Headache, circumoral paresthesia, and facial flushing associated with high-dose carmustine infusion.

Abstract:

:We describe seven patients who developed symptoms including severe headache, circumoral paresthesia, and facial flushing during high-dose carmustine (BCNU) infusion as part of the preparative regimen for autologous peripheral blood stem cell (PBSC) transplantation for metastatic breast cancer. Five patients responded to pain medications, including partial and complete opiate receptor agonists. Premedication of subsequent doses of BCNU with corticosteroids, pain medications, or benzodiazepines lessened, but did not prevent the same symptoms from recurring. The incidence and mechanism of this toxicity are unknown, but this adverse syndrome should be considered when administering high-dose BCNU infusions.

journal_name

Bone Marrow Transplant

authors

Woo MH,Ippoliti C,Bruton J,Mehra R,Champlin R,Przepiorka D

doi

10.1038/sj.bmt.1700743

subject

Has Abstract

pub_date

1997-04-01 00:00:00

pages

845-7

issue

8

eissn

0268-3369

issn

1476-5365

journal_volume

19

pub_type

杂志文章
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    更新日期:1997-07-01 00:00:00

  • Tacrolimus and mycofenolate mofetil as GvHD prophylaxis following nonmyeloablative conditioning and unrelated hematopoietic SCT for adult patients with advanced hematologic diseases.

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    authors: Zohren F,Schroeder T,Czibere A,Fenk R,Bruns I,Kondakci M,Saure C,Haas R,Kobbe G

    更新日期:2011-05-01 00:00:00

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    authors: Shimoji S,Kato K,Eriguchi Y,Takenaka K,Iwasaki H,Miyamoto T,Oda Y,Akashi K,Teshima T

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  • Hematopoietic stem cell transplantation activity in Europe 1999.

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    journal_title:Bone marrow transplantation

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    doi:

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    更新日期:1993-01-01 00:00:00

  • Safety and efficacy assessment of plerixafor in patients with multiple myeloma proven or predicted to be poor mobilizers, including assessment of tumor cell mobilization.

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    pub_type: 杂志文章

    doi:10.1038/bmt.2009.130

    authors: Tricot G,Cottler-Fox MH,Calandra G

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  • Rituximab-based allogeneic transplant for chronic lymphocytic leukemia with comparison to historical experience.

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    journal_title:Bone marrow transplantation

    pub_type: 杂志文章

    doi:10.1038/s41409-019-0660-8

    authors: Shadman M,Maloney DG,Storer B,Sandmaier BM,Chauncey TR,Smedegaard Andersen N,Niederwieser D,Shizuru J,Bruno B,Pulsipher MA,Maziarz RT,Agura ED,Hari P,Langston AA,Maris MB,McSweeney PA,Storb R,Sorror ML

    更新日期:2020-01-01 00:00:00

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    journal_title:Bone marrow transplantation

    pub_type: 杂志文章,评审

    doi:10.1038/bmt.2014.251

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    更新日期:2015-02-01 00:00:00

  • Tacrolimus and minidose methotrexate for prevention of acute graft-versus-host disease after HLA-mismatched marrow or blood stem cell transplantation.

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    pub_type: 杂志文章

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    authors: Przepiorka D,Khouri I,Ippoliti C,Ueno NT,Mehra R,Körbling M,Giralt S,Gajewski J,Fischer H,Donato M,Cleary K,Claxton D,Chan KW,Braunschweig I,van Besien K,Andersson BS,Anderlini P,Champlin R

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    pub_type: 杂志文章

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    authors: Teachey DT,Russo P,Orenstein JM,Didier ES,Bowers C,Bunin N

    更新日期:2004-02-01 00:00:00

  • Single and double autotransplants for relapsing/refractory Hodgkin's disease: results of two consecutive trials.

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    更新日期:1997-03-01 00:00:00

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    更新日期:2020-11-01 00:00:00

  • Methotrexate resistance conferred by transplantation of drug-resistant transgenic marrow cells fractionated bycounterflow elutriation.

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    pub_type: 杂志文章

    doi:10.1038/sj.bmt.1701984

    authors: James R,May C,Diers M,Wagner J,McIvor R

    更新日期:1999-10-01 00:00:00

  • Consensus opinion on immune-mediated cytopenias after hematopoietic cell transplant for inherited metabolic disorders.

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  • Stem cell transplant for Waldenström macroglobulinemia: an underutilized technique.

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    doi:

    authors: Hochhaus A,Lin F,Reiter A,Skladny H,Hehlmann R,Goldman JM,Cross NC

    更新日期:1996-05-01 00:00:00

  • Allogeneic haematopoietic stem cell transplantation in children with acute lymphoblastic leukaemia: the BFM/IBFM/EBMT concepts.

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    更新日期:2005-03-01 00:00:00

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    更新日期:2005-06-01 00:00:00

  • Impact of sex incompatibility on the outcome of single-unit cord blood transplantation for adult patients with hematological malignancies.

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    authors: Doney K,Loken M,Bryant E,Smith A,Appelbaum F

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    doi:10.1038/bmt.2016.101

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    更新日期:2016-09-01 00:00:00

  • Unusual recurrence of chronic myelogenous leukemia following bone marrow transplantation.

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    doi:

    authors: Millot F,Facon T,Kerckaert JP,Fenaux P,Lai JL,Parent M,Bauters F,Jouet JP

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  • High-dose chemotherapy with autologous stem cell rescue in women with metastatic breast cancer with involved bone marrow: a role for peripheral blood progenitor transplant.

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    journal_title:Bone marrow transplantation

    pub_type: 杂志文章

    doi:

    authors: Myers SE,Mick R,Williams SF

    更新日期:1994-04-01 00:00:00

  • Treatment of refractory lymphoma with high dose cytarabine, cyclophosphamide and either TBI or VP-16 followed by autologous bone marrow transplantation.

    abstract::This study was designed to test the efficacy and toxicity of combining high-dose cytarabine (3 g/m2 every 12 h x 8 doses day -7 to day -4, total dose 24 g/m2), methyl prednisolone (0.5 mg/kg every 4 h day -7 to day -1), and cyclophosphamide (CY) (60 mg/kg day -3 and day -2) with either total body irradiation (TBI) (90...

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    doi:

    authors: Broun ER,Tricot G,Akard L,Nichols C,Cheerva A,Jansen J

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  • Significant reduction of cytomegalovirus (CMV) disease by prophylaxis with CMV hyperimmune globulin plus oral acyclovir.

    abstract::The effect of prophylactic intravenous administration of a cytomegalovirus (CMV) hyperimmune globulin with a high titer of neutralizing antibodies plus oral acyclovir was studied in 93 consecutive bone marrow transplant recipients. In spite of receiving blood products unscreened for CMV only six patients developed CMV...

    journal_title:Bone marrow transplantation

    pub_type: 杂志文章

    doi:

    authors: Einsele H,Vallbracht A,Friese M,Schmidt H,Haen M,Dopfer R,Niethammer D,Waller HD,Ehninger G

    更新日期:1988-11-01 00:00:00