Viridans streptococcal septicaemia in neutropenic patients: role of proinflammatory cytokines.

Abstract:

:The immunostimulatory activity of viridans streptococcal strains isolated from neutropenic patients with severe sepsis (n=9) or uncomplicated bacteraemia (n=10) was compared. Peripheral blood mononuclear cells from healthy individuals were stimulated with heat-killed bacteria or culture supernatants, and cytokine production assessed. All strains were potent inducers of IL1beta, IL8, and TNFalpha production. Heat-killed bacteria induced consistently higher IL1beta and TNFalpha production than did the cell-free bacterial supernatants (P<0.01). The strains did not induce any proliferative response, nor any significant TNFbeta or IFNgamma production. No difference in cytokine-inducing capacity could be detected between the cohorts of severe and nonsevere isolates. Comparison of strains causing severe and nonsevere episodes in the same patient (n=2) revealed a significantly higher induction of IL1beta by the severe episodes associated isolates as compared to the nonsevere (P<0.04). The study underscores the importance of the host-pathogen interplay in determining the level of inflammation, and hence the severity of disease.

journal_name

Bone Marrow Transplant

authors

Ihendyane N,Sparrelid E,Wretlind B,Remberger M,Andersson J,Ljungman P,Ringdén O,Normark BH,Allen U,Low DE,Norrby-Teglund A

doi

10.1038/sj.bmt.1704302

subject

Has Abstract

pub_date

2004-01-01 00:00:00

pages

79-85

issue

1

eissn

0268-3369

issn

1476-5365

pii

1704302

journal_volume

33

pub_type

杂志文章
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    authors: de Magalhaes-Silverman M,Simpson J,Ball E

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    journal_title:Bone marrow transplantation

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    doi:10.1038/sj.bmt.1704096

    authors: Muraro PA,Martin R

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  • Prophylaxis and treatment of chemo- and radiotherapy-induced oral mucositis - are there new strategies?

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    journal_title:Bone marrow transplantation

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    doi:10.1038/sj.bmt.1702024

    authors: Karthaus M,Rosenthal C,Ganser A

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  • Risk factors for acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation: retrospective analysis of 73 patients who received cyclosporin A.

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    journal_title:Bone marrow transplantation

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    doi:10.1038/sj.bmt.1705834

    authors: Izumi N,Furukawa T,Sato N,Okazuka K,Tsukada N,Abe T,Yano T,Kurasaki T,Masuko M,Toba K,Takahashi M,Aizawa Y

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  • Tandem high-dose chemotherapy supported by hematopoietic progenitor cells yields prolonged survival in stage IV breast cancer.

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    journal_title:Bone marrow transplantation

    pub_type: 临床试验,杂志文章

    doi:

    authors: Bitran JD,Samuels B,Klein L,Hanauer S,Johnson L,Martinec J,Harris E,Kempler J,White W

    更新日期:1996-02-01 00:00:00

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    journal_title:Bone marrow transplantation

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    doi:10.1038/sj.bmt.1701984

    authors: James R,May C,Diers M,Wagner J,McIvor R

    更新日期:1999-10-01 00:00:00

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    journal_title:Bone marrow transplantation

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    doi:10.1038/s41409-018-0145-1

    authors: Kordelas L,da Silva Nardi F,Wagner B,Ditschkowski M,Liebregts T,Lindemann M,Heinemann FM,Horn PA,Beelen DW,Rebmann V

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  • Valacyclovir prophylaxis for the prevention of Herpes simplex virus reactivation in recipients of progenitor cells transplantation.

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    journal_title:Bone marrow transplantation

    pub_type: 临床试验,杂志文章

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    authors: Dignani MC,Mykietiuk A,Michelet M,Intile D,Mammana L,Desmery P,Milone G,Pavlovsky S

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  • Similar incidence of graft-versus-host disease using HLA-A, -B and -DR identical unrelated bone marrow donors as with HLA-identical siblings.

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    journal_title:Bone marrow transplantation

    pub_type: 杂志文章

    doi:

    authors: Ringdén O,Remberger M,Persson U,Ljungman P,Aldener A,Andström E,Aschan J,Bolme P,Dahllöf G,Dalianis T

    更新日期:1995-04-01 00:00:00

  • Enumeration of CD34-positive hematopoietic progenitor cells by flow cytometry: comparison of a volumetric assay and the ISHAGE gating strategy.

