrombosis. Their rapid onset of action and predictable pharmacokinetic and pharmacodynamic profiles make them...

journal_title：Clinical drug investigation

authors： Acanfora D,Acanfora C,Scicchitano P,Longobardi M,Furgi G,Casucci G,Lanzillo B,Dentamaro I,Zito A,Incalzi RA,Ciccone MM

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Status epilepticus (SE) is an important emergency situation associated with high morbidity and mortality. The goal of pharmacological therapy-rapid seizure termination-is only achieved in just over half of patients with first-line anti-epileptic drug (AED) therapy and many patients require sec...

journal_title：Clinical drug investigation

authors： Moreno Morales EY,Fernandez Peleteiro M,Bondy Peña EC,Domínguez Lorenzo JM,Pardellas Santiago E,Fernández A

更新日期：2015-07-01 00:00:00

abstract：:HMG-CoA reductase inhibitors (statins) are highly effective drugs for prevention of cardiovascular events in high-risk patients. Due to the widespread prescription of these agents, special attention should be given to their rare adverse effects when these may have severe outcomes. Here, we report two cases of localize...

journal_title：Clinical drug investigation

authors： Fadini GP,Manzato E,Crepaldi C,de Kreutzenberg S,Tiengo A,Avogaro A

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Patients with cancer are at high risk of major depressive disorder (MDD), but little is known about their MDD treatment. We investigated the use of antidepressants and other drugs for MDD after cancer diagnosis, and patient characteristics associated with their use. METHODS:Adults with a new c...

journal_title：Clinical drug investigation

authors： Akechi T,Fujimoto S,Mishiro I,Murase K

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Golimumab is a fully human anti-tumor necrosis factor monoclonal antibody approved for the treatment of rheumatoid arthritis (RA), psoriatic arthritis (PsA), and ankylosing spondylitis (AS). This study estimated rates of prespecified outcomes in patients with RA, PsA or AS initiating golimumab ...

journal_title：Clinical drug investigation

authors： Ziyadeh NJ,Geldhof A,Noël W,Otero-Lobato M,Esslinger S,Chakravarty SD,Wang Y,Seeger JD

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND AND AIM:Gastro-oesophageal reflux disease is a common medical problem that places a significant financial burden on outpatient pharmaceutical expenditure. A substantial proportion of this expenditure can be attributed to the use of proton pump inhibitors (PPIs). The aim of this analysis was to evaluate the c...

journal_title：Clinical drug investigation

authors： Lucioni C,Mazzi S,Rossi C

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:The use of budesonide/formoterol as both maintenance and reliever therapy in asthma is recommended in many countries; however, there are limited data available for the Asian patient population. OBJECTIVE:This study aimed to evaluate the short-term safety and tolerability of a fixed high-dose combination of ...

journal_title：Clinical drug investigation

authors： Saito T,Hasunuma T

更新日期：2012-01-01 00:00:00

abstract：:Despite the availability of effective pain treatments, there are numerous barriers to effective management resulting in a large proportion of patients not achieving optimal pain control. Chronic pain is inadequately treated because of a combination of cultural, societal, educational, political and religious constraint...

journal_title：Clinical drug investigation

authors： Zuccaro SM,Vellucci R,Sarzi-Puttini P,Cherubino P,Labianca R,Fornasari D

更新日期：2012-02-22 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Ramucirumab is a fully immunoglobulin G (lgG) monoclonal antibody targeting vascular endothelial growth factor receptor type 2 (VEGFR2). Previous clinical trials suggested ramucirumab could improve the survival and increase the risk of adverse effects. Here, we aimed to assess the efficacy and...

journal_title：Clinical drug investigation

authors： Wang K,Qu X,Wang Y,Dong W,Shen H,Zhang T,Ni Y,Liu Q,Du J

更新日期：2016-01-01 00:00:00

abstract：:In an in vivo rat model of myocardial infarction, opioid receptor stimulation has been observed to result in a reduction in infarct size similar to that produced by ischaemic preconditioning. The ability of glibenclamide to abolish this effect suggests an involvement of the myocardial ATP-sensitive potassium (K(ATP)) ...

journal_title：Clinical drug investigation

authors： McCormack KJ,Chapleo CB

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:Elderly patients are more susceptible to Clostridium difficile infections (CDIs). Despite existing guidelines, there is no specific treatment for CDI in geriatrics. Vancomycin is commonly used in the treatment of CDI. Teicoplanin is an alternative glycopeptide which recently received marketing authorization ...

journal_title：Clinical drug investigation

authors： Davido B,Leplay C,Bouchand F,Dinh A,Villart M,Le Quintrec JL,Teillet L,Salomon J,Michelon H

更新日期：2017-07-01 00:00:00

abstract：:Early initiation of rational and effective combination therapy consisting of antihypertensive drugs with two different and complementary mechanisms of actions is increasingly becoming accepted in clinical practice and by guidelines as a first-line approach to control blood pressure (BP) and prevent cardiovascular outc...

journal_title：Clinical drug investigation

authors： da Silva PM

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVE:To estimate the cost effectiveness of venlafaxine compared with generic fluoxetine and generic amitriptyline used in major depressive disorder in primary care in the UK. METHODS:A decision-tree model for the treatment of major depressive disorder was constructed using a Delphi panel. The tree was populated w...

journal_title：Clinical drug investigation

authors： Lenox-Smith A,Greenstreet L,Burslem K,Knight C

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Schizophrenia is a severe public health problem and one of the top ten causes of disability, affecting about 1.1% of the world's population. Paliperidone is a new atypical antipsychotic used to treat schizophrenia. Several case reports about unexpected adverse drug reactions of paliperidone ha...

journal_title：Clinical drug investigation

authors： Seo DE,Kim S,Park BJ

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVE:The efficacy and tolerability of acarbose were examined in a postmarketing surveillance study of 27 803 patients with diabetes mellitus (26 044 were diagnosed as having type 2 diabetes) over a 12-week treatment period. PATIENTS AND M ethods: Overall efficacy data were reported for type 1 and type 2 diabetes, ...

journal_title：Clinical drug investigation

authors： Spengler M,Schmitz H,Landen H

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The time-course when changes in glycemic control and body weight were first manifest in patients with type 2 diabetes mellitus (T2DM) treated with a combination of insulin degludec and liraglutide (IDegLira) was assessed, comparing IDegLira to its individual components. METHODS:Data from week...

journal_title：Clinical drug investigation

authors： Vilsbøll T,Vora J,Jarlov H,Kvist K,Blonde L

更新日期：2016-04-01 00:00:00