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Immunomagnetic depletion of CD6+ cells from bone marrow and peripheral blood.

Abstract：

:Depletion of donor CD6+ cells in HLA-identical allogeneic bone marrow transplantation has been reported to reduce graft-versus-host disease without interfering with engraftment. We have established an immunomagnetic cell separation technique capable of producing a 2-3 log depletion of CD6+ cells. Median recovery of CD6- cells and hematopoietic progenitor cells was 65-70%, and cell viability was unaffected. Significant numbers of CD2+, CD3+ cells responsive to phytohemagglutinin (PHA), OKT3, recombinant interleukin-2 (rIL-2), and allogeneic cells remained after depletion, and the number of cells able to respond to stimulation with PHA and IL-2 in vitro was reduced by only 1-2 log. These observations are not easily reconciled with the ability of CD6 depletion to prevent GVHD, but raise the question whether the depletion causes a sufficient reduction of the T cell load or removes a critical T cell subset.

journal_name

Bone Marrow Transplant

journal_title

Bone marrow transplantation

authors

Egeland T,Albrechtsen D,Martin PJ,Hansen JA

subject

Has Abstract

pub_date

1990-03-01 00:00:00

pages

193-8

issue

3

eissn

0268-3369

issn

1476-5365

journal_volume

5

pub_type

杂志文章

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