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    journal_title:Bone marrow transplantation

    pub_type: 杂志文章

    doi:10.1038/sj.bmt.1701397

    authors: Leuner S,Arland M,Kahl C,Jentsch-Ullrich K,Franke A,Höffkes HG

    更新日期:1998-10-01 00:00:00

  • Relationship between TNFA, TNFB and TNFRII gene polymorphisms and outcome after unrelated hematopoietic cell transplantation in a Chinese population.

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    journal_title:Bone marrow transplantation

    pub_type: 杂志文章

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  • Pulmonary infection with microsporidia after allogeneic bone marrow transplantation.

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    journal_title:Bone marrow transplantation

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    doi:10.1038/sj.bmt.1704327

    authors: Teachey DT,Russo P,Orenstein JM,Didier ES,Bowers C,Bunin N

    更新日期:2004-02-01 00:00:00

  • Headache, circumoral paresthesia, and facial flushing associated with high-dose carmustine infusion.

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    journal_title:Bone marrow transplantation

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    doi:10.1038/sj.bmt.1700743

    authors: Woo MH,Ippoliti C,Bruton J,Mehra R,Champlin R,Przepiorka D

    更新日期:1997-04-01 00:00:00

  • Rapid helper T-cell recovery above 200 x 10 6/l at 3 months correlates to successful transplant outcomes after allogeneic stem cell transplantation.

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    journal_title:Bone marrow transplantation

    pub_type: 杂志文章

    doi:10.1038/sj.bmt.1705381

    authors: Kim DH,Sohn SK,Won DI,Lee NY,Suh JS,Lee KB

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  • Elevated lactate dehydrogenase is an adverse predictor of outcome in HLA-matched sibling bone marrow transplant for acute myelogenous leukemia.

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    journal_title:Bone marrow transplantation

    pub_type: 杂志文章

    doi:10.1038/sj.bmt.1705811

    authors: Kalaycio M,Rybicki L,Pohlman B,Dean R,Sweetenham J,Andresen S,Sobecks R,Sekeres MA,Advani A,Brown S,Bolwell B

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  • Engraftment syndrome: a common cause for rash and fever following autologous hematopoietic stem cell transplantation for multiple sclerosis.

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    journal_title:Bone marrow transplantation

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    journal_title:Bone marrow transplantation

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    doi:10.1038/sj.bmt.1700902

    authors: Hempel L,Körholz D,Nussbaum P,Bönig H,Burdach S,Zintl F

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  • Bone marrow transplantation in Hong Kong.

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    doi:

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  • Long-term oral complications of allogeneic haematopoietic SCT.

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    journal_title:Bone marrow transplantation

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    doi:10.1038/bmt.2011.63

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  • High frequency of antithrombin 3 and protein C deficiency following autologous bone marrow transplantation for lymphoma.

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    doi:

    authors: Gordon B,Haire W,Kessinger A,Duggan M,Armitage J

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  • Blood tacrolimus concentrations in bone marrow transplant patients undergoing plasmapheresis.

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    authors: Hale GA,Reece DE,Munn RK,Kniska AB,Phillips GL

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  • Circulating stem cell autografts.

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    journal_title:Bone marrow transplantation

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    doi:

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    journal_title:Bone marrow transplantation

    pub_type: 杂志文章

    doi:10.1038/bmt.2013.144

    authors: Bodet-Milin C,Lacombe M,Malard F,Lestang E,Cahu X,Chevallier P,Guillaume T,Delaunay J,Brissot E,Moreau P,Kraeber-Bodere F,Mohty M

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  • Adverse impact of high donor CD3+ cell dose on outcome following tandem auto-NMA allogeneic transplantation for high-risk myeloma.

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  • Cardiac complications in patients undergoing a reduced-intensity conditioning hematopoietic stem cell transplantation.

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    doi:

    authors: Christiansen NP,Haake RJ,Hurd DD

    更新日期:1991-06-01 00:00:00

  • Successful treatment of severe hepatic veno-occlusive disease after allogeneic bone marrow transplantation by transjugular intrahepatic portosystemic stent-shunt (TIPS).

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    doi:

    authors: Lévy V,Azoulay D,Rio B,Vincent F,Rabbat A,Hunault M,Bazarbachi A,Delmer A,Zittoun R

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  • Physical and psychosocial functioning of adult survivors of allogeneic bone marrow transplantation.

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    journal_title:Bone marrow transplantation

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    doi:

    authors: Andrykowski MA,Henslee PJ,Farrall MG

    更新日期:1989-01-01 00:00:00

